| Peptidyl-prolyl cis-trans isomerase [Q4QJ67] | |
|---|---|
| Systematic Name | LmjF.06.0120 [Leishmania major] |
| Gene Name | CYP2 |
| Molecular Weight | 20326 Da |
| Protein Sequence Size | 187 |
| Function | |
| Charge | 1.5 |
| Isoelectric Point | 7.0573 pH |
| Description | Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 5.2.1.8 |
| Sequence | >tr|Q4QJ67|Q4QJ67_LEIMA Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) - Leishmania major. RAVAVVAVVLCALSFLNVAAEPEVTSKVYFDVMMDSEPLGRITIGLFGKDAPLTTENFRQ LCTGEHGFGYKDSIFHRVIPNFMIQGGDFTNFDGTGGKSIYGEKFADENLKIKHFVGALS MANAGPNTNGSQFFITTAPTPWLDGRHVVFGKVLDGMDVVLRIEKAKTNSHDRPVKPVKI VASGDL |
| DNA Sequence | >LmjF06.0120 |CYP||cyclophilin|Leishmania major|chr 6|||Manual ATGCGTGCTG TGGCTGTCGT GGCGGTGGTG CTGTGCGCCC TCTCCTTTCT CAACGTCGCCGCGGAGCCGG AGGTGACCTC GAAGGTGTAC TTTGATGTGA TGATGGATAG CGAGCCGCTTGGCCGCATCA CCATCGGCCT GTTCGGCAAG GATGCGCCGC TCACGACAGA GAACTTCCGGCAGCTCTGCA CGGGTGAGCA TGGGTTCGGC TACAAGGACT CCATCTTCCA CCGCGTCATCCCCAACTTCA TGATCCAGGG CGGCGACTTC ACCAACTTCG ATGGCACGGG CGGCAAGTCGATCTACGGCG AAAAGTTTGC GGATGAGAAC TTGAAGATAA AACACTTTGT GGGTGCGCTGTCCATGGCAA ACGCCGGCCC CAACACCAAC GGCTCGCAGT TCTTCATCAC GACAGCGCCGACGCCGTGGC TTGATGGCCG CCATGTGGTG TTCGGCAAGG TGCTTGATGG TATGGACGTGGTGCTTCGCA TCGAGAAGGC AAAGACGAAC AGCCACGATC GCCCGGTGAA GCCTGTAAAGATCGTTGCCA GTGGTGACCT GTAG |
| Peptidyl-prolyl cis-trans isomerase Q4QJ67] | |
|---|---|
| Metabolite Information | |
| Molecular Function | peptidyl-prolyl cis-trans isomerase activity |
| Biochemical Pathway | protein folding |
| Regulatory Pathway | |
| KEGG Pathways | K03768 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | peptidylprolyl isomerase B precursor [Homo sapiens] | 57 | 5e-50 | 194 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| ppiB Peptidyl-prolyl cis-trans isomerase B (EC 5.2.1.8) | Escherichia coli MG1655 | 34% | 0.000000003 | 55.5 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00154 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature & profile | 71-88; | PS00170 | |
| PDOC00154 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature & profile | 43.612 | 30-186; - | PS50072 |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 130-133; | PS00722 | |
| Acylation | N-myristoylation site | 87-92; | PS00008 | |
| Glycosylation | N-glycosylation site | 130-133; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 91-94; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 26-28; | PS00005 | |
| Peptidyl-prolyl cis-trans isomerase [Q4QJ67] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2haqA | |
| Percent Identity | 88% | |
| Target Region | 22-187 | |
| Template Region | 22-166 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ARG | 57 | Sidechain |
| PHE | 62 | Sidechain |
| GLN | 65 | Sidechain |
| ASN | 103 | Sidechain |
| PHE | 114 | Sidechain |
| LEU | 123 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/117837/Q4QJ67.pdb 2.0 166 = residues | | = | +| Ramachandran plot: 89.0% core 8.8% allow 2.2% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 164) = | +| Chi1-chi2 plots: 2 labelled residues (out of 96) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.2 Bad contacts: = 1 | *| Bond len/angle: 10.0 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.02 Covalent: -0.19 Overall: = -0.08 | | = | | M/c bond lengths: 99.0% within limits 1.0% highlighted = | *| M/c bond angles: 93.7% within limits 6.3% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |