| 14-3-3 protein, putative [Q4QH45] | |
|---|---|
| Systematic Name | LmjF.11.0350 [Leishmania major] |
| Gene Name | Lm |
| Molecular Weight | 29145 Da |
| Protein Sequence Size | 253 |
| Function | |
| Charge | -8 |
| Isoelectric Point | 4.9329 pH |
| Description | 14-3-3 protein, putative. |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QH45|Q4QH45_LEIMA 14-3-3 protein, putative - Leishmania major. TNVFKVPEKREELVYTAKIAEQCERHDEILFCMKRAVKMNPRLSSEERNLLSAAYKYIIS ARRACWRSMSSMAHKEDSHKGKTASLFNGFQHQVEKELAEICSDILELLDKYLIPAADND ESKVYYYKLKGDYHRYFAEVESGSDTQKNLALEAYKKASEFTTSLKPTSPIRLGLALNFS VFYYEILRSPDKGCQLARQAFEEALSDPEVLDEEQHKESALIMQLLRDNLALWTEDSRPE GQDDGTAMEELE |
| DNA Sequence | >LmjF11.0350 |||14-3-3 protein, putative|Leishmania major|chr 11|||Manual ATGACCAACG TCTTCAAGGT ACCGGAGAAG CGCGAGGAGC TCGTCTACAC GGCGAAGATCGCCGAGCAGT GCGAGCGCCA CGATGAAATT CTATTCTGCA TGAAGCGCGC TGTCAAGATGAACCCGCGGC TGTCCAGCGA GGAGCGCAAC CTGCTCTCGG CCGCCTACAA GTACATTATCAGTGCCCGCC GCGCTTGCTG GCGCAGCATG AGCTCGATGG CGCACAAGGA AGACAGCCACAAGGGCAAGA CGGCGAGCCT CTTCAACGGC TTCCAGCATC AGGTGGAGAA GGAGTTGGCGGAGATCTGTT CCGACATTCT GGAGCTTCTG GACAAGTACC TCATCCCAGC CGCCGACAACGACGAGAGCA AGGTGTACTA CTACAAGCTC AAGGGCGACT ACCACCGCTA CTTCGCGGAGGTGGAGTCCG GCTCAGATAC GCAGAAGAAC CTTGCCCTGG AGGCGTACAA GAAGGCGTCCGAGTTCACAA CCTCGCTGAA GCCGACCTCG CCGATCCGCC TCGGCCTCGC CCTCAACTTCTCTGTCTTCT ACTACGAAAT TCTGCGCAGC CCCGACAAGG GCTGCCAGCT CGCTCGCCAGGCCTTCGAGG AGGCTCTGAG CGATCCGGAG GTGCTGGATG AGGAACAGCA CAAGGAGTCAGCGCTCATCA TGCAGCTGCT GCGCGACAAC CTCGCTCTCT GGACGGAGGA CTCTCGCCCCGAGGGCCAGG ATGATGGAAC AGCCATGGAG GAGCTCGAGT AA |
| 14-3-3 protein, putative Q4QH45] | |
|---|---|
| Metabolite Information | |
| Molecular Function | protein domain specific binding; protein phosphorylated amino acid binding |
| Biochemical Pathway | DNA damage checkpoint; regulation of mitosis |
| Regulatory Pathway | |
| KEGG Pathways | K06630 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide [Homo sapiens] | 53 | 9e-70 | 260 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| yqfY function unknown, but similar to peptidoglycan acetylation | Bacillus subtilis | 26% | 0.18 | 30.4 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 175-180; 194-199; 242-247; | PS00008 | |
| Glycosylation | N-glycosylation site | 179-182; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 157-160; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 45-48; 143-146; 207-210; 238-241; 247-250; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 17-19; 61-63; 79-81; 147-149; 165-167; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 10-16; 129-137; | PS00007 | |
| 14-3-3 protein, putative [Q4QH45] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2br9A | |
| Percent Identity | 56% | |
| Target Region | 10-239 | |
| Template Region | 3-230 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/205305/Q4QH45.pdb 2.0 226 = residues | | = | +| Ramachandran plot: 97.2% core 2.4% allow 0.5% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 224) = | +| Chi1-chi2 plots: 3 labelled residues (out of 153) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 17.7 Bad contacts: = 1 | *| Bond len/angle: 5.4 Morris et al class: 1 = 1 1 | | = | | G-factors Dihedrals: 0.30 Covalent: -0.04 Overall: = 0.17 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | | M/c bond angles: 96.0% within limits 4.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |