| This database is a collection of 347 protein models of L. major proteome along with many aspects of protein structures for the purpose of drug discovery. LeishBase contains the homology models of annotated protein sequences of L. major built by using the templates from PDB having at least 40% identity. In addition to the structural information, general and biological information was collected for these proteins from various resources and links to relevant literature and databases have been provided. Comparison of host and parasite protein structures will provide insights for the identification of potential drug targets. A collection of organized data under a common relational platform will give significant leverage in drug discovery effort. |
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Prioritization of the targets:- |
| Availability of a target's structure significantly aids in rational drug design by providing strong practical advantage in high throughput docking and lead optimization studies. To identify and prioritize most potential drug targets a scoring scheme was designed based on the following parameters: |
| 1) Homology of the putative target with its human counterpart |
| 2) Presence of paralog of the putative target |
| 3) Involvement of the putative target in biochemical pathway |
| 4) Essentiality of the putative target in prokaryotes and eukaryotes |
| 5) Availability of homologue in Drug bank |
| Cite this work: Kaur S, Patel H, Sharma V, Garg P and Roy N. LeishBase: Leishmania major structural database. International Journal of Integrative Biology 2009, 7: 63-68. |
