| D-3-phosphoglycerate dehydrogenase-like protein [Q9TXJ5] | |
|---|---|
| Systematic Name | LMJ_0162 [Leishmania major] |
| Gene Name | |
| Molecular Weight | 55548 Da |
| Protein Sequence Size | 511 |
| Function | |
| Charge | 9 |
| Isoelectric Point | 7.8451 pH |
| Description | D-3-phosphoglycerate dehydrogenase-like protein (EC 1.1.1.95). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 1.1.1.95 |
| Sequence | >tr|Q9TXJ5|Q9TXJ5_LEIMA D-3-phosphoglycerate dehydrogenase-like protein (EC 1.1.1.95) - Leishmania major. GIALCVIAVCAADKGLVDCRARGDVLFRNPVAIHSFASWRLLAQSIFELWVYKVSAPLSC CTRNYIDCISYLDNKEYFPSDLHFASALACRISFAGVHKKITTMPSLIDPPYHALLLEGV NPIAKELLESKGCIVEYIPNALPRDTLLEKIRDVHFLGIRSKTQVTQAILDAAPKLLGIG CFCIGTNQVDLDYATTRGVAVFNSPFANTRSVAELVIGEIISLSRKMTQRSEEVHRGVWN KTHVGCYEVRGKTVGIVGYGHIGSQVGVLAEALGMNVVFYDVLPTLAIGNATKFTHINDL LTFSDFVTIHVPETDVTKGMIGEEQIRLMKKGSYLINASRGTVVDLEALAKALREGHLAG AAIDVYPEEPGSNKELHRTPLQGISNVILTPHVGGSTCEAQEAIGVEVGTALAKFVTSGI TAGAVNFPELVRPPVDRSKFRLTNVHANVPGALNEINKVAVDLGCNMGMQFLSTSKAIGY LIMDVDKDVAVELRKRISALKYSIRTLIIR |
| DNA Sequence | |
| D-3-phosphoglycerate dehydrogenase-like protein Q9TXJ5] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00058 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | phosphoglycerate dehydrogenase [Homo sapiens] | 33 | 2e-45 | 180 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| serA D-3-phosphoglycerate dehydrogenase | Haemophilus influenzae | 48% | 1e-110 | 392 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 23-25; | PS00016 | |
| PDOC00063 | D-isomer specific 2-hydroxyacid dehydrogenases signatures | 255-282; | PS00065 | |
| PDOC00063 | D-isomer specific 2-hydroxyacid dehydrogenases signatures | 301-323; | PS00670 | |
| PDOC00063 | D-isomer specific 2-hydroxyacid dehydrogenases signatures | 330-346; | PS00671 | |
| Acylation | N-myristoylation site | 2-7; 16-21; 264-269; 395-400; 406-411; 410-415; 420-425; 465-470; | PS00008 | |
| Glycosylation | N-glycosylation site | 241-244; 291-294; 338-341; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 100-103; 226-229; 331-334; 496-499; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 46-49; 71-74; 107-110; 147-150; 212-215; 303-306; 343-346; 373-376; 397-400; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 39-41; 196-198; 225-227; 229-231; 373-375; 475-477; 504-506; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 64-72; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 71-85; ; 360-374; | PS00003 | |
| D-3-phosphoglycerate dehydrogenase-like protein [Q9TXJ5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1ybaD | |
| Percent Identity | 51% | |
| Target Region | 22-511 | |
| Template Region | 7-406 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLU | 349 | Sidechain |
| HIS | 372 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 2-OXYGLUTARIC ACID | 146.098 | C5 H6 O5 | O=C(O)C(=O)CCC(=O)O | 1yba | |
| NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 663.425 | C21 H27 N7 O14 P2 | c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N | 1yba | |
| 14265-44-2 | PHOSPHATE ION | 94.971 | O4 P | [O-]P([O-])([O-])=O | 1yba |
| UNKNOWN | 103.12 | C4 H9 N O2 | O=C(O)C(N)CC | 1yba | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/4894762/Q9TXJ5.pdb 2.0 490 = residues | | = | +| Ramachandran plot: 90.7% core 8.4% allow 0.9% gener 0.0% = disall | | = | *| All Ramachandrans: 17 labelled residues (out of 488) = | +| Chi1-chi2 plots: 8 labelled residues (out of 273) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 6.1 Bad contacts: = 10 | *| Bond len/angle: 8.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.02 Covalent: -0.25 Overall: = -0.10 | | = | | M/c bond lengths: 98.6% within limits 1.4% highlighted = | *| M/c bond angles: 93.1% within limits 6.9% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |