| ATP synthase alpha chain [Q4QJF1] | |
|---|---|
| Systematic Name | LmjF.05.0500 [Leishmania major] |
| Gene Name | LMJF_05_0500 |
| Molecular Weight | 62549 Da |
| Protein Sequence Size | 574 |
| Function | |
| Charge | 30.5 |
| Isoelectric Point | 10.12 pH |
| Description | ATP synthase alpha chain. |
| Subcellular Location | proton-transporting ATP synthase complex, catalytic core F(1)[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QJF1|Q4QJF1_LEIMA ATP synthase alpha chain - Leishmania major. RRFVAQYVAPAMGRLASTAAAGKSAAPGQKSFFKATEMIGYVHSIDGTIATLIPAPGNPG VAYNTIIMIQVSPTTFAAGLVFNLEKDGRIGIILMDNITEVQSGQKVMATGKLLYIPVGA GVLGKVVNPLGHEVPVGLLTRSRALLESEQTLGKVDAGAPNIVSRSPVNYNLLTGFKAVD TMIPIGRGQRELIVGDRQTGKTSIAVSTIINQVRSNQQILSKNAVISIYVSIGQRCSNVA RIHRLLRSYGALRYTTVMAATAAEPAGLQYLAPYSGVTMGEYFMNRGRHCLCVYDDLSKQ AVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAMLSPGKGGGSVTALPIVETLSNDV TAYIVTNVISITDGQIYLDTKLFTGGQRPAVNIGLSVSRVGSSAQNVAMKAVAGKLKGIL AEYRKLAADSVGGSQVQTVPMIRGARFVALFNQKNPSFFMNALVSLYACLNGYLDDVKVN YAKLYEYLLVNKDLSVMYGTATNKFFYMYVQQLNYVIRFFTLNHPILNAEVEEMLKQHTH LFLQHYQSKMNAIKTEKEIKALKNLLYSCKRAV |
| DNA Sequence | >LmjF05.0500 |||ATPase alpha subunit|Leishmania major|chr 5|||Manual ATGCGCCGCT TCGTGGCCCA GTACGTGGCG CCCGCCATGG GACGCCTTGC GTCGACGGCTGCTGCCGGCA AGTCTGCCGC GCCGGGCCAG AAGTCGTTCT TCAAGGCGAC GGAGATGATCGGCTACGTGC ACTCGATCGA CGGCACGATC GCGACGCTGA TCCCCGCGCC GGGCAACCCCGGCGTTGCGT ACAACACGAT CATCATGATC CAGGTGAGCC CGACGACGTT CGCGGCGGGGCTTGTGTTCA ACCTGGAGAA GGACGGCCGG ATAGGCATCA TCCTGATGGA TAACATCACGGAGGTGCAGT CCGGCCAGAA GGTGATGGCG ACGGGCAAGC TGCTGTACAT CCCCGTGGGTGCGGGCGTGC TGGGCAAGGT GGTGAACCCG CTGGGCCACG AGGTGCCGGT GGGGCTGTTGACGCGGTCGC GCGCGCTGCT GGAGAGCGAA CAGACGCTGG GCAAGGTGGA CGCCGGCGCGCCGAACATCG TGTCGCGCTC GCCAGTGAAC TACAACCTGC TGACCGGCTT CAAGGCAGTGGACACGATGA TCCCGATCGG GCGCGGCCAG CGCGAGCTGA TCGTGGGTGA CCGCCAGACCGGCAAGACGT CGATCGCGGT GTCGACGATC ATCAACCAGG TGCGCAGCAA CCAGCAGATCCTATCGAAGA ACGCGGTCAT CTCGATCTAC GTGTCGATCG GGCAGCGCTG CTCCAACGTCGCGCGCATCC ACCGCCTGCT GCGCTCGTAC GGCGCGCTGC GCTACACGAC GGTGATGGCTGCGACGGCCG CGGAGCCGGC GGGGCTGCAG TACCTCGCGC CGTACTCGGG CGTGACAATGGGCGAGTACT TCATGAACCG CGGCCGCCAC TGCCTGTGTG TGTACGACGA CCTGTCGAAGCAAGCCGTTG CGTACCGCCA GATCTCGCTG CTGCTGCGCC GCCCGCCGGG CCGCGAGGCGTACCCTGGTG ATGTGTTCTA CCTGCACTCG CGCCTGCTGG AGCGCGCCGC GATGCTGTCGCCTGGCAAGG GCGGCGGCTC CGTGACGGCG CTGCCGATCG TGGAGACGCT GTCGAACGATGTGACGGCGT ACATCGTCAC GAACGTCATC TCCATCACGG ACGGCCAGAT CTACCTGGACACGAAGCTGT TCACCGGCGG CCAGCGCCCG GCCGTGAACA TCGGCCTGTC CGTGTCGCGCGTCGGCTCGT CCGCGCAGAA CGTGGCGATG AAGGCGGTGG CCGGCAAGCT GAAGGGCATCCTCGCGGAGT ACCGCAAGCT GGCGGCGGAC TCGGTGGGCG GGAGCCAGGT GCAGACGGTGCCGATGATCC GCGGCGCGCG CTTCGTCGCG CTGTTCAACC AGAAGAACCC GTCCTTCTTCATGAACGCGC TCGTGTCGCT GTACGCGTGC CTGAACGGGT ACCTGGACGA CGTGAAGGTGAACTACGCGA AGCTCTACGA GTACCTGCTG GTGAACAAGG ACCTGAGCGT GATGTACGGGACAGCGACGA ACAAGTTCTT CTACATGTAC GTGCAGCAGC TGAACTACGT GATCCGCTTCTTCACGCTGA ACCACCCGAT CCTGAACGCG GAGGTGGAGG AGATGCTGAA GCAGCACACGCACCTGTTCC TGCAGCACTA CCAGTCGAAG ATGAACGCGA TCAAGACGGA GAAGGAGATCAAGGCGCTCA AGAACCTGCT GTACTCATGC AAGCGCGCCG TCTAA |
| ATP synthase alpha chain Q4QJF1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; hydrogen-transporting ATP synthase activity, rotational mechanism; hydrogen-transporting ATPase activity, rotational mechanism; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances |
| Biochemical Pathway | ATP biosynthesis; ATP synthesis coupled proton transport |
| Regulatory Pathway | |
| KEGG Pathways | K02111 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursor [Homo sapiens] | 52 | 1e-109 | 392 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| atpA ATP synthase subunit A | Mycobacterium tuberculosis H37Rv | 48% | 1e-103 | 370 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00137 | ATP synthase alpha and beta subunits signature | 390-399; | PS00152 | |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 196-203; | PS00017 | |
| Acylation | N-myristoylation site | 48-53; 61-66; 80-85; 234-239; 277-282; 345-350; 346-351; 387-392; 395-400; 500-505; | PS00008 | |
| Glycosylation | N-glycosylation site | 98-101; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 262-265; 279-282; 371-374; 556-559; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 111-113; 200-202; 503-505; 556-558; 569-571; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 35-42; | PS00007 | |
| ATP synthase alpha chain [Q4QJF1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2qe7C | |
| Percent Identity | 52% | |
| Target Region | 29-574 | |
| Template Region | 27-474 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 174 | Unknown |
| GLN | 207 | Unknown |
| ARG | 208 | Unknown (LYS 201 In Template) |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/402825/Q4QJF1.pdb 2.0 546 = residues | | = | *| Ramachandran plot: 87.7% core 9.2% allow 2.5% gener 0.6% = disall | | = | *| All Ramachandrans: 27 labelled residues (out of 544) = | +| Chi1-chi2 plots: 3 labelled residues (out of 310) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 10 | *| Bond len/angle: 6.7 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: -0.07 Covalent: -0.25 Overall: = -0.13 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 92.2% within limits 7.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |