| Possible adenylate kinase [Q9U1D3] | |
|---|---|
| Systematic Name | LmjF.04.0960 [Leishmania major] |
| Gene Name | L2256.03 |
| Molecular Weight | 23397 Da |
| Protein Sequence Size | 211 |
| Function | |
| Charge | -1 |
| Isoelectric Point | 6.1 pH |
| Description | Possible adenylate kinase. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q9U1D3|Q9U1D3_LEIMA Possible adenylate kinase - Leishmania major. SGETQQQQQQPQGTTPRKVFFILGGPGSGKGTNCARLVEDFGYTHFSAGELLREAARSGT GNLAKIGDIIRSGNIVPSEITVELLRQAIVDHPNSVGYVIDGFPRKEDQARMFEEGIAKP AGILYYDCSEATMEERLLSRGTNSTEKRDDDAAETIRHRFRVNVQECMPVVEAYKANGRC HVIDANRDRDTVYAETKKVFLEMGEKPLKA |
| DNA Sequence | >LmjF04.0960 |||adenylate kinase, putative|Leishmania major|chr 4|||Manual ATGTCGGGCG AGACTCAACA GCAGCAGCAG CAGCCGCAAG GTACGACACC GCGGAAGGTGTTCTTCATCC TTGGCGGGCC CGGCTCTGGC AAGGGCACGA ACTGCGCGCG GCTTGTGGAGGACTTTGGCT ACACCCATTT CAGCGCCGGC GAGCTGCTGC GCGAGGCGGC GCGCTCTGGCACGGGCAATC TGGCCAAGAT CGGCGATATC ATCCGCTCTG GAAACATTGT GCCGAGCGAGATCACGGTAG AGCTCCTTCG GCAGGCCATC GTCGATCACC CGAACTCCGT CGGCTACGTGATCGACGGCT TCCCGCGCAA GGAGGACCAG GCGCGCATGT TTGAGGAGGG CATCGCCAAGCCCGCCGGCA TCCTCTACTA CGACTGCAGC GAGGCCACCA TGGAGGAGCG CCTGCTCTCGCGCGGCACCA ACAGCACTGA GAAGCGCGAC GACGACGCTG CAGAGACGAT TCGGCATCGCTTCCGCGTCA ACGTGCAGGA GTGCATGCCG GTCGTGGAGG CCTACAAGGC GAATGGCCGCTGCCACGTCA TTGACGCGAA CCGCGACCGC GACACCGTCT ACGCCGAGAC GAAGAAAGTATTCCTCGAGA TGGGCGAGAA ACCTTTGAAG GCGTAG |
| Possible adenylate kinase Q9U1D3] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00945 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | adenylate kinase 1 [Homo sapiens] | 40 | 3e-34 | 142 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YKL024c uridine-monophosphate kinase | Saccharomyces cerevisiae | 44% | 3e-36 | 145 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00104 | Adenylate kinase signature | 99-110; | PS00113 | |
| Acylation | N-myristoylation site | 25-30; 28-33; 32-37; 142-147; | PS00008 | |
| Glycosylation | N-glycosylation site | 144-147; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 48-51; 133-136; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 16-18; 29-31; 146-148; 156-158; 197-199; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 37-44; 188-194; | PS00007 | |
| Possible adenylate kinase [Q9U1D3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 5ukdA | |
| Percent Identity | 41% | |
| Target Region | 14-205 | |
| Template Region | 2-192 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 18 | Sidechain |
| ARG | 128 | Sidechain |
| ARG | 136 | Sidechain |
| ASP | 138 | Sidechain |
| ASP | 139 | Sidechain |
| ARG | 147 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 58-64-0 | ADENOSINE-5'-DIPHOSPHATE | 427.201 | C10 H15 N5 O10 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 5ukd |
| 17949-86-9 | ALUMINUM FLUORIDE | 83.977 | Al F3 | F[Al](F)F | 5ukd |
| 84-52-6 | CYTIDINE-5'-MONOPHOSPHATE | 323.197 | C9 H14 N3 O8 P | O=C1N=C(N)C=CN1C2OC(C(O)C2O)COP(=O)(O)O | 5ukd |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 5ukd |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1507023/Q9U1D3.pdb 2.0 192 = residues | | = | +| Ramachandran plot: 95.2% core 3.6% allow 1.2% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 190) = | | Chi1-chi2 plots: 0 labelled residues (out of 111) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.5 Bad contacts: = 0 | *| Bond len/angle: 5.3 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.18 Covalent: -0.09 Overall: = 0.08 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | | M/c bond angles: 95.8% within limits 4.2% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |