| Peptidyl-prolyl cis-trans isomerase/rotamase, putative [Q4QII4] | |
|---|---|
| Systematic Name | LmjF.07.1030 [Leishmania major] |
| Gene Name | PIN1 |
| Molecular Weight | 12596 Da |
| Protein Sequence Size | 115 |
| Function | |
| Charge | 1.5 |
| Isoelectric Point | 7.5124 pH |
| Description | Peptidyl-prolyl cis-trans isomerase/rotamase, putative (Ppiase, putative) (EC 5.2.1.8). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 5.2.1.8 |
| Sequence | >tr|Q4QII4|Q4QII4_LEIMA Peptidyl-prolyl cis-trans isomerase/rotamase, putative (Ppiase, putative) (EC 5.2.1.8) - Leishmania major. PTSSWRAEHLLIKHSGSRNPVSRRTGQPTTISYEEAVTELQKWCQSINDGKVTFEEAARQ RSDCSSYARGGDLGVFGPGEMMKPFEDATKSLEVGQVSGIVVTDSGVHIIKRIA |
| DNA Sequence | >LmjF07.1030 |||peptidyl-prolyl cis-trans isomerase/rotamase, putative|Leishmania major|chr 7|||Manual ATGCCCACCT CATCTTGGCG GGCGGAGCAT CTGCTCATCA AGCACAGCGG CAGCCGCAACCCTGTGTCGC GCCGCACCGG GCAGCCTACC ACCATATCGT ACGAGGAAGC CGTCACGGAGCTGCAGAAGT GGTGCCAATC CATCAACGAT GGCAAGGTGA CCTTCGAGGA GGCCGCGCGACAGCGCAGCG ACTGCAGCAG CTACGCCCGC GGCGGCGACT TGGGCGTCTT CGGCCCTGGGGAGATGATGA AGCCATTCGA GGATGCCACA AAGTCTCTTG AGGTGGGGCA GGTGAGCGGCATCGTCGTGA CCGACAGCGG CGTGCACATC ATCAAGCGCA TAGCCTGA |
| Peptidyl-prolyl cis-trans isomerase/rotamase, putative Q4QII4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | isomerase activity; peptidyl-prolyl cis-trans isomerase activity |
| Biochemical Pathway | protein folding |
| Regulatory Pathway | |
| KEGG Pathways | K09578 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 [Homo sapiens] | 50 | 6e-22 | 99 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YJR017c processingtermination factor 1 | Saccharomyces cerevisiae | 52% | 6e-25 | 106 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00840 | PpiC-type peptidyl-prolyl cis-trans isomerase signature and profile | 55-75; | PS01096 | |
| PDOC00840 | PpiC-type peptidyl-prolyl cis-trans isomerase signature and profile | 23.834 | 3-115 | PS50198 |
| Acylation | N-myristoylation site | 27-32; 71-76; 96-101; 100-105; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 33-36; 47-50; 54-57; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 5-7; 23-25; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 60-68; | PS00007 | |
| Peptidyl-prolyl cis-trans isomerase/rotamase, putative [Q4QII4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1j6yA | |
| Percent Identity | 53% | |
| Target Region | 1-115 | |
| Template Region | 1-120 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| HIS | 10 | Sidechain |
| CYS | 65 | Sidechain |
| HIS | 109 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1598380/Q4QII4.pdb 2.0 115 = residues | | = | *| Ramachandran plot: 71.1% core 21.6% allow 3.1% gener 4.1% = disall | | = | *| All Ramachandrans: 22 labelled residues (out of 113) = | *| Chi1-chi2 plots: 2 labelled residues (out of 60) = | | = | +| Main-chain params: 5 better 0 inside 1 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 9 | *| Bond len/angle: 13.5 Morris et al class: 2 = 1 3 | | = | | G-factors Dihedrals: -0.37 Covalent: -0.38 Overall: = -0.36 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | *| M/c bond angles: 91.9% within limits 8.1% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |