| Small GTP-binding protein Rab11, putative [Q4QHC3] | |
|---|---|
| Systematic Name | LmjF.10.0910 [Leishmania major] |
| Gene Name | Rab11 |
| Molecular Weight | 23389 Da |
| Protein Sequence Size | 208 |
| Function | |
| Charge | 1 |
| Isoelectric Point | 7.2502 pH |
| Description | Small GTP-binding protein Rab11, putative (Rab11 gtpase, putative). |
| Subcellular Location | endomembrane system; endosome[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QHC3|Q4QHC3_LEIMA Small GTP-binding protein Rab11, putative (Rab11 gtpase, putative) - Leishmania major. EETNLSFKIVLIGDSGVGKSNLMTRYTTNEFNQETPSTIGVEFMTKSVKIESRDAKIQIW DTAGQERFRAISRSIYHGAKGAMLVYDITNQTSFDSIPTWLQELRVFVPATCCIFLIGNK CDLEHLRVVKKEVADRFARENGLSFLETSALERTNVDKAFEWLAKSVYEVVVTPQTREAD RTAPKQGRTVNMNPSESQEAKKSGGCC |
| DNA Sequence | >LmjF10.0910 |||small GTP-binding protein Rab11, putative|Leishmania major|chr 10|||Manual ATGGAGGAGA CCAACCTCAG CTTCAAGATC GTCCTCATTG GCGACAGCGG CGTCGGTAAGTCGAACCTCA TGACGCGGTA CACAACCAAC GAGTTCAACC AGGAAACCCC GTCCACCATCGGCGTAGAGT TTATGACGAA GAGCGTCAAG ATTGAGAGCC GCGATGCGAA GATCCAGATTTGGGACACGG CAGGTCAGGA GCGCTTCCGC GCCATCTCGC GCTCCATCTA CCACGGCGCGAAGGGTGCCA TGCTCGTGTA CGACATCACG AACCAAACCT CCTTCGACTC GATTCCAACGTGGCTGCAGG AGCTGCGCGT CTTTGTGCCG GCCACCTGCT GCATCTTCTT GATTGGCAACAAGTGCGATT TGGAGCACCT GCGCGTTGTG AAGAAGGAAG TCGCGGATCG CTTCGCTCGCGAAAACGGCC TGTCCTTCCT CGAAACGTCT GCGCTGGAGA GGACGAACGT AGACAAGGCCTTCGAGTGGC TCGCCAAGTC CGTCTACGAG GTCGTCGTCA CCCCGCAGAC CCGCGAGGCCGACCGCACGG CGCCGAAGCA AGGCAGGACG GTCAACATGA ACCCCAGCGA AAGCCAGGAAGCCAAGAAGA GCGGTGGCTG CTGCTAA |
| Small GTP-binding protein Rab11, putative Q4QHC3] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding; GTPase activity |
| Biochemical Pathway | endosome transport; intracellular protein transport; protein transport; small GTPase mediated signal transduction; synaptic vesicle uncoating |
| Regulatory Pathway | |
| KEGG Pathways | K07976 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | Ras-related protein Rab-11A [Homo sapiens] | 47 | 2e-51 | 198 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL038c GTP-binding protein of the rab family | Saccharomyces cerevisiae | 43% | 1e-45 | 176 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 14-21; | PS00017 | |
| PDOC00579 | Sigma-54 interaction domain signatures and profile | 10-23; | PS00675 | |
| Acylation | N-myristoylation site | 17-22; 79-84; | PS00008 | |
| Glycosylation | N-glycosylation site | 5-8; 91-94; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 28-31; 93-96; 145-148; 150-153; 155-158; 167-170; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 7-9; 48-50; | PS00005 | |
| Small GTP-binding protein Rab11, putative [Q4QHC3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1yzkA | |
| Percent Identity | 54% | |
| Target Region | 1-171 | |
| Template Region | 8-168 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 522.196 | C10 H17 N6 O13 P3 | O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 1yzk | |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1yzk |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1176762/Q4QHC3.pdb 2.0 171 = residues | | = | | Ramachandran plot: 95.5% core 4.5% allow 0.0% gener 0.0% = disall | | = | | All Ramachandrans: 0 labelled residues (out of 169) = | +| Chi1-chi2 plots: 1 labelled residues (out of 105) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.4 Bad contacts: = 2 | *| Bond len/angle: 5.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.09 Covalent: -0.08 Overall: = 0.03 | | = | | M/c bond lengths:100.0% within limits 0.0% highlighted = | | M/c bond angles: 95.2% within limits 4.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |