| Putative aurora/Ipl1p-like protein kinase [Q9N2N1] | |
|---|---|
| Systematic Name | LmjF.28.0520 [Leishmania major] |
| Gene Name | LMAIRK |
| Molecular Weight | 34819 Da |
| Protein Sequence Size | 301 |
| Function | |
| Charge | 9.5 |
| Isoelectric Point | 8.2 pH |
| Description | Putative aurora/Ipl1p-like protein kinase (EC 2.7.1.37) (Protein kinase, putative). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.1.37 |
| Sequence | >tr|Q9N2N1|Q9N2N1_LEIMA Putative aurora/Ipl1p-like protein kinase (EC 2.7.1.37) (Protein kinase, putative) - Leishmania major. TTEVGPDDNVVNNFIITPSSPKSEWTIHDFELLHKLGGGNYGDVYLASVRKSNYVVAIKK LSIKKLAEFDIVNQLRREIEIAFNTRHKYLLRTYAYFFDEHDIYLILEPCSNGMLYSELN RVKLFPPPTAARYVAQLAEALLYLHQHHILHRDIKPENILLDHHQNIKLADFGWSVHDPL NRRKTSCGTPEYFPPEIVSRQMYDMSADLWCLGIFCFELLVGHTPFVSKDNDQIYKKIHA MQYTIPDSVPPEAKDLISNLLIREGSKRLALHRVLSHPFLLKYYYVPNGITPPTGKRPRS |
| DNA Sequence | >LmjF28.0520 |LMAIRK||protein kinase, putative|Leishmania major|chr 28|||Manual ATGACGACAG AGGTCGGCCC GGACGACAAT GTCGTGAACA ACTTCATCAT TACCCCGTCGTCCCCAAAGT CGGAGTGGAC GATACACGAC TTTGAGCTGC TGCACAAGCT GGGAGGAGGCAATTACGGTG ATGTCTACCT GGCGAGTGTC CGCAAGAGCA ACTACGTCGT GGCCATCAAGAAGCTCTCGA TCAAGAAGCT GGCAGAGTTT GACATTGTGA ACCAGCTGCG GCGCGAGATCGAGATCGCCT TCAACACGCG ACACAAATAC CTCCTACGCA CCTACGCCTA CTTCTTCGATGAGCACGACA TCTACCTTAT CCTGGAGCCG TGCAGCAACG GCATGCTCTA CAGCGAGCTGAATCGCGTGA AGCTGTTCCC GCCGCCGACG GCAGCCCGCT ATGTGGCGCA GCTCGCCGAGGCACTTCTTT ACCTCCACCA GCACCACATT CTGCACCGCG ACATCAAGCC GGAGAACATTCTGCTGGATC ATCATCAGAA CATCAAACTC GCCGATTTCG GCTGGTCTGT GCATGACCCGCTGAACCGGC GCAAGACCTC CTGCGGCACG CCCGAGTACT TCCCCCCCGA GATCGTTAGCCGGCAGATGT ATGACATGAG CGCCGATCTC TGGTGCCTGG GCATCTTCTG CTTTGAACTGCTTGTGGGCC ACACACCGTT CGTGAGCAAG GACAACGACC AAATCTACAA GAAGATCCATGCGATGCAGT ACACCATCCC CGACAGCGTC CCACCAGAGG CGAAGGATTT GATTTCAAATCTGCTCATCC GCGAGGGGTC GAAGCGGCTG GCGCTACATC GCGTGCTGAG CCACCCCTTCTTGCTCAAAT ACTACTATGT TCCAAACGGC ATTACGCCGC CGACGGGAAA GCGGCCGCGCAGCTAG |
| Putative aurora/Ipl1p-like protein kinase Q9N2N1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity |
| Biochemical Pathway | protein amino acid phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K08850 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | aurora kinase B [Homo sapiens] | 45 | 1e-65 | 246 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPL209c serthr protein kinase | Saccharomyces cerevisiae | 41% | 4e-56 | 212 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00100 | Protein kinases signatures and profile | 37-66; | PS00107 | |
| PDOC00100 | Protein kinases signatures and profile | 150-162; | PS00108 | |
| PDOC00100 | Protein kinases signatures and profile | 46.039 | 31-281 | PS50011 |
| Acylation | N-myristoylation site | 39-44; 114-119; | PS00008 | |
| Amidation | Amidation site | 295-298; | PS00009 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 60-63; 183-186; 184-187; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 27-30; 176-179; 245-248; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 21-23; 49-51; 63-65; 267-269; 295-297; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 230-236; | PS00007 | |
| Putative aurora/Ipl1p-like protein kinase [Q9N2N1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2j4zB | |
| Percent Identity | 44% | |
| Target Region | 24-290 | |
| Template Region | 126-267 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 131 | Sidechain |
| LYS | 133 | Sidechain |
| ASN | 136 | Sidechain |
| THR | 167 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)- 1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE | 448.541 | C23 H24 N6 O2 S | O=C(n4cc3nnc(NC(=O)c2ccc(N1CCN(C)CC1)cc2)c3c4)Cc5sccc5 | 2j4z | |
| 7440-38-2 | ARSENIC | 74.922 | As | [AsH3] | 2j4z |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1090932/Q9N2N1.pdb 2.0 267 = residues | | = | +| Ramachandran plot: 90.8% core 8.3% allow 0.8% gener 0.0% = disall | | = | +| All Ramachandrans: 7 labelled residues (out of 265) = | +| Chi1-chi2 plots: 3 labelled residues (out of 185) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.6 Bad contacts: = 2 | *| Bond len/angle: 7.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.06 Covalent: -0.11 Overall: = 0.00 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 93.8% within limits 6.2% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |