| Ret2, rna editing complex mp57 [Q6T450] | |
|---|---|
| Systematic Name | LmjF.26.0390 [Leishmania major] |
| Gene Name | |
| Molecular Weight | 57645 Da |
| Protein Sequence Size | 510 |
| Function | |
| Charge | 16.5 |
| Isoelectric Point | 8.6394 pH |
| Description | Ret2, rna editing complex mp57 (RNA editing 3' terminal uridylyl transferase 2). |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q6T450|Q6T450_LEIMA Ret2, rna editing complex mp57 (RNA editing 3' terminal uridylyl transferase 2) - Leishmania major. HAPTPLYLYVAVTRGLCSSAVAASSSADAASSPSAASSSTSEGVSYASHLVASNDHYVQW GRALLEENSKRIGPEQMFRTAIRAQQQLQMLADKWTPDAKIYCCGSLVTHGQMEWGSDLD LACVFDDPYPDHSVQAKRTEKLWSVVKRYMPQFLRNNLLALTEARTPVVKLRYVNDDKVA RGRYTVLTEEEDRKSRTTLWDIRNRHLDSKDLEYIATKMGRENIEGIWVERTTYGCRCAV QCTSREQAVGAVGFFPDGVIMTKGMREDYTRDMLDLRYVPEMFMYKWDISFVAYGVKNSY LLRHYLHNGPPAARHAAMAAKAWGKASGVGLGTAAMLTSYAVTVMFVHYLLATRQLAWID PWSLAHPVHMPRFPDFSPLLDCDPAELGKLLHGFFIYYASHFNYEKNIISLSRPRLSLRS DVNWNFPQSKQGTFSYLLGIEDPYEDVGVGGLNLGRHLHPAKFNQVKQEFARAATTMERY VPSNAPEKTILGVRRGGTSNHHHHHNRFD |
| DNA Sequence | >LmjF26.0390 |RET2||RNA editing 3' terminal uridylyl transferase 2|Leishmania major|chr 26|||Manual ATGCACGCTC CTACGCCACT GTACCTCTAC GTGGCCGTCA CGCGCGGGTT GTGTTCCAGCGCGGTGGCGG CGTCGAGCTC GGCTGACGCT GCATCTTCGC CGAGCGCGGC GTCCTCGTCGACGTCCGAGG GGGTCAGCTA TGCCTCGCAC CTCGTTGCTT CGAACGATCA CTACGTACAGTGGGGTCGTG CACTGCTGGA GGAGAACAGC AAGCGGATCG GTCCAGAGCA GATGTTTCGTACGGCCATTC GGGCCCAACA GCAGCTGCAG ATGCTTGCCG ACAAGTGGAC ACCGGATGCGAAAATTTACT GCTGCGGGTC GTTGGTAACG CACGGGCAGA TGGAGTGGGG CAGCGACCTCGACCTTGCCT GTGTCTTCGA CGACCCGTAC CCCGACCACT CCGTGCAGGC GAAGCGCACGGAAAAGCTGT GGTCAGTTGT CAAGCGCTAC ATGCCGCAGT TTCTGCGCAA CAATCTCTTGGCCCTCACGG AGGCTCGCAC CCCTGTCGTG AAACTGCGCT ACGTCAACGA CGACAAGGTCGCGCGGGGGC GGTACACCGT GCTGACGGAG GAGGAGGACC GCAAGTCGCG CACGACCCTGTGGGACATAC GCAACCGCCA TCTGGATTCC AAGGACCTGG AGTACATCGC CACAAAGATGGGGCGAGAGA ATATCGAGGG CATCTGGGTG GAGCGGACGA CGTATGGCTG CCGGTGCGCGGTGCAGTGCA CGTCGCGCGA GCAAGCCGTC GGGGCTGTCG GCTTCTTCCC AGATGGGGTGATCATGACCA AGGGCATGCG CGAGGACTAC ACGCGCGACA TGCTGGACCT CCGATACGTGCCGGAGATGT TTATGTACAA GTGGGATATT TCTTTTGTGG CTTACGGCGT CAAGAACAGCTACCTGCTCC GCCACTATCT GCACAACGGC CCCCCAGCTG CCCGCCACGC AGCCATGGCCGCGAAGGCGT GGGGCAAGGC CTCCGGCGTG GGGCTGGGGA CGGCAGCCAT GCTCACCTCCTACGCGGTGA CGGTCATGTT TGTTCACTAC CTCTTGGCAA CTCGGCAGCT GGCCTGGATCGACCCGTGGT CGTTAGCCCA TCCAGTCCAC ATGCCGCGCT TCCCCGACTT CTCCCCACTTTTGGACTGCG ACCCGGCCGA GCTCGGCAAG CTCCTGCACG GCTTCTTCAT CTACTACGCGTCTCACTTCA ACTATGAGAA GAACATTATC AGCCTCAGCC GCCCACGGCT TTCACTCCGCTCCGACGTGA ACTGGAACTT CCCGCAGAGC AAGCAGGGCA CATTCAGCTA CCTCCTCGGCATCGAGGACC CGTACGAAGA CGTCGGGGTT GGCGGACTGA ACCTCGGTCG CCACCTGCATCCAGCTAAGT TCAACCAGGT GAAGCAGGAA TTCGCGCGTG CGGCCACCAC GATGGAGCGCTACGTGCCGT CGAATGCGCC CGAAAAGACA ATCCTCGGTG TCAGACGCGG GGGTACGTCGAACCACCATC ATCACCATAA CCGCTTCGAT TAG |
| Ret2, rna editing complex mp57 Q6T450] | |
|---|---|
| Metabolite Information | |
| Molecular Function | RNA uridylyltransferase activity; nucleic acid binding |
| Biochemical Pathway | RNA editing |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | PAP associated domain containing 4 [Homo sapiens] | 24 | 0.00001 | 49 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YLR066w signal peptidase subunit | Saccharomyces cerevisiae | 27% | 0.56 | 30 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 16-21; 44-49; 106-111; 236-241; 259-264; 296-301; 329-334; 331-336; 452-457; 493-498; 497-502; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 26-29; 40-43; 118-121; 189-192; 199-202; 244-247; 476-479; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 70-72; 140-142; 244-246; 418-420; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 95-103; 272-279; 278-286; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 123-137; 438-452; | PS00003 | |
| Ret2, rna editing complex mp57 [Q6T450] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2b56A | |
| Percent Identity | 67% | |
| Target Region | 52-494 | |
| Template Region | 30-443 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 271 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2b56 |
| 58-97-9 | URIDINE-5'-MONOPHOSPHATE | 324.181 | C9 H13 N2 O9 P | O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O)O | 2b56 |
| 58-98-0 | URIDINE 5'-TRIPHOSPHATE | 484.141 | C9 H15 N2 O15 P3 | O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O | 2b56 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2087631/Q6T450.pdb 2.0 443 = residues | | = | | Ramachandran plot: 93.9% core 6.1% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 441) = | +| Chi1-chi2 plots: 4 labelled residues (out of 271) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 5.7 Bad contacts: = 2 | *| Bond len/angle: 7.0 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.14 Covalent: -0.11 Overall: = 0.05 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 94.6% within limits 5.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |