| ADP-ribosylation factor 1 [Q6IMM3] | |
|---|---|
| Systematic Name | LmjF.31.2280 [Leishmania major] |
| Gene Name | ARF1 |
| Molecular Weight | 20586 Da |
| Protein Sequence Size | 182 |
| Function | |
| Charge | 0.5 |
| Isoelectric Point | 7.2483 pH |
| Description | ADP-ribosylation factor 1 (Adp-ribosylation factor, putative). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q6IMM3|Q6IMM3_LEIMA ADP-ribosylation factor 1 (Adp-ribosylation factor, putative) - Leishmania major. GQWLASAFSSLMGKKEVRIVMVGLDAAGKTTIIYKLKLGEVVTTTPTIGFNVETVEYKNL KFTMWDVGGQQKLRSLWHYYYQGSNGVIFVVDSNDPERMMLAKEELDKILAEEELRNAVL LVFANKQDLPNALTTTQITEKLGLYNVRNRRWYIQGCCATTAQGLYEGLDWLSNNISATM Q |
| DNA Sequence | >LmjF31.2280 |||adp-ribosylation factor, putative|Leishmania major|chr 31|||Manual ATGGGACAGT GGTTGGCCTC CGCCTTCAGC TCCCTTATGG GGAAGAAGGA GGTGCGCATTGTCATGGTCG GTCTAGATGC GGCCGGCAAG ACCACCATCA TCTACAAGCT GAAGCTGGGCGAAGTTGTGA CGACGACGCC GACCATCGGC TTCAACGTTG AGACGGTTGA GTATAAGAACTTGAAATTCA CCATGTGGGA TGTAGGCGGT CAGCAGAAGC TGCGCTCGCT CTGGCATTACTACTACCAGG GCTCCAACGG CGTCATCTTC GTTGTGGACA GCAACGATCC GGAGCGCATGATGCTGGCGA AGGAAGAGCT GGACAAGATC TTGGCCGAGG AGGAGCTGCG TAATGCAGTGCTCCTCGTGT TCGCCAACAA GCAAGATCTG CCGAACGCGC TGACAACGAC GCAGATTACCGAGAAGCTTG GCCTGTACAA CGTCCGCAAT CGCCGGTGGT ACATACAGGG GTGCTGCGCCACGACGGCGC AAGGCCTCTA CGAAGGTCTC GACTGGCTGT CCAACAACAT CTCTGCGACCATGCAATGA |
| ADP-ribosylation factor 1 Q6IMM3] | |
|---|---|
| Metabolite Information | intracellular protein transport; protein transport; small GTPase mediated signal transduction |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K07977 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ADP-ribosylation factor 1 [Homo sapiens] | 69 | 1e-70 | 262 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPL218w GTP-binding protein of the ARF family | Saccharomyces cerevisiae | 34% | 8e-26 | 110 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 24-31; | PS00017 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 176-179; | PS00722 | |
| Acylation | N-myristoylation site | 2-7; 24-29; 157-162; 165-170; | PS00008 | |
| Amidation | Amidation site | 13-16; | PS00009 | |
| Glycosylation | N-glycosylation site | 176-179; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 64-67; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 140-142; | PS00005 | |
| ADP-ribosylation factor 1 [Q6IMM3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1rrgB | |
| Percent Identity | 69% | |
| Target Region | 1-182 | |
| Template Region | 2-177 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ALA | 27 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 146-91-8 | GUANOSINE-5'-DIPHOSPHATE | 443.201 | C10 H15 N5 O11 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 1rrg |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1rrg |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/515664/Q6IMM3.pdb 2.0 182 = residues | | = | +| Ramachandran plot: 91.4% core 8.0% allow 0.6% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 180) = | +| Chi1-chi2 plots: 2 labelled residues (out of 114) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.7 Bad contacts: = 2 | *| Bond len/angle: 5.4 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.00 Covalent: -0.13 Overall: = -0.04 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | | M/c bond angles: 94.4% within limits 5.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |