| Pyruvate phosphate dikinase, putative [Q4QGX9] | |
|---|---|
| Systematic Name | LmjF.11.1000 [Leishmania major] |
| Gene Name | LMJF_11_1000 |
| Molecular Weight | 100932 Da |
| Protein Sequence Size | 914 |
| Function | |
| Charge | 18 |
| Isoelectric Point | 8.6318 pH |
| Description | Pyruvate phosphate dikinase, putative (EC 2.7.9.1). |
| Subcellular Location | glycosome[Predict] |
| E. C. Number | 2.7.9.1 |
| Sequence | >tr|Q4QGX9|Q4QGX9_LEIMA Pyruvate phosphate dikinase, putative (EC 2.7.9.1) - Leishmania major. DTVKHVYYFGGSKADGNRDMKMLLGGKGANLAEMVNIGIPVPPGFTITTKVCAAYQQSKT IPDDVITQVKENVRKVEKEMKKSFGDVNSPLLFSVRSGAAASMPGMMDTVLNLGLNRNTV EAWVKRKPAQSRFVYDSYRRFITMYADIVMQVGREDFEHALGEMKEKKDTKFDTDLTAED LKELVGKYLRLFEKKTGTPFPQDPWVQLFAAIRAVFRSWGNPRAEMYRRLNHITGLIGTA VNVQAMVFGNVNDRSATGVAFSRSPATGANYFYGEYLVNAQGEDVVAGIRTPQQIGKELS LKWAKEHNVSEEERRRRYPSMEEFMPENYKLLCSIRARLEDHYRDMQDIEFTVEDGRLWM LQCRNGKRTIQAALKVAIDMHQEGRITKEEAVLRVDPEQVGHLLHPNIEPGAAKTAKPIG KGLAASPGAAVGQVVFDAESAKAWAAQGKRVIMVRLETSPEDLAGMNAAQGILTARGGMT SHAAVVARGMGKCCVSGCGDLVLKGKSFTLNGHQFVEGDVITLDGTRGLIYKGALKLRAA SLEGDFKVFVRWCQDVKRLGVRANADTPADANKAREFGAEGVGLCRTEHMFFESDRIDSI REMILADTREGRETALKKLLPIQRGDFIGLFRAMAGNPVVIRLLDPPLHEFVPHDESAQQ ELAAKLGVSAEKVRQRVKALHEMNPMLGLRGCRLGITYPEIYNMQVRAIMEAALTLAKEG TDVQPEIMIPLVGKKEELTFSKKQAVVTAEKVLEEGGARVHYTIGTMIEVPRAALTADQI AEEADFFSFGTNDLTQMGCGFSRDDAGQFLRLYDNLGIYTRDPFQSLDQEGVGLLVSTAV TKGRAVKPTMKMGICGEHGGDPRTIEFCHRVGLNYVSCSPFRVPVAIVAAAHAAVKEKQD YEKRNKALAGSKL |
| DNA Sequence | >LmjF11.1000 |||pyruvate phosphate dikinase, putative|Leishmania major|chr 11|||Manual ATGGACACCG TTAAGCACGT CTACTACTTT GGCGGGTCGA AGGCCGATGG AAACCGTGACATGAAGATGC TTCTCGGCGG CAAGGGTGCG AACCTTGCTG AAATGGTGAA CATCGGCATCCCGGTGCCCC CCGGCTTCAC GATCACGACA AAGGTATGTG CCGCCTACCA GCAGTCAAAGACCATCCCGG ACGATGTGAT TACCCAGGTG AAGGAGAACG TGCGGAAGGT CGAGAAGGAGATGAAGAAGT CCTTCGGCGA TGTCAACTCG CCGCTGCTCT TCTCCGTCCG CTCTGGCGCGGCAGCGTCCA TGCCGGGTAT GATGGACACG GTCCTGAACC TTGGCCTCAA CCGTAACACCGTCGAGGCGT GGGTAAAGCG CAAGCCTGCT CAGTCCCGCT TCGTGTACGA TTCGTACCGCCGCTTCATCA CCATGTACGC GGATATCGTC ATGCAGGTCG GCCGCGAGGA CTTCGAGCACGCACTCGGGG AGATGAAGGA AAAGAAGGAC ACCAAGTTCG ACACGGACCT GACGGCTGAAGACCTCAAGG AGCTTGTAGG CAAGTACCTG CGTCTCTTCG AGAAGAAGAC GGGAACCCCGTTCCCGCAGG ACCCGTGGGT GCAACTGTTT GCTGCCATCC GCGCCGTCTT CCGCAGCTGGGGCAACCCGC GCGCCGAGAT GTACCGGCGC CTGAACCACA TCACCGGCCT GATCGGCACGGCTGTGAACG TGCAGGCGAT GGTGTTCGGT AACGTGAATG ATCGCTCCGC CACTGGCGTTGCCTTCTCTC GCAGCCCGGC CACCGGCGCG AACTACTTCT ACGGCGAGTA CCTGGTGAACGCCCAGGGCG AGGACGTCGT GGCCGGCATC CGCACGCCGC AGCAAATTGG CAAGGAGCTGTCCCTCAAGT GGGCCAAGGA GCACAACGTG AGCGAGGAGG AGCGCAGGCG CCGCTATCCGTCCATGGAGG AGTTCATGCC GGAGAACTAC AAGCTGCTGT GCAGCATCCG GGCGCGTCTGGAGGACCACT ACCGCGACAT GCAAGATATC GAGTTCACCG TGGAGGATGG CCGCCTGTGGATGCTGCAGT GCCGTAACGG CAAGCGCACG ATCCAGGCCG CGCTCAAAGT CGCCATCGACATGCACCAGG AGGGTCGCAT CACCAAGGAG GAAGCCGTGC TGCGCGTTGA CCCCGAGCAGGTGGGCCACC TGCTGCACCC GAACATCGAG CCGGGGGCGG CCAAGACGGC CAAGCCGATCGGCAAGGGCC TCGCGGCGTC CCCGGGCGCG GCCGTCGGCC AGGTCGTCTT CGACGCCGAGTCCGCCAAGG CGTGGGCGGC GCAGGGCAAA CGGGTTATCA TGGTGCGCCT CGAAACCTCTCCGGAGGACC TAGCCGGCAT GAACGCTGCT CAGGGTATTC TGACCGCTCG CGGTGGCATGACCTCGCACG CGGCTGTGGT GGCCCGTGGT ATGGGCAAGT GCTGCGTTTC CGGTTGCGGCGACCTTGTGC TCAAGGGCAA GAGCTTCACG CTGAACGGCC ACCAGTTCGT CGAAGGCGACGTCATCACGC TCGATGGCAC TCGCGGCCTG ATCTACAAGG GTGCGCTGAA GCTGCGCGCCGCGTCGCTCG AGGGCGACTT CAAGGTGTTT GTGCGTTGGT GTCAAGACGT GAAGCGCCTGGGCGTCCGTG CCAACGCCGA TACGCCGGCG GATGCTAACA AGGCTCGCGA ATTCGGCGCTGAGGGTGTGG GTCTGTGCCG CACGGAGCAC ATGTTCTTCG AGTCGGACCG CATCGACTCCATCCGTGAGA TGATCCTCGC CGATACGAGG GAGGGCCGCG AGACGGCGCT CAAGAAGCTGCTGCCCATCC AGCGCGGCGA CTTCATCGGT CTCTTCCGCG CCATGGCTGG CAACCCGGTTGTGATCCGCC TGCTCGACCC CCCGCTGCAC GAGTTCGTGC CACACGACGA GTCTGCCCAGCAGGAGCTGG CCGCCAAGCT TGGCGTCTCG GCGGAGAAGG TGCGCCAGCG CGTCAAGGCCCTGCACGAGA TGAACCCCAT GCTCGGCCTG CGCGGCTGCC GCCTCGGTAT TACCTACCCCGAGATCTACA ATATGCAGGT GCGCGCCATC ATGGAGGCCG CGCTCACTCT GGCGAAGGAGGGCACCGATG TGCAGCCGGA AATCATGATT CCACTTGTGG GCAAGAAGGA GGAGCTGACCTTCTCAAAGA AGCAGGCCGT TGTGACGGCC GAGAAGGTGC TCGAGGAAGG CGGTGCTCGCGTGCACTACA CCATCGGTAC CATGATCGAG GTGCCACGTG CGGCGCTGAC GGCGGACCAGATCGCTGAGG AGGCGGACTT CTTCTCCTTC GGCACAAACG ACCTGACCCA GATGGGTTGCGGCTTCTCTC GTGATGATGC TGGCCAGTTC CTGCGCCTGT ACGACAACCT CGGCATCTACACCCGCGACC CCTTCCAGTC TCTCGACCAA GAGGGCGTTG GCTTGCTCGT CAGCACCGCCGTCACCAAGG GCCGCGCTGT GAAGCCGACG ATGAAGATGG GCATCTGCGG CGAGCACGGCGGTGACCCGC GCACCATCGA GTTCTGCCAC CGCGTGGGCC TGAACTACGT CTCTTGCTCTCCGTTCCGTG TGCCAGTCGC CATTGTGGCC GCCGCCCACG CCGCTGTAAA GGAGAAGCAGGACTACGAGA AGCGCAACAA GGCTCTGGCT GGCTCTAAGC TGTAA |
| Pyruvate phosphate dikinase, putative Q4QGX9] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; kinase activity; pyruvate, phosphate dikinase activity; transferase activity, transferring phosphorus-containing groups |
| Biochemical Pathway | phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K01006 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | AP1 gamma subunit binding protein 1 isoform 2 [Homo sapiens] | 21 | 2 | 32 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| ptsI phosphoenolpyruvate-protein phosphatase | Staphylococcus aureus | 26% | 4e-25 | 111 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 625-627; | PS00016 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 912-914; | PS00342 | |
| PDOC00527 | PEP-utilizing enzymes signatures | 478-489; | PS00370 | |
| Acylation | N-myristoylation site | 11-16; 26-31; 29-34; 99-104; 106-111; 115-120; 221-226; 236-241; 239-244; 259-264; 412-417; 429-434; 466-471; 472-477; 478-483; 490-495; 561-566; 582-587; 584-589; 630-635; 689-694; 692-697; 799-804; 834-839; | PS00008 | |
| Amidation | Amidation site | 366-369; 448-451; 733-736; | PS00009 | |
| Glycosylation | N-glycosylation site | 309-312; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 168-171; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 13-16; 61-64; 84-87; 171-174; 178-181; 311-314; 321-324; 353-356; 388-391; 459-462; 460-463; 568-571; 600-603; 698-701; 767-770; 803-806; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 3-5; 49-51; 95-97; 138-140; 301-303; 335-337; 416-418; 441-443; 475-477; 595-597; 600-602; 742-744; 850-852; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 337-344; | PS00007 | |
| Pyruvate phosphate dikinase, putative [Q4QGX9] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1h6zA | |
| Percent Identity | 75% | |
| Target Region | 1-904 | |
| Template Region | 1-898 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| HIS | 483 | Sidechain |
| CYS | 856 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2307931/Q4QGX9.pdb 2.0 904 = residues | | = | *| Ramachandran plot: 91.6% core 6.9% allow 1.3% gener 0.3% = disall | | = | *| All Ramachandrans: 32 labelled residues (out of 902) = | +| Chi1-chi2 plots: 3 labelled residues (out of 527) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 19.1 Bad contacts: = 15 | *| Bond len/angle: 8.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.03 Covalent: -0.17 Overall: = -0.04 | | = | *| M/c bond lengths: 99.3% within limits 0.7% highlighted 1 off = graph | | M/c bond angles: 93.7% within limits 6.3% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |