| Rab1 small GTP-binding protein, putative [Q4QH98] | |
|---|---|
| Systematic Name | LmjF.10.1160 [Leishmania major] |
| Gene Name | LMJF_10_1160 |
| Molecular Weight | 24576 Da |
| Protein Sequence Size | 216 |
| Function | |
| Charge | 5 |
| Isoelectric Point | 8.2 pH |
| Description | Rab1 small GTP-binding protein, putative. |
| Subcellular Location | endoplasmic reticulum; integral to membrane[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QH98|Q4QH98_LEIMA Rab1 small GTP-binding protein, putative - Leishmania major. ANPNTPGGDCDYIFKIIVIGDSGVGKSSLTVRLSEDVFYKDYASTIAIDFRMHQMNYMDK RVRLQIWDTAGQERFQSVATAFYRGANGVLLCFDLTHRPSFIHLEQWMERVKQQALPGIP CLLVGCKSDEARSSRQVTREEAVAWAQQHNMAFIETSAKEKENVQTAFQQITKFIFEDMK ERNGKTPTAGDNAAGRSQSVNFDRQRSNRKENKCC |
| DNA Sequence | >LmjF10.1160 |||rab1 small GTP-binding protein, putative|Leishmania major|chr 10|||Manual ATGGCCAACC CAAACACGCC CGGCGGTGAC TGCGACTACA TCTTCAAGAT CATTGTCATTGGTGACAGTG GCGTAGGCAA GTCATCCTTG ACGGTGCGCC TCTCCGAAGA TGTCTTCTACAAGGACTACG CCTCCACCAT CGCCATCGAC TTTCGCATGC ACCAGATGAA CTACATGGACAAGCGTGTCC GCCTCCAGAT TTGGGACACG GCCGGCCAGG AGCGCTTTCA GTCTGTCGCCACGGCGTTCT ACCGCGGTGC CAACGGGGTG CTGCTCTGCT TCGACCTCAC CCATCGCCCGTCTTTCATAC ACCTAGAGCA GTGGATGGAA CGCGTGAAGC AGCAGGCGCT GCCCGGTATCCCGTGTCTGC TGGTGGGGTG CAAAAGCGAT GAGGCGCGCT CCAGCCGCCA GGTGACGCGCGAGGAGGCGG TAGCCTGGGC TCAGCAACAC AACATGGCCT TCATCGAGAC GAGCGCGAAGGAGAAGGAGA ATGTGCAGAC GGCCTTCCAG CAGATCACCA AGTTCATCTT CGAGGACATGAAGGAGCGCA ACGGCAAGAC ACCGACGGCT GGAGACAACG CGGCTGGCCG CTCTCAGAGCGTTAACTTCG ATCGCCAGCG GAGCAACCGC AAGGAGAACA AGTGCTGCTA G |
| Rab1 small GTP-binding protein, putative Q4QH98] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding; GTPase activity |
| Biochemical Pathway | intracellular protein transport; protein transport; small GTPase mediated signal transduction |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | RAB13, member RAS oncogene family [Homo sapiens] | 42 | 4e-40 | 161 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL005w GTP-binding protein of the ras superfamily | Saccharomyces cerevisiae | 40% | 2e-38 | 152 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 21-28; | PS00017 | |
| PDOC00579 | Sigma-54 interaction domain signatures and profile | 17-30; | PS00675 | |
| Acylation | N-myristoylation site | 24-29; 89-94; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 139-142; 158-161; 189-192; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 31-33; 97-99; 134-136; 158-160; 208-210; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 33-40; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 33-47; | PS00003 | |
| Rab1 small GTP-binding protein, putative [Q4QH98] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2rhdA | |
| Percent Identity | 46% | |
| Target Region | 8-181 | |
| Template Region | 3-164 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLY | 17 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 146-91-8 | GUANOSINE-5'-DIPHOSPHATE | 443.201 | C10 H15 N5 O11 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 2rhd |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2rhd |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/484974/Q4QH98.pdb 2.0 174 = residues | | = | *| Ramachandran plot: 89.4% core 8.8% allow 1.2% gener 0.6% = disall | | = | *| All Ramachandrans: 6 labelled residues (out of 172) = | | Chi1-chi2 plots: 0 labelled residues (out of 111) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | +| Bond len/angle: 4.0 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.12 Covalent: -0.09 Overall: = 0.04 | | = | | M/c bond lengths:100.0% within limits 0.0% highlighted = | | M/c bond angles: 94.4% within limits 5.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |