| Phosphoribosylpyrophosphate synthetase [Q4QI56] | |
|---|---|
| Systematic Name | LmjF.08.1130 [Leishmania major] |
| Gene Name | LMJF_08_1130 |
| Molecular Weight | 40495 Da |
| Protein Sequence Size | 370 |
| Function | |
| Charge | 4.5 |
| Isoelectric Point | 7.2 pH |
| Description | Phosphoribosylpyrophosphate synthetase (EC 2.7.6.1). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.6.1 |
| Sequence | >tr|Q4QI56|Q4QI56_LEIMA Phosphoribosylpyrophosphate synthetase (EC 2.7.6.1) - Leishmania major. SVSPLCDQLKRIEKAYFYQPGKMTEVHAMSGTVSPHIEKRDYSRPFCLVSGNGNRPLAEA VALLMGTHTHHTSVTQYSNGEVNVRINECVLGADVYIIQSTTGNEIIDINTALMELLLLI RKMRLSNAKSVTVIAPFFGYARQDRKTSLRGPISASVVARMVVKMGVNRLASLDLHSNQI QGFFDNIPVDNLLMAHEFARYLHDQPWFNVDQMVVVSPDAGGVERAKQLADILQVGRIVT IVKRRIAAGKVDTMQSVGEVAGFTCIIVDDMIDTGGTLVKACELLKELGAVRVMACCTHG ILTNPCSDRINNCSALEQLVVSDSIPQEEHQKAIPKLTVLTIAPLIAAVIHRYLNEESVS SLFPPSLAG |
| DNA Sequence | >LmjF08.1130 |||phosphoribosylpyrophosphate synthetase|Leishmania major|chr 8|||Manual ATGTCCGTCT CCCCTCTCTG CGATCAGCTG AAGCGCATCG AGAAGGCGTA CTTCTACCAGCCGGGCAAGA TGACGGAGGT GCATGCGATG AGTGGCACCG TGAGTCCGCA CATAGAGAAGCGTGACTACT CGCGCCCGTT TTGCCTAGTC TCCGGTAACG GGAATCGTCC GCTGGCAGAGGCGGTGGCGC TCCTGATGGG CACTCACACC CACCACACGT CTGTGACGCA GTACTCTAACGGCGAGGTGA ACGTGCGTAT CAACGAGTGT GTGCTCGGCG CTGATGTCTA CATAATTCAGAGCACCACCG GAAACGAGAT TATCGACATT AATACGGCGC TCATGGAGCT GCTCCTGCTGATCCGAAAGA TGCGTCTGAG CAATGCAAAG AGTGTGACCG TCATCGCCCC CTTTTTCGGGTACGCTCGCC AAGACCGAAA GACGAGCCTA CGCGGCCCCA TCTCCGCCTC CGTGGTCGCGCGCATGGTCG TGAAGATGGG CGTAAACCGT CTTGCCTCTC TGGACCTGCA CTCGAACCAGATTCAAGGTT TCTTCGACAA CATTCCGGTG GACAACCTTC TCATGGCGCA CGAGTTTGCGCGGTACCTGC ACGACCAGCC GTGGTTCAAC GTCGATCAAA TGGTGGTTGT CTCGCCTGATGCGGGTGGTG TGGAGCGGGC AAAGCAGCTG GCCGATATTC TGCAGGTCGG CCGCATCGTCACCATCGTGA AGCGGCGCAT TGCGGCTGGA AAGGTGGACA CAATGCAGAG CGTGGGTGAGGTGGCCGGCT TCACCTGTAT CATCGTAGAC GACATGATCG ACACCGGCGG CACACTGGTGAAGGCATGTG AGCTTCTGAA GGAACTCGGC GCGGTGCGCG TGATGGCGTG TTGCACGCACGGCATTCTCA CAAACCCCTG CTCGGATCGC ATCAACAACT GCAGCGCCCT TGAGCAGCTGGTGGTGTCCG ACTCCATCCC GCAGGAGGAG CACCAAAAGG CGATCCCCAA GTTGACGGTGCTCACCATTG CACCCCTTAT CGCGGCCGTC ATTCACCGGT ACTTAAACGA GGAAAGCGTCAGCTCCCTCT TCCCTCCCTC ACTGGCGGGA TAG |
| Phosphoribosylpyrophosphate synthetase Q4QI56] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; ribose phosphate diphosphokinase activity; |
| Biochemical Pathway | nucleoside metabolism; nucleotide biosynthesis; purine ribonucleotide biosynthesis |
| Regulatory Pathway | |
| KEGG Pathways | K00948 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | phosphoribosyl pyrophosphate synthetase 2 [Homo sapiens] | 42 | 1e-58 | 224 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| prs Ribose-phosphate pyrophosphokinase | Staphylococcus aureus | 43% | 8e-66 | 244 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00096 | Purine/pyrimidine phosphoribosyl transferases signature | 266-278; | PS00103 | |
| Acylation | N-myristoylation site | 223-228; | PS00008 | |
| Glycosylation | N-glycosylation site | 313-316; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 146-149; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 79-82; 103-106; 257-260; 315-318; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 149-151; 308-310; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 11-17; | PS00007 | |
| Phosphoribosylpyrophosphate synthetase [Q4QI56] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1ibsB | |
| Percent Identity | 42% | |
| Target Region | 45-364 | |
| Template Region | 7-299 | |
| Domain Information | ||
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| Domains | Start | End |
| Active Site Information | ||
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| Residue | Active Site Number | Functional Part |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
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| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2041050/Q4QI56.pdb 2.0 320 = residues | | = | +| Ramachandran plot: 89.2% core 9.4% allow 1.4% gener 0.0% = disall | | = | *| All Ramachandrans: 10 labelled residues (out of 318) = | +| Chi1-chi2 plots: 1 labelled residues (out of 181) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 5.2 Bad contacts: = 5 | *| Bond len/angle: 5.5 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: -0.04 Covalent: -0.23 Overall: = -0.11 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 92.4% within limits 7.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |