| Centrin, putative [Q4QIM0] | |
|---|---|
| Systematic Name | LmjF.07.0710 [Leishmania major] |
| Gene Name | LMJF_07_0710 |
| Molecular Weight | 20797 Da |
| Protein Sequence Size | 187 |
| Function | |
| Charge | -12.5 |
| Isoelectric Point | 4.2992 pH |
| Description | Centrin, putative (Caltractin, putative). |
| Subcellular Location | centrosome[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QIM0|Q4QIM0_LEIMA Centrin, putative (Caltractin, putative) - Leishmania major. SIASNTPLRPSTSASNANTELSKDQLEEIREAFDLFDTDGSGTIDVRELRVAMRALGFEP RKEELQQLINSVTGGSGYEATTTRLPSAGNVNASSDVITFSQFVQIMKHKVSQRDSREEM LKAFVLFDTEGTGKISFQNLKRVAVELGENMTDAELQEMIDEADRDGDGEVSEEEFLRLM KKTSLY |
| DNA Sequence | >LmjF07.0710 |||centrin, putative|Leishmania major|chr 7|||Manual ATGAGTATCG CGAGCAACAC ACCTTTAAGG CCGAGCACCT CCGCATCGAA CGCGAACACCGAGCTCAGCA AGGATCAGCT GGAGGAAATC CGCGAGGCGT TCGACTTATT CGACACGGATGGCAGTGGCA CGATCGACGT GCGGGAGCTG CGCGTTGCCA TGCGGGCACT CGGCTTCGAGCCTCGTAAGG AGGAGCTTCA GCAGCTTATC AACAGCGTCA CCGGTGGCAG CGGCTACGAAGCAACCACTA CGCGGCTGCC GAGCGCCGGC AATGTGAACG CGTCCAGCGA CGTGATCACCTTCTCGCAGT TTGTGCAGAT TATGAAGCAC AAGGTGTCAC AACGGGACTC GCGGGAGGAGATGCTGAAGG CGTTCGTGCT CTTCGACACA GAGGGCACTG GCAAGATCTC GTTCCAGAACTTGAAGCGAG TGGCGGTGGA GCTTGGCGAG AACATGACGG ACGCCGAGCT GCAGGAGATGATCGACGAGG CGGACCGTGA CGGGGACGGC GAGGTGAGCG AGGAGGAGTT TCTTCGCTTAATGAAGAAGA CGTCGCTGTA CTAA |
| Centrin, putative Q4QIM0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | calcium ion binding |
| Biochemical Pathway | biological process unknown |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | centrin 1 [Homo sapiens] | 61 | 2e-52 | 202 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YOR257w spindle pole body component, centrin | Saccharomyces cerevisiae | 42% | 8e-32 | 130 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00039 | DEAD and DEAH box families ATP-dependent helicases signatures | 160-168; | PS00039 | |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 38-50; 165-177; | PS00018 | |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 16.996; 12.170; 14.876 | 25-60; 116-151; 152-187 | PS50222 |
| Acylation | N-myristoylation site | 90-95; | PS00008 | |
| Glycosylation | N-glycosylation site | 93-96; 151-154; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 182-185; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 77-80; 113-116; 117-120; 153-156; 173-176; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 83-85; 113-115; 133-135; | PS00005 | |
| Centrin, putative [Q4QIM0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ggmB | |
| Percent Identity | 61% | |
| Target Region | 22-187 | |
| Template Region | 25-144 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 2ggm |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/3487076/Q4QIM0.pdb 2.0 166 = residues | | = | | Ramachandran plot: 94.0% core 6.0% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 164) = | +| Chi1-chi2 plots: 1 labelled residues (out of 107) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.7 Bad contacts: = 3 | *| Bond len/angle: 7.6 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.25 Covalent: -0.09 Overall: = 0.13 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 95.5% within limits 4.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |