| Adenylosuccinate lyase [Q9U0T7] | |
|---|---|
| Systematic Name | LmjF.04.0460 [Leishmania major] |
| Gene Name | P1421.03 |
| Molecular Weight | 53711 Da |
| Protein Sequence Size | 479 |
| Function | |
| Charge | -0.5 |
| Isoelectric Point | 6.4598 pH |
| Description | Adenylosuccinate lyase (EC 4.3.2.2). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 4.3.2.2 |
| Sequence | >tr|Q9U0T7|Q9U0T7_LEIMA Adenylosuccinate lyase (EC 4.3.2.2) - Leishmania major. SLPSAQEAAAPSVTTTAHKAPAEISQDNPLYSLSPLDGRYKRDTAALRAYFSEYALFKYR VQVEVLYFQALCKEVPVITQLRGVTDAQLEKLRATTFENFTVDDARMIKDIEAVTNHDIK AVEYYLKDKMSACGLEAEKEFIHFGLTSQDINNTSIPMLLRDALHHHYIPTLDQLIAHLK SKLPEWDVPMLARTHGQPASPTNLAKEFMVWIERLEEQRTMLLSIPNTGKFGGATGNFNA HLCAYPGVNWLEFGELFLSKYLGLRRQRYTTQIEHYDNLAAICDACARLHTILMDLAKDV WQYISLGYFDQKVKAGEVGSSAMPHKVNPIDFENAEGNLGMSNAVLGFLSAKLPISRLQR DLTDSTVLRNLGVPLSHALIAFASLQRGIGKLLLNKDVIAADLEGNWAVVAEGIQTVLRR EGYPKPYEALKDLTRGNAHVTEETVHRFIQQLEGITEEVRQELLAITPFTYVGYTARP |
| DNA Sequence | >LmjF04.0460 |||adenylosuccinate lyase, putative|Leishmania major|chr 4|||Manual ATGTCACTGC CTTCGGCACA AGAAGCGGCG GCGCCATCTG TGACCACGAC GGCACACAAGGCCCCTGCGG AGATCAGTCA AGACAACCCC CTCTACTCGC TCTCTCCTCT CGATGGTCGCTACAAGCGTG ACACGGCCGC GCTGCGCGCC TACTTCTCCG AATACGCGTT ATTCAAGTATCGCGTGCAGG TGGAGGTGCT GTACTTCCAA GCGCTGTGCA AGGAGGTGCC GGTGATCACGCAGCTTCGCG GCGTCACAGA TGCGCAGCTG GAGAAGCTGC GGGCAACCAC CTTCGAGAACTTCACAGTGG ACGATGCCCG GATGATAAAG GACATTGAGG CGGTCACGAA CCACGATATCAAGGCAGTGG AGTACTACCT GAAGGACAAG ATGTCTGCCT GCGGCCTCGA GGCCGAAAAGGAGTTCATCC ACTTTGGGCT AACGTCGCAG GACATCAACA ACACCTCGAT TCCGATGCTCCTGCGCGACG CTCTGCACCA CCACTACATC CCAACGCTGG ATCAGCTGAT CGCGCACCTCAAGAGCAAGC TGCCTGAGTG GGATGTCCCG ATGCTGGCCC GGACGCACGG CCAACCGGCGAGCCCGACGA ACTTGGCGAA GGAATTCATG GTGTGGATTG AGCGGCTGGA AGAGCAGCGGACGATGCTGC TGAGCATCCC AAACACAGGC AAGTTCGGCG GCGCTACCGG CAACTTCAACGCGCACCTCT GTGCGTACCC TGGCGTAAAC TGGCTGGAGT TTGGGGAGCT CTTCCTGAGCAAGTACCTTG GCCTTCGCCG CCAGCGCTAC ACAACTCAGA TCGAGCACTA CGACAACCTCGCCGCCATCT GCGATGCGTG CGCGCGGCTG CACACAATCT TGATGGACCT GGCCAAGGACGTGTGGCAGT ACATTTCACT CGGCTACTTT GATCAGAAGG TGAAGGCGGG CGAAGTCGGCAGCAGCGCGA TGCCGCATAA GGTGAACCCG ATCGACTTCG AGAACGCTGA GGGCAACCTGGGCATGAGCA ACGCCGTCCT CGGTTTTCTT TCAGCGAAGT TGCCCATCTC CCGTCTGCAGCGCGACCTCA CAGACAGCAC GGTGCTGCGC AACCTCGGCG TTCCGCTTAG CCACGCCCTCATCGCGTTTG CCTCCCTGCA ACGCGGCATC GGCAAGCTCC TTCTCAACAA GGACGTCATCGCCGCGGACC TAGAGGGCAA TTGGGCTGTC GTGGCGGAGG GCATCCAGAC CGTGCTGCGCCGGGAGGGCT ACCCGAAGCC GTACGAGGCG CTCAAGGACC TGACGCGCGG CAACGCGCATGTTACGGAGG AGACGGTGCA CCGCTTCATC CAGCAGCTCG AGGGCATCAC AGAGGAGGTGCGGCAGGAGC TGCTCGCCAT TACGCCCTTC ACGTACGTGG GCTACACGGC GCGTCCCTGA |
| Adenylosuccinate lyase Q9U0T7] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01756 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | adenylosuccinate lyase [Homo sapiens] | 26 | 0.000000002 | 61 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| purB adenylosuccinate lyase | Staphylococcus aureus | 23% | 2e-19 | 91.3 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 100-103; 153-156; 154-157; | PS00722 | |
| PDOC00147 | Fumarate lyases signature | 320-329; | PS00163 | |
| Acylation | N-myristoylation site | 84-89; 233-238; 234-239; 237-242; 341-346; 373-378; | PS00008 | |
| Glycosylation | N-glycosylation site | 100-103; 153-156; 154-157; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 42-45; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 5-8; 35-38; 96-99; 102-105; 116-119; 148-151; 272-275; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 229-231; 351-353; 476-478; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 61-68; | PS00007 | |
| Adenylosuccinate lyase [Q9U0T7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ptsA | |
| Percent Identity | 50% | |
| Target Region | 31-479 | |
| Template Region | 6-447 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| THR | 165 | Unknown |
| HIS | 166 | Unknown |
| LYS | 297 | Unknown |
| GLU | 304 | Unknown |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/4027430/Q9U0T7.pdb 2.0 449 = residues | | = | +| Ramachandran plot: 93.1% core 6.5% allow 0.5% gener 0.0% = disall | | = | +| All Ramachandrans: 10 labelled residues (out of 447) = | +| Chi1-chi2 plots: 2 labelled residues (out of 284) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 12.5 Bad contacts: = 4 | *| Bond len/angle: 10.4 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.14 Covalent: -0.17 Overall: = 0.03 | | = | | M/c bond lengths: 98.9% within limits 1.1% highlighted = | *| M/c bond angles: 94.0% within limits 6.0% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |