| Proteasome subunit alpha type [Q4QH56] | |
|---|---|
| Systematic Name | LmjF.11.0240 [Leishmania major] |
| Gene Name | LMJF_11_0240 |
| Molecular Weight | 27787 Da |
| Protein Sequence Size | 247 |
| Function | |
| Charge | -1.5 |
| Isoelectric Point | 6.0642 pH |
| Description | Proteasome subunit alpha type. |
| Subcellular Location | cytosol; nucleus[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4QH56|Q4QH56_LEIMA Proteasome subunit alpha type - Leishmania major. SYDRAITVFSPDGHLFQVEYAQEAVKKGLAAVGVLGSDCVVIAVEKKSAVKLQDSRTIRK IYKVDAHIYLAFAGLSADARVLINKAQLECQRFSLNYEDTIDVGMLVRYVAGVQQKSTQS GGSRPFGVATVIGGFNEDGKPHLWKTDPSGMCSAWRAVAIGRHDQTVIEYMEKNYKDGML RDECVHFAIKSLLEVVESGSRNIELLVLQYKEERYLTEEELQKFVVEVEKEREEEAAKKK RQAEQE |
| DNA Sequence | >LmjF11.0240 |||proteasome alpha 7 subunit, putative|Leishmania major|chr 11|||Manual ATGAGCTACG ATCGCGCCAT CACGGTCTTC TCCCCGGACG GGCATCTCTT CCAGGTCGAGTACGCTCAGG AGGCCGTGAA GAAGGGCTTG GCGGCGGTCG GCGTGCTCGG TAGCGACTGCGTTGTGATCG CGGTGGAGAA GAAGTCTGCT GTCAAGCTGC AGGACAGCCG CACTATCCGTAAGATCTACA AAGTGGATGC GCACATCTAC CTCGCCTTCG CCGGCCTTTC CGCCGACGCGCGCGTGCTCA TCAACAAGGC GCAGCTCGAG TGCCAGCGCT TCTCGCTCAA CTATGAGGATACCATCGACG TGGGCATGCT CGTGCGCTAC GTGGCGGGGG TGCAGCAGAA GTCGACGCAGAGCGGCGGAA GCCGCCCGTT CGGCGTGGCC ACGGTGATTG GGGGGTTCAA CGAGGACGGCAAGCCACACC TATGGAAGAC AGACCCATCT GGCATGTGCT CTGCCTGGCG TGCCGTCGCCATCGGCCGCC ACGACCAGAC GGTGATTGAG TACATGGAGA AGAACTACAA GGATGGCATGTTGCGCGACG AGTGTGTGCA CTTCGCGATC AAGTCGCTGC TGGAGGTGGT GGAGAGCGGCTCGCGCAACA TCGAGCTACT TGTGCTGCAG TACAAGGAGG AGCGCTACCT GACCGAGGAAGAGCTGCAGA AGTTTGTCGT GGAGGTGGAG AAGGAAAGGG AAGAGGAGGC GGCGAAGAAGAAGCGACAGG CAGAGCAGGA GTAG |
| Proteasome subunit alpha type Q4QH56] | |
|---|---|
| Metabolite Information | |
| Molecular Function | threonine endopeptidase activity |
| Biochemical Pathway | ubiquitin-dependent protein catabolism |
| Regulatory Pathway | |
| KEGG Pathways | K02731 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome alpha 7 subunit [Homo sapiens] | 56 | 4e-67 | 251 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YOL038w 20S proteasome subunit (alpha4) | Saccharomyces cerevisiae | 51% | 1e-62 | 233 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00326 | Proteasome A-type subunits signature | 3-25; | PS00388 | |
| Acylation | N-myristoylation site | 34-39; 151-156; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 167-170; 192-195; 218-221; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 58-60; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 91-105; | PS00003 | |
| Proteasome subunit alpha type [Q4QH56] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruR | |
| Percent Identity | 56% | |
| Target Region | 1-247 | |
| Template Region | 2-243 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2162196/Q4QH56.pdb 2.0 247 = residues | | = | +| Ramachandran plot: 87.1% core 11.6% allow 1.3% gener 0.0% = disall | | = | *| All Ramachandrans: 9 labelled residues (out of 245) = | +| Chi1-chi2 plots: 2 labelled residues (out of 151) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 6.2 Bad contacts: = 2 | *| Bond len/angle: 5.1 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.03 Covalent: -0.13 Overall: = -0.03 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |