| Calmodulin, putative [Q4QHT2] | |
|---|---|
| Systematic Name | LmjF.09.0910 [Leishmania major] |
| Gene Name | LMJF_09_0910 |
| Molecular Weight | 16825 Da |
| Protein Sequence Size | 149 |
| Function | |
| Charge | -22.5 |
| Isoelectric Point | 3.857 pH |
| Description | Calmodulin, putative. |
| Subcellular Location | flagellum[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QHT2|Q4QHT2_LEIMA Calmodulin, putative - Leishmania major. ADQLSNEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDQDGS GTIDFPEFLTLMARKMQDSDSEEEIKEAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEE VDEMIREADVDGDGQINYEEFVKMMMSK |
| DNA Sequence | >LmjF09.0910 |||calmodulin, putative|Leishmania major|chr 9|||Manual ATGGCGGATC AGCTGTCCAA CGAGCAGATC TCCGAGTTCA AGGAGGCCTT CTCCCTCTTTGACAAGGACG GCGATGGCAC CATCACCACC AAGGAGCTCG GCACCGTCAT GCGCTCGCTCGGCCAGAACC CCACCGAGGC GGAGCTGCAG GACATGATCA ACGAGGTGGA CCAGGACGGCAGCGGCACCA TCGACTTCCC CGAGTTCCTG ACGCTGATGG CGCGTAAGAT GCAGGACTCCGACTCGGAGG AGGAGATCAA GGAGGCGTTC CGCGTGTTCG ACAAGGACGG CAACGGCTTCATCTCCGCCG CGGAGCTGCG CCACGTCATG ACCAACCTCG GCGAGAAGCT CACGGACGAGGAGGTGGACG AGATGATCCG TGAGGCCGAC GTGGATGGCG ACGGCCAGAT CAACTACGAGGAGTTCGTGA AGATGATGAT GAGCAAGTAA |
| Calmodulin, putative Q4QHT2] | |
|---|---|
| Metabolite Information | |
| Molecular Function | calcium ion binding |
| Biochemical Pathway | biological process unknown |
| Regulatory Pathway | |
| KEGG Pathways | K02183 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | calmodulin 3 [Homo sapiens] | 89 | 8e-75 | 275 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YBR109c calmodulin | Saccharomyces cerevisiae | 58% | 9e-48 | 182 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 21-33; 57-69; 94-106; 130-142; | PS00018 | |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 17.136; 14.402; 18.056; 15.518 | 8-43; 44-79; 81-116; 117-149 | PS50222 |
| Acylation | N-myristoylation site | 26-31; 41-46; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 18-21; 29-32; 45-48; 80-83; 82-85; 102-105; 118-121; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 29-31; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 132-146; | PS00003 | |
| Calmodulin, putative [Q4QHT2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2vasB | |
| Percent Identity | 91% | |
| Target Region | 1-149 | |
| Template Region | 3-137 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 58-64-0 | ADENOSINE-5'-DIPHOSPHATE | 427.201 | C10 H15 N5 O10 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 2vas |
| BERYLLIUM TRIFLUORIDE ION | 66.007 | Be F3 | F[Be-](F)F | 2vas | |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 2vas |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2vas |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/903100/Q4QHT2.pdb 2.0 149 = residues | | = | | Ramachandran plot: 94.0% core 6.0% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 147) = | +| Chi1-chi2 plots: 1 labelled residues (out of 103) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 2.0 Bad contacts: = 7 | +| Bond len/angle: 3.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.30 Covalent: 0.02 Overall: = 0.19 | | = | | M/c bond lengths:100.0% within limits 0.0% highlighted = | | M/c bond angles: 96.8% within limits 3.2% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |