| Superoxide dismutase [Q4QIE0] | |
|---|---|
| Systematic Name | LmjF.08.0290 [Leishmania major] |
| Gene Name | FESODA |
| Molecular Weight | 26075 Da |
| Protein Sequence Size | 230 |
| Function | |
| Charge | 3.5 |
| Isoelectric Point | 7.2477 pH |
| Description | Superoxide dismutase (EC 1.15.1.1). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 1.15.1.1 |
| Sequence | >tr|Q4QIE0|Q4QIE0_LEIMA Superoxide dismutase (EC 1.15.1.1) - Leishmania major. FGRAPMKAATATAAVGFSCLCYHTLPHLRYPAELPTLGFNYKDGIQPVMSPRQLELHYSK HHSAYVDKLNTLGKGYEGKTIEEIILATTGINESKVMFNQAAQHFNHSFFWKCLSPGGKP MPKTLENAIAKQFGSVDDFMVSFQQAGVNNFGSGWTWLCVDPQTKELLIDSTSNAGCPLT SGLRPIFTADVWEHAYYKDFENRRADYLKELWQIVDWEFVCHMYERATK |
| DNA Sequence | >LmjF08.0290 |FESODA||iron superoxide dismutase|Leishmania major|chr 8|||Manual ATGTTCGGCC GCGCCCCGAT GAAGGCCGCC ACGGCCACCG CTGCCGTCGG GTTTTCGTGCCTGTGCTACC ATACCCTTCC TCATCTTCGG TACCCGGCCG AGCTGCCGAC GCTTGGCTTCAACTATAAGG ACGGCATCCA GCCCGTCATG AGCCCCCGTC AGCTGGAGCT GCACTACAGCAAGCACCACA GCGCGTACGT GGACAAGTTG AACACGCTCG GCAAGGGCTA TGAGGGGAAGACGATTGAGG AGATCATCTT GGCGACCACC GGCATCAATG AAAGCAAGGT CATGTTCAACCAGGCCGCCC AGCACTTCAA CCATTCCTTC TTCTGGAAGT GCTTGTCGCC TGGTGGCAAGCCGATGCCGA AGACGCTCGA GAATGCAATC GCGAAGCAGT TCGGAAGCGT CGACGACTTCATGGTGTCCT TCCAGCAGGC CGGCGTGAAC AACTTTGGCT CTGGCTGGAC GTGGCTCTGCGTCGATCCCC AGACGAAGGA GCTGCTCATC GACAGCACGA GCAACGCGGG CTGCCCGCTGACCTCTGGCT TGCGCCCCAT CTTCACAGCT GATGTATGGG AGCATGCCTA CTACAAGGACTTCGAGAACC GTCGCGCGGA CTACCTGAAA GAGCTCTGGC AGATCGTCGA CTGGGAATTTGTCTGCCATA TGTATGAGAG GGCCACGAAG TAA |
| Superoxide dismutase Q4QIE0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | metal ion binding; superoxide dismutase activity |
| Biochemical Pathway | superoxide metabolism |
| Regulatory Pathway | |
| KEGG Pathways | K04564 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | manganese superoxide dismutase isoform A precursor [Homo sapiens] | 38 | 1e-31 | 133 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| hemC porphobilinogen deaminase | Staphylococcus aureus | 29% | 0.12 | 30.8 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 74-81; | PS00017 | |
| PDOC00083 | Manganese and iron superoxide dismutases signature | 191-198; | PS00088 | |
| PDOC00013 | Prokaryotic membrane lipoprotein lipid attachment site profile | 10-20; | PS51257 | |
| Acylation | N-myristoylation site | 91-96; 153-158; 177-182; | PS00008 | |
| Glycosylation | N-glycosylation site | 93-96; 107-110; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 81-84; 136-139; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 51-53; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 53-59; | PS00007 | |
| Superoxide dismutase [Q4QIE0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iscB | |
| Percent Identity | 51% | |
| Target Region | 1-230 | |
| Template Region | 1-192 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14343-69-2 | AZIDE ION | 42.02 | N3 | [N-]=[N+]=[N-] | 1isc |
| FE (III) ION | 55.845 | Fe | [Fe+3] | 1isc | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1757392/Q4QIE0.pdb 2.0 230 = residues | | = | *| Ramachandran plot: 92.0% core 5.5% allow 1.5% gener 1.0% = disall | | = | *| All Ramachandrans: 11 labelled residues (out of 228) = | | Chi1-chi2 plots: 0 labelled residues (out of 138) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 5.4 Bad contacts: = 2 | *| Bond len/angle: 5.1 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.07 Covalent: -0.16 Overall: = -0.02 | | = | | M/c bond lengths: 98.9% within limits 1.1% highlighted = | | M/c bond angles: 94.0% within limits 6.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |