| Proteasome subunit beta type [Q8I6Y3] | |
|---|---|
| Systematic Name | LmjF.34.4340 [Leishmania major] |
| Gene Name | |
| Molecular Weight | 24694 Da |
| Protein Sequence Size | 220 |
| Function | |
| Charge | -5 |
| Isoelectric Point | 4.8 pH |
| Description | Proteasome subunit beta type. |
| Subcellular Location | proteasome core complex (sensu Eukaryota); proteasome core complex, beta-subunit complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q8I6Y3|Q8I6Y3_LEIMA Proteasome subunit beta type - Leishmania major. ASGASVIAIKYNGGVLMAADTLLSYGSLAKWPNIPRIKLLGSHSAVCATGSYADFQMMAK QVEDNIERQRMYYNVDELNPSEVFSYLHRSIYQKRCDFEPCLCQMVFIGVRDSETFLAAV DDVGTRWEDDCVATGYGAYIALPLLRQALEKNPGGLSRAQAVQILTDCLRVLFYRECRTI NKFQMADAAGDGVRISEPFDVETNWEYEGFCFEKTAIIR |
| DNA Sequence | >LmjF34.4340 |||20s proteasome beta 7 subunit, putative|Leishmania major|chr 34|||Manual ATGGCGTCTG GCGCATCTGT CATCGCGATC AAGTACAACG GCGGCGTACT GATGGCGGCGGACACGCTGC TGTCCTACGG GTCTCTCGCC AAGTGGCCCA ACATCCCGCG CATCAAGCTGCTCGGCAGCC ACTCCGCCGT GTGCGCCACG GGCAGCTACG CCGACTTCCA GATGATGGCGAAGCAGGTGG AGGACAACAT TGAGCGGCAG AGGATGTACT ACAACGTGGA CGAGTTGAACCCCAGTGAGG TGTTCAGCTA CCTGCACCGC TCCATCTACC AGAAGCGCTG CGACTTCGAGCCGTGCCTGT GTCAGATGGT CTTCATTGGC GTGCGCGACA GCGAGACGTT TCTGGCGGCCGTGGACGACG TCGGCACGCG CTGGGAGGAC GACTGCGTCG CGACCGGCTA CGGCGCGTACATCGCACTGC CGCTGCTGCG CCAGGCGCTG GAGAAGAATC CGGGCGGCCT GTCGCGGGCCCAGGCGGTGC AGATCCTCAC CGACTGCCTG CGTGTGCTCT TCTACCGCGA GTGCCGCACCATCAACAAGT TTCAGATGGC CGACGCCGCC GGCGACGGTG TGCGCATCAG CGAGCCCTTCGACGTGGAGA CGAACTGGGA GTACGAGGGC TTCTGCTTCG AGAAGACGGC CATCATCCGCTGA |
| Proteasome subunit beta type Q8I6Y3] | |
|---|---|
| Metabolite Information | ubiquitin-dependent protein catabolism |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K02736 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome beta 4 subunit [Homo sapiens] | 41 | 5e-41 | 164 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFR050c 20S proteasome subunit(beta7) | Saccharomyces cerevisiae | 31% | 1e-23 | 103 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00668 | Proteasome B-type subunits signature | 8-55; | PS00854 | |
| Acylation | N-myristoylation site | 15-20; 42-47; 110-115; 138-143; 156-161; 193-198; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 52-55; 126-129; 204-207; | PS00006 | |
| Proteasome subunit beta type [Q8I6Y3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruN | |
| Percent Identity | 41% | |
| Target Region | 1-218 | |
| Template Region | 1-217 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2388493/Q8I6Y3.pdb 2.0 214 = residues | | = | | Ramachandran plot: 91.6% core 8.4% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 212) = | | Chi1-chi2 plots: 0 labelled residues (out of 127) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.5 Bad contacts: = 4 | +| Bond len/angle: 3.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.04 Covalent: -0.18 Overall: = -0.04 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 92.2% within limits 7.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |