| FKBP-type peptidyl-prolyl cis-trans isomerase, putative [Q4QHC5] | |
|---|---|
| Systematic Name | LmjF.10.0890 [Leishmania major] |
| Gene Name | LMJF_10_0890 |
| Molecular Weight | 17295 Da |
| Protein Sequence Size | 159 |
| Function | |
| Charge | 4.5 |
| Isoelectric Point | 9.1 pH |
| Description | FKBP-type peptidyl-prolyl cis-trans isomerase, putative (EC 5.2.1.8). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 5.2.1.8 |
| Sequence | >tr|Q4QHC5|Q4QHC5_LEIMA FKBP-type peptidyl-prolyl cis-trans isomerase, putative (EC 5.2.1.8) - Leishmania major. QKQMNAVDQAFMASLDAKSDVHQLASGMRFKILKKMADTASTKSPNLSDPCSVHYHGSLT NGKVFDSSVDRGHPATFSPSQVIKGWTEALQYMVEGEEWEVYLPPDLAYGTRGAGGVIPP NAALVFKIRLLKVMQGGKPGADGHRKLEQALSKTYAEL |
| DNA Sequence | >LmjF10.0890 |||FKBP-type peptidyl-prolyl cis-trans isomerase, putative|Leishmania major|chr 10|||Manual ATGCAAAAGC AGATGAACGC AGTCGATCAG GCATTCATGG CGAGCCTGGA CGCAAAGTCCGACGTGCATC AGCTGGCCAG CGGCATGCGC TTCAAGATCT TGAAGAAAAT GGCTGACACGGCTTCCACAA AGTCGCCGAA CCTGTCGGAC CCGTGCTCGG TGCACTACCA TGGCTCCCTGACGAATGGCA AGGTGTTCGA CAGCTCCGTG GATCGCGGCC ACCCCGCCAC ATTTTCGCCGAGCCAGGTGA TCAAGGGATG GACGGAGGCC CTCCAGTACA TGGTGGAGGG AGAAGAATGGGAGGTTTACT TGCCGCCGGA TCTCGCGTAC GGCACGCGCG GTGCCGGCGG TGTCATTCCGCCGAATGCGG CTCTCGTGTT CAAGATCCGC CTGCTGAAGG TGATGCAGGG CGGCAAGCCGGGTGCGGACG GCCACAGGAA ACTGGAGCAG GCCCTCTCCA AGACCTACGC CGAGCTTTAA |
| FKBP-type peptidyl-prolyl cis-trans isomerase, putative Q4QHC5] | |
|---|---|
| Metabolite Information | |
| Molecular Function | FK506 binding; peptidyl-prolyl cis-trans isomerase activity |
| Biochemical Pathway | protein folding |
| Regulatory Pathway | |
| KEGG Pathways | K03773 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | PREDICTED: similar to FK506-binding protein 1A [Homo sapiens] | 45 | 2e-16 | 82 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL037w beta-tubulin | Saccharomyces cerevisiae | 34% | 2.7 | 25.4 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00426 | FKBP-type peptidyl-prolyl cis-trans isomerase profile | 26.227 | 49-135 | PS50059 |
| Acylation | N-myristoylation site | 58-63; 111-116; 137-142; | PS00008 | |
| Glycosylation | N-glycosylation site | 47-50; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 68-71; 155-158; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 42-44; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 85-93; | PS00007 | |
| FKBP-type peptidyl-prolyl cis-trans isomerase, putative [Q4QHC5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1jvwA | |
| Percent Identity | 45% | |
| Target Region | 1-159 | |
| Template Region | 33-160 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 67 | Sidechain |
| ILE | 84 | Backbone amide |
| TYR | 110 | Sidechain |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/524412/Q4QHC5.pdb 2.0 159 = residues | | = | | Ramachandran plot: 95.5% core 4.5% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 157) = | *| Chi1-chi2 plots: 3 labelled residues (out of 88) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.5 Bad contacts: = 2 | *| Bond len/angle: 5.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.10 Covalent: -0.22 Overall: = -0.02 | | = | | M/c bond lengths: 98.7% within limits 1.3% highlighted = | | M/c bond angles: 93.0% within limits 7.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |