| Small GTP-binding protein, putative [Q4QJK0] | |
|---|---|
| Systematic Name | LmjF.05.0030 [Leishmania major] |
| Gene Name | LMJF_05_0030 |
| Molecular Weight | 21714 Da |
| Protein Sequence Size | 195 |
| Function | |
| Charge | 2 |
| Isoelectric Point | 7.5026 pH |
| Description | Small GTP-binding protein, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QJK0|Q4QJK0_LEIMA Small GTP-binding protein, putative - Leishmania major. SWFSWLWDWLSYLGLSNKTGKLLFLGLDNAGKTTLLGKLATNQVHVHRPTFHPNSEDLTL GGIKLKTIDMGGHQQARRLWKDYFTKVDGVVFIVDAATPQRFPEAKSELDMLLQSEELAK TPFLILGNKIDMPGCTCSEGQLVMEMGLDGALTGKATPVTDPNVRPLEVYMCSVVKNVGY GDGFRWLSQYLKSS |
| DNA Sequence | >LmjF05.0030 |||small GTP-binding protein, putative|Leishmania major|chr 5|||Manual ATGAGCTGGT TTAGCTGGCT TTGGGACTGG CTGTCCTACT TGGGGCTGTC CAATAAAACAGGCAAACTCC TGTTTCTTGG GCTGGACAAT GCCGGCAAAA CCACCCTTCT TGGCAAGCTGGCAACGAATC AGGTCCACGT TCACCGCCCT ACATTTCACC CTAACTCGGA GGACTTGACTCTGGGGGGCA TCAAGCTCAA AACCATTGAC ATGGGTGGTC ATCAGCAGGC GCGTCGGCTGTGGAAGGATT ACTTCACGAA GGTCGACGGC GTCGTTTTTA TCGTTGACGC AGCGACGCCACAGCGTTTTC CAGAAGCAAA GAGCGAGCTT GATATGCTAC TGCAGTCGGA GGAACTCGCCAAAACGCCGT TCCTGATTTT AGGCAACAAG ATCGACATGC CGGGCTGCAC ATGCTCTGAGGGGCAACTTG TCATGGAGAT GGGTCTGGAT GGTGCACTCA CGGGCAAGGC GACCCCAGTGACAGACCCCA ATGTGCGTCC CCTGGAGGTG TACATGTGCA GCGTAGTCAA GAACGTCGGCTACGGTGACG GCTTCCGCTG GCTCTCACAG TATCTGAAGA GCTCGTAG |
| Small GTP-binding protein, putative Q4QJK0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding |
| Biochemical Pathway | ER to Golgi vesicle-mediated transport; intracellular protein transport; small GTPase mediated signal transduction |
| Regulatory Pathway | |
| KEGG Pathways | K07977 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | SAR1a gene homolog 2 [Homo sapiens] | 51 | 7e-52 | 200 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPL218w GTP-binding protein of the ARF family | Saccharomyces cerevisiae | 54% | 7e-52 | 197 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00161 | Aminoacyl-transfer RNA synthetases class-I signature | 54-64; | PS00178 | |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 27-34; | PS00017 | |
| Acylation | N-myristoylation site | 27-32; 135-140; 148-153; 151-156; | PS00008 | |
| Glycosylation | N-glycosylation site | 18-21; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 86-89; 108-111; 137-140; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 17-19; 20-22; 154-156; | PS00005 | |
| Small GTP-binding protein, putative [Q4QJK0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1f6bB | |
| Percent Identity | 51% | |
| Target Region | 1-195 | |
| Template Region | 13-180 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| HIS | 74 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 146-91-8 | GUANOSINE-5'-DIPHOSPHATE | 443.201 | C10 H15 N5 O11 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 1f6b |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1f6b |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S   | [O-]S([O-])(=O)=O | 1f6b |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/424915/Q4QJK0.pdb 2.0 195 = residues | | = | +| Ramachandran plot: 94.5% core 3.6% allow 1.8% gener 0.0% = disall | | = | *| All Ramachandrans: 6 labelled residues (out of 193) = | +| Chi1-chi2 plots: 1 labelled residues (out of 116) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.4 Bad contacts: = 5 | *| Bond len/angle: 5.4 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.10 Covalent: -0.12 Overall: = 0.02 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | | M/c bond angles: 95.0% within limits 5.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |