| Ras-related protein rab-14, putative [Q4QIN6] | |
|---|---|
| Systematic Name | LmjF.07.0560 [Leishmania major] |
| Gene Name | LMJF_07_0560 |
| Molecular Weight | 24472 Da |
| Protein Sequence Size | 225 |
| Function | |
| Charge | -2.5 |
| Isoelectric Point | 5.8858 pH |
| Description | Ras-related protein rab-14, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QIN6|Q4QIN6_LEIMA Ras-related protein rab-14, putative - Leishmania major. SHKYIFKYIIIGDMSVGKSCLMHLFTEQRYRKDLPHTIGVDFGTTVVDINGELVKLQMWD TAGQERFRSVTRGYYRGAAGALLVYDISRRSTYAHIGTWLTDARANTGPETVFILVGNKS DLEEEREVSYEEAAQFAAEHNLLFVECSSLNGNNVEEVFLSTARRIHEKVKSGVMSPVDP ESGVQLHTAAIPTSTANSGQTGGPVDLKAGTSGGVAAAAESSCC |
| DNA Sequence | >LmjF07.0560 |||ras-related protein rab-14, putative|Leishmania major|chr 7|||Manual ATGAGTCACA AGTATATCTT CAAGTACATC ATCATCGGCG ACATGAGCGT CGGAAAGAGCTGTCTCATGC ACCTGTTCAC GGAGCAGCGG TACCGCAAGG ACCTTCCGCA CACTATCGGTGTCGACTTCG GCACCACGGT CGTCGACATC AACGGTGAGC TCGTGAAGCT GCAGATGTGGGACACCGCCG GGCAAGAACG CTTTCGCTCT GTCACGCGAG GCTACTACCG CGGCGCAGCTGGCGCACTCC TTGTGTATGA CATTAGCCGG CGATCGACGT ACGCCCACAT AGGCACTTGGCTGACCGATG CTCGCGCGAA CACGGGGCCC GAGACGGTCT TCATTCTCGT AGGCAACAAGTCTGACCTGG AGGAGGAGCG AGAGGTGTCG TACGAGGAGG CGGCTCAGTT CGCAGCGGAGCACAATCTGC TTTTTGTGGA GTGCAGCTCG CTAAACGGCA ACAACGTTGA GGAGGTCTTCCTGTCTACGG CGCGCCGCAT TCACGAGAAG GTGAAGAGCG GTGTGATGAG CCCGGTCGATCCGGAGAGTG GCGTGCAGCT GCACACGGCC GCCATTCCCA CCTCGACCGC TAACAGCGGCCAGACTGGGG GTCCAGTGGA CTTGAAGGCC GGCACGAGTG GCGGCGTTGC TGCGGCGGCAGAGTCGAGCT GCTGCTAG |
| Ras-related protein rab-14, putative Q4QIN6] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding |
| Biochemical Pathway | intracellular protein transport; protein transport; small GTPase mediated signal transduction |
| Regulatory Pathway | |
| KEGG Pathways | K07881 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | GTPase Rab14 [Homo sapiens] | 57 | 6e-62 | 234 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL005w GTP-binding protein of the ras superfamily | Saccharomyces cerevisiae | 40% | 3e-38 | 152 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 13-20; | PS00017 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 119-122; | PS00722 | |
| Acylation | N-myristoylation site | 40-45; 78-83; 98-103; 211-216; 214-219; 215-220; | PS00008 | |
| Glycosylation | N-glycosylation site | 119-122; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 90-93; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 46-49; 108-111; 121-124; 130-133; 177-180; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 2-4; 89-91; 163-165; | PS00005 | |
| Ras-related protein rab-14, putative [Q4QIN6] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2aedA | |
| Percent Identity | 59% | |
| Target Region | 1-169 | |
| Template Region | 8-152 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 146-91-8 | GUANOSINE-5'-DIPHOSPHATE | 443.201 | C10 H15 N5 O11 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 2aed |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2aed |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2945460/Q4QIN6.pdb 2.0 169 = residues | | = | *| Ramachandran plot: 90.8% core 8.6% allow 0.0% gener 0.7% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 167) = | +| Chi1-chi2 plots: 2 labelled residues (out of 104) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.1 Bad contacts: = 0 | *| Bond len/angle: 7.0 Morris et al class: 1 = 1 3 | | = | | G-factors Dihedrals: 0.02 Covalent: -0.19 Overall: = -0.06 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 93.2% within limits 6.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |