| Cation-transporting ATPase [Q95Z93] | |
|---|---|
| Systematic Name | LmjF.04.0010 [Leishmania major] |
| Gene Name | LT.01 |
| Molecular Weight | 111720 Da |
| Protein Sequence Size | 1023 |
| Function | |
| Charge | -8 |
| Isoelectric Point | 5.7 pH |
| Description | Cation-transporting ATPase. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q95Z93|Q95Z93_LEIMA Cation-transporting ATPase - Leishmania major. AKLVLPDDPASMDGHLICSLLEVKEARGLAQDEVDKRLHEFGKNELSTGPSTPFWKLVVG QFEDTLVRILLLAAFVSFCLAVLESNMMDLVEPFIILLILTLNAIVGVWQEDRAEKAIDA LKDFVPETAVVVREGMTQRILAENLVPGDIVEIAVGDRVAADVRLLTLESTTLRVDQSIL NGESVEAMKQVESVRVKRERFPSSMVYRGTAVVYGKARGVVVRTGKSTEMGFIERDVREQ EETKTPLQLKLDEFGVLLSTVIGFICLFVFVVNLLHWFRTHPAATEESWFERYIEPTVHS LKVAVALAVAAIPEGLPAVVTTCLALGSRKMARQNALVRDLPSVETLGRCTVICSDKTGT LTTNMMSVSEVVTMEVSGKAHKYSIHDSRFNVVAAAVSHNGTPAGEALGNDAALDMVATI ATLCSDASLVCGTRSAEVEKVGDATEAALLVMSEKLYHSAARNGVDGAHLPVDRCRSLKR QLWLKKATLEFTRSRKSMSVCCTSTEDARIHSLFVKGAPEEILKRCTRIMFKDGHISPLT PKMVNTVTANIDRMSGAEEALRCIAFAFRPLPDPKQLDLSDPAKFEAIESDLTFIGVCGM LDPPRREVADAIAKCRTAGIRVIVITGDKKETAEAVCRRIGLMPYEPTTGLSFTGYELDQ MTPAQRRAAVSSAVLFSRTDPSHKMQLVNLLQEQKLICAMTGDGVNDSPALKKADIGIAM GSGTEVAKAASKMVLADDNFATVVKAVREGRTIFNNTKQFIRYLISSNIGEVACVLATGL FGLPEALSPIQLLWVNLVTDGLPATALGFNAADPDIMEQAPRRGDEPIVDGWLFFRYMIV GIYVGLATVAGFVWWFLTNGFTLADLASFTTCTDMSNSKCAELANPQTARAIALSILVVV EMLNALNALSENQSLVVIRPSTNKWLIAAICSSIALHLTIMYIPFFSRLFGVTSLGVDAD VVATANPWDVLLPTDFTDWRTVLVLSIPVIFLDELLKLFSRCSNHHRENYSAEWVVGGMS RM |
| DNA Sequence | >LmjF04.0010 |||calcium-translocating P-type ATPase|Leishmania major|chr 4|||Manual ATGGCTAAAC TAGTGCTGCC GGACGATCCG GCCTCGATGG ACGGTCACCT AATTTGCTCATTGCTAGAGG TGAAAGAGGC CCGTGGTCTT GCTCAGGATG AAGTCGACAA GCGCCTTCATGAATTTGGCA AAAATGAGCT TTCCACAGGG CCCTCAACGC CCTTCTGGAA GCTAGTTGTTGGTCAATTCG AGGACACGCT TGTGCGCATT TTGCTCCTGG CGGCGTTTGT AAGTTTCTGTTTGGCAGTTC TAGAAAGCAA CATGATGGAC CTCGTGGAGC CGTTTATTAT TTTGCTGATTTTGACGCTGA ATGCTATTGT TGGTGTTTGG CAAGAAGACC GAGCGGAAAA AGCAATTGACGCCTTGAAAG ACTTTGTTCC TGAAACAGCT GTTGTTGTTC GTGAGGGCAT GACGCAGAGGATCCTGGCAG AAAACCTTGT TCCTGGAGAT ATTGTCGAGA TCGCTGTAGG AGATCGCGTCGCTGCCGATG TTCGGCTGCT AACGCTGGAA AGCACGACGC TGCGCGTTGA TCAGTCGATTCTGAACGGCG AGTCGGTGGA AGCCATGAAG CAGGTGGAGT CGGTTCGCGT CAAGCGGGAGCGGTTTCCTT CGAGCATGGT TTACCGCGGT ACTGCCGTTG TGTATGGCAA GGCTCGTGGCGTCGTCGTGC GCACTGGAAA GTCCACCGAG ATGGGCTTTA TCGAGCGTGA CGTGCGTGAGCAGGAGGAAA CGAAAACGCC GCTGCAGCTG AAGCTGGACG AGTTCGGCGT TCTCCTGTCAACGGTAATTG GTTTTATTTG TCTTTTCGTG TTCGTGGTGA ATCTCCTTCA CTGGTTCAGAACCCACCCGG CGGCTACTGA GGAGTCCTGG TTTGAACGGT ATATCGAGCC CACCGTTCATTCGCTGAAGG TGGCTGTGGC TTTAGCTGTC GCTGCTATCC CTGAGGGCCT ACCAGCAGTGGTCACAACGT GTCTGGCGCT CGGTTCACGC AAGATGGCGC GACAGAACGC TCTTGTGCGCGATCTACCGA GCGTGGAAAC GCTTGGTCGA TGCACCGTAA TCTGCTCCGA CAAGACGGGAACGCTAACGA CGAACATGAT GTCCGTGTCG GAAGTGGTGA CAATGGAAGT GTCCGGTAAAGCCCATAAGT ACAGCATACA TGACTCGAGG TTCAACGTCG TGGCGGCAGC CGTTTCGCACAACGGCACTC CAGCCGGTGA GGCGCTCGGC AACGACGCCG CGCTGGACAT GGTGGCCACGATTGCCACGT TGTGCAGCGA TGCATCGCTA GTCTGCGGCA CGCGCTCGGC GGAGGTGGAAAAGGTAGGGG ACGCCACCGA GGCGGCTCTT CTGGTGATGA GTGAAAAGCT GTACCACAGTGCGGCACGGA ATGGGGTGGA CGGTGCGCAT TTGCCGGTTG ACCGATGCAG ATCATTGAAAAGGCAGCTTT GGCTCAAGAA GGCGACGCTG GAGTTTACGC GCTCTCGCAA ATCGATGAGTGTGTGTTGCA CGTCGACCGA GGACGCACGC ATTCACAGCC TCTTTGTGAA AGGGGCGCCGGAAGAGATTC TCAAGCGTTG CACTCGTATC ATGTTTAAGG ATGGTCACAT TTCTCCTCTCACACCGAAAA TGGTGAATAC CGTGACGGCG AACATCGATC GTATGTCCGG CGCAGAGGAGGCCCTCCGCT GTATCGCTTT TGCCTTTCGC CCCCTTCCCG ACCCGAAGCA ACTGGATCTGTCCGATCCAG CCAAGTTTGA AGCCATCGAG AGCGACCTCA CGTTTATCGG TGTCTGCGGCATGCTGGACC CTCCGCGGAG GGAGGTGGCA GATGCGATCG CCAAGTGTCG AACAGCGGGGATTCGCGTCA TCGTCATCAC CGGCGACAAG AAGGAGACAG CAGAGGCAGT GTGCCGCCGAATCGGACTCA TGCCATATGA GCCGACAACG GGGTTGAGCT TCACCGGCTA TGAGCTGGATCAGATGACCC CAGCACAAAG GCGGGCGGCG GTGAGCAGTG CTGTGCTTTT CAGTCGCACCGACCCCTCCC ATAAGATGCA GTTGGTGAAT CTTCTGCAGG AGCAGAAGCT CATTTGCGCCATGACCGGCG ACGGCGTGAA CGACTCGCCG GCGCTGAAGA AGGCCGATAT CGGGATTGCCATGGGCTCCG GGACAGAGGT GGCGAAGGCG GCGAGCAAGA TGGTGCTGGC AGATGACAATTTCGCCACGG TCGTGAAGGC TGTGCGTGAG GGTCGTACCA TTTTCAACAA CACAAAGCAGTTCATCCGCT ACCTCATTAG CAGCAACATT GGCGAGGTAG CCTGCGTTCT GGCTACGGGACTGTTTGGCC TACCAGAAGC ACTCTCGCCG ATTCAGCTCT TGTGGGTGAA TCTCGTTACGGACGGGCTGC CGGCAACCGC GCTGGGGTTC AACGCTGCCG ACCCAGACAT CATGGAACAGGCACCGCGGC GAGGAGACGA GCCCATTGTT GACGGATGGC TTTTCTTTCG CTACATGATTGTCGGCATTT ATGTTGGTCT GGCTACGGTC GCGGGGTTTG TCTGGTGGTT TCTGACGAACGGATTCACCT TGGCCGACCT CGCCTCATTC ACCACGTGCA CGGACATGAG CAATTCCAAGTGTGCAGAGC TGGCGAACCC GCAGACGGCG CGCGCCATCG CGTTGTCCAT CCTGGTTGTCGTCGAGATGC TGAATGCGCT GAACGCGCTT AGCGAGAATC AGTCGCTTGT CGTGATCCGGCCTTCGACAA ACAAGTGGCT CATTGCGGCC ATTTGCTCTT CGATCGCGCT GCACCTCACGATCATGTACA TTCCGTTCTT TTCGCGCCTG TTCGGCGTCA CCTCACTCGG CGTGGATGCTGATGTCGTGG CGACCGCGAA CCCGTGGGAC GTGTTGCTGC CTACTGATTT CACGGACTGGAGAACAGTAC TTGTGCTGAG CATCCCGGTT ATTTTCCTCG ACGAGCTGTT AAAGCTTTTTTCGAGGTGCA GCAATCACCA CCGTGAAAAC TATAGCGCAG AGTGGGTTGT TGGTGGGATGAGCCGTATGT AG |
| Cation-transporting ATPase Q95Z93] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01537 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ATPase, Ca++ transporting, fast twitch 1 isoform a [Homo sapiens] | 47 | 0 | 813 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| pacL P-type ATPase - calcium transporter | Streptococcus pneumoniae | 33% | 1e-128 | 453 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 824-826; | PS00016 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 756-759; 913-916; 1010-1013; | PS00722 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 1021-1023; | PS00342 | |
| Acylation | N-myristoylation site | 256-261; 360-365; 402-407; 410-415; 433-438; 465-470; 557-562; 651-656; 718-723; 724-729; 783-788; 802-807; 842-847; | PS00008 | |
| E1-E2 ATPases phosphorylation site | P-type ATPases phosphorylation site | 357-363; | PS00154 | |
| Glycosylation | N-glycosylation site | 756-759; 913-916; 1010-1013; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 486-489; 525-528; 630-633; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 20-23; 289-292; 368-371; 385-388; 504-507; 505-508; 556-559; 655-658; 678-681; 723-726; 863-866; 872-875; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 138-140; 173-175; 194-196; 225-227; 301-303; 329-331; 356-358; 378-380; 454-456; 478-480; 495-497; 541-543; 683-685; 889-891; 923-925; | PS00005 | |
| Cation-transporting ATPase [Q95Z93] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2zbgA | |
| Percent Identity | 47% | |
| Target Region | 1-1042 | |
| Template Region | 1-994 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 357 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| ACETYL GROUP | 44.053 | C2 H4 O | O=CC | 2zbg | |
| 21340-02-3 | TETRAFLUOROALUMINATE ION | 102.975 | Al F4 | F[Al-](F)(F)F | 2zbg |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2zbg |
| THAPSINGARGIN | 650.754 | C34 H50 O12 | O=C3OC2C1=C(C(OC(=O)\C(=C/C)C)C(OC(=O)CCCCCCC)C1C(OC(=O)C)(CC(OC(=O)CCC)C2(O)C3(O)C)C)C | 2zbg | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/598545/Q95Z93.pdb 2.0 1023 = residues | | = | *| Ramachandran plot: 91.6% core 7.3% allow 0.8% gener 0.3% = disall | | = | *| All Ramachandrans: 31 labelled residues (out of1021) = | +| Chi1-chi2 plots: 5 labelled residues (out of 555) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.6 Bad contacts: = 12 | *| Bond len/angle: 7.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.09 Covalent: -0.13 Overall: = 0.01 | | = | | M/c bond lengths: 99.1% within limits 0.9% highlighted = | | M/c bond angles: 94.5% within limits 5.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |