| LmRab7 GTP-binding protein [Q9N2P5] | |
|---|---|
| Systematic Name | LmjF.18.0890 [Leishmania major] |
| Gene Name | LMRAB7 |
| Molecular Weight | 24149 Da |
| Protein Sequence Size | 223 |
| Function | |
| Charge | -3.5 |
| Isoelectric Point | 5.0779 pH |
| Description | LmRab7 GTP-binding protein (Rab7 GTP binding protein, putative). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q9N2P5|Q9N2P5_LEIMA LmRab7 GTP-binding protein (Rab7 GTP binding protein, putative) - Leishmania major. SMKRQLLKIIILGDSGVGKTSLMHQYVNRIFDNRYKATIGADFLSKDVEVNGCVVTLQIW DTAGQERFQSLGSAFYRGADACILVFDVTQQESFAHVGSWLEEFSIQAGRRDSVLVGNKT DLEDRRQVASKTVQAWCAKQNAEAANAINGACAGAGDSAAPEMKYFETSAKDNAGVEEAF IAVVQLALARKATVEEATPMPQTVNLSQAQHEQTPTSSACSC |
| DNA Sequence | >LmjF18.0890 |RAB7||rab7 GTP binding protein, putative|Leishmania major|chr 18|||Manual ATGTCGATGA AGCGGCAGTT GCTGAAGATC ATCATCCTGG GTGACAGCGG TGTCGGCAAGACGTCGCTCA TGCATCAGTA CGTGAACCGC ATATTTGACA ACCGCTACAA GGCAACTATCGGCGCTGACT TCCTTTCGAA GGACGTGGAG GTGAACGGGT GCGTGGTGAC GCTGCAGATCTGGGACACGG CCGGGCAGGA GCGGTTCCAG TCGCTCGGCT CCGCCTTCTA CCGTGGTGCAGACGCTTGCA TCCTTGTCTT TGATGTGACG CAGCAGGAGT CTTTTGCGCA CGTTGGCTCGTGGCTGGAGG AGTTCAGCAT CCAGGCGGGC CGCCGTGACA GCGTGTTGGT GGGCAACAAGACGGACCTGG AGGATCGGCG CCAGGTGGCC AGTAAGACAG TGCAAGCGTG GTGCGCGAAGCAGAACGCGG AGGCCGCTAA TGCGATCAAC GGCGCATGTG CCGGAGCGGG TGATAGTGCGGCGCCAGAGA TGAAGTACTT TGAGACGTCC GCAAAGGATA ACGCCGGCGT CGAGGAAGCCTTCATTGCTG TGGTACAGCT GGCGCTGGCC AGGAAGGCAA CGGTTGAGGA GGCGACACCGATGCCGCAGA CGGTGAACCT GAGTCAAGCC CAGCACGAGC AGACACCCAC CTCCTCCGCCTGCAGCTGCT AA |
| LmRab7 GTP-binding protein Q9N2P5] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding; GTPase activity |
| Biochemical Pathway | intracellular protein transport; protein transport; small GTPase mediated signal transduction |
| Regulatory Pathway | |
| KEGG Pathways | K07897 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | RAB7, member RAS oncogene family [Homo sapiens] | 50 | 7e-54 | 207 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL038c GTP-binding protein of the rab family | Saccharomyces cerevisiae | 39% | 5e-31 | 128 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 14-21; | PS00017 | |
| PDOC00579 | Sigma-54 interaction domain signatures and profile | 10-23; | PS00675 | |
| Acylation | N-myristoylation site | 17-22; 53-58; 79-84; 151-156; 155-160; 176-181; | PS00008 | |
| Amidation | Amidation site | 109-112; | PS00009 | |
| Glycosylation | N-glycosylation site | 119-122; 206-209; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 111-114; 191-194; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 90-93; 100-103; 121-124; 170-173; 194-197; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 2-4; 170-172; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 30-36; | PS00007 | |
| LmRab7 GTP-binding protein [Q9N2P5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1vg8D | |
| Percent Identity | 50% | |
| Target Region | 6-205 | |
| Template Region | 1-184 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLN | 61 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 522.196 | C10 H17 N6 O13 P3 | O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 1vg8 | |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1vg8 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2265770/Q9N2P5.pdb 2.0 200 = residues | | = | | Ramachandran plot: 94.4% core 5.6% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 198) = | | Chi1-chi2 plots: 0 labelled residues (out of 109) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 6.5 Bad contacts: = 2 | *| Bond len/angle: 7.0 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.06 Covalent: -0.17 Overall: = -0.03 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 92.2% within limits 7.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |