| Serine/threonine kinase, putative [Q4QIJ7] | |
|---|---|
| Systematic Name | LmjF.07.0900 [Leishmania major] |
| Gene Name | LMJF_07_0900 |
| Molecular Weight | 33651 Da |
| Protein Sequence Size | 296 |
| Function | |
| Charge | 2 |
| Isoelectric Point | 6.8 pH |
| Description | Serine/threonine kinase, putative (Protein kinase, putative). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QIJ7|Q4QIJ7_LEIMA Serine/threonine kinase, putative (Protein kinase, putative) - Leishmania major. GAPKRLGKYELGRTLGTGNFSKVKIARDTETGKEWAIKVIDKEQLVRERMEEQLKREIAV MKMLRQPNIIELHEVMQTSHHIYLVLELVTGGELFEKIASAKRFDEPTARHYFHQLICGI NYCHRQGIAHRDLKPENLLLDANDTLKISDFGLSNLQRTSVSGGTMLQTVCGTPNYVAPE VLKEQGYDGLKADIWSCGVVLFVMMAGYLPFDDENVNALFTKIERGEFRMARHFSADARD LISRMLTVDPQERISLDDVIAHPWFCVDWNPAMLTRGESHSSPNTTQISNAIRNM |
| DNA Sequence | >LmjF07.0900 |||serine/threonine kinase, putative|Leishmania major|chr 7|||Manual ATGGGTGCCC CCAAGCGTCT CGGCAAGTAC GAGCTGGGCC GTACACTAGG CACTGGCAACTTCTCGAAGG TCAAGATCGC GCGTGACACG GAGACTGGTA AGGAATGGGC CATCAAGGTGATCGACAAGG AGCAGCTCGT GCGGGAGCGC ATGGAGGAGC AGCTGAAGCG CGAGATTGCCGTCATGAAGA TGCTGCGCCA GCCAAACATT ATTGAGCTGC ACGAGGTCAT GCAGACGAGCCATCACATCT ACCTGGTGCT GGAGCTCGTG ACGGGCGGTG AGTTGTTCGA GAAGATCGCCAGCGCGAAGC GCTTCGATGA GCCGACGGCA CGGCACTACT TCCACCAGCT CATCTGTGGCATCAACTACT GCCACCGCCA GGGCATTGCT CATCGTGACT TGAAGCCGGA GAACCTGCTCCTAGATGCGA ACGACACGCT GAAGATTTCT GACTTTGGTC TGAGCAACCT GCAGCGCACGAGCGTGAGCG GCGGCACAAT GCTGCAGACG GTGTGCGGCA CGCCCAATTA TGTCGCCCCGGAGGTGCTGA AGGAGCAAGG CTACGACGGT CTCAAGGCGG ACATCTGGAG CTGCGGTGTGGTGTTGTTCG TCATGATGGC TGGCTACTTA CCATTCGACG ACGAGAACGT TAACGCGCTCTTTACGAAGA TCGAGCGCGG TGAGTTTCGC ATGGCGCGTC ACTTCAGCGC CGACGCGCGCGACTTGATTT CACGCATGTT GACGGTCGAC CCACAGGAGC GTATTTCCCT AGACGATGTGATTGCGCATC CTTGGTTCTG CGTGGACTGG AACCCGGCGA TGCTGACGCG GGGCGAGAGTCATTCCTCGC CAAACACGAC TCAGATCAGC AATGCGATTC GTAATATGTA A |
| Serine/threonine kinase, putative Q4QIJ7] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity |
| Biochemical Pathway | protein amino acid phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K00924 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | BR serine/threonine kinase 1 [Homo sapiens] | 42 | 6e-65 | 244 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPL209c serthr protein kinase | Saccharomyces cerevisiae | 33% | 2e-47 | 183 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00100 | Protein kinases signatures and profile | 16-39; | PS00107 | |
| PDOC00100 | Protein kinases signatures and profile | 129-141; | PS00108 | |
| PDOC00100 | Protein kinases signatures and profile | 53.771 | 10-266 | PS50011 |
| Acylation | N-myristoylation site | 120-125; | PS00008 | |
| Glycosylation | N-glycosylation site | 20-23; 144-147; 285-288; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 32-35; 91-94; 222-225; 256-259; 276-279; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 32-34; 101-103; 109-111; 146-148; | PS00005 | |
| Serine/threonine kinase, putative [Q4QIJ7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2eueB | |
| Percent Identity | 44% | |
| Target Region | 1-275 | |
| Template Region | 48-239 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 133 | Sidechain |
| LYS | 135 | Sidechain |
| ASN | 138 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1199205/Q4QIJ7.pdb 2.0 275 = residues | | = | +| Ramachandran plot: 92.6% core 5.7% allow 1.6% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 273) = | +| Chi1-chi2 plots: 1 labelled residues (out of 180) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.9 Bad contacts: = 5 | *| Bond len/angle: 11.5 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.26 Overall: = -0.06 | | = | *| M/c bond lengths: 99.0% within limits 1.0% highlighted 2 off = graph | *| M/c bond angles: 93.2% within limits 6.8% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |