| Arginine N-methyltransferase-like protein [Q4QGG2] | |
|---|---|
| Systematic Name | LmjF.12.1270 [Leishmania major] |
| Gene Name | LMJF_12_1270 |
| Molecular Weight | 39459 Da |
| Protein Sequence Size | 343 |
| Function | |
| Charge | -5.5 |
| Isoelectric Point | 5.4157 pH |
| Description | Arginine N-methyltransferase-like protein. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QGG2|Q4QGG2_LEIMA Arginine N-methyltransferase-like protein - Leishmania major. SSAKEYEEAAAEGTMVKTTANKDYYFDSYSHYGIHMEMLKDYQRTTAYRDAIWRNAYMFK NKVVLDVGCGTGILSMFAARAGARKVIGIDCSNVAVQARRIVQDNGFSDVITIIQGKVEE LHLNEKVDIIISEWMGYFLLYESMLNTVLYARDRWGAPDVKILPNRANMYACGITDPQYI EQKFDIWKNVNGLDFSYFKRLSYIEPLIDTVDPEQIITDIVPFFSFDINEVTEAELSFTR TFTLEAKKGDFVHAISVHFDTPFYAGHDPVVLNTSPMVSPTHWRQTVLYIFHPLIMKRGE KANFTMKCVPNPGNPRDLDISLRIDFDGELQACHYDQDFRLR |
| DNA Sequence | >LmjF12.1270 |||arginine N-methyltransferase-like protein|Leishmania major|chr 12|||Manual ATGTCCTCGG CGAAAGAGTA TGAGGAGGCC GCGGCGGAGG GGACCATGGT GAAGACAACAGCAAACAAGG ATTACTACTT CGACTCCTAC AGCCACTACG GCATTCACAT GGAGATGCTGAAAGACTACC AGCGCACGAC GGCCTATCGC GATGCGATCT GGCGTAACGC GTACATGTTCAAGAACAAGG TCGTCCTTGA CGTTGGCTGC GGTACTGGTA TTCTCTCCAT GTTTGCTGCCCGTGCGGGTG CGCGCAAGGT CATCGGCATC GACTGCAGTA ATGTGGCGGT GCAGGCACGTCGGATTGTGC AGGACAACGG CTTCAGCGAC GTCATCACCA TTATCCAAGG CAAAGTTGAGGAGCTGCACC TGAATGAGAA GGTGGACATT ATCATTAGCG AGTGGATGGG CTACTTCCTCCTGTACGAGT CCATGCTGAA CACAGTCCTC TACGCGCGTG ACCGCTGGGG TGCGCCGGATGTGAAGATTC TGCCTAACAG AGCCAACATG TACGCATGCG GCATCACGGA CCCCCAGTACATCGAGCAGA AGTTCGACAT CTGGAAGAAC GTAAATGGGC TCGACTTCTC CTACTTCAAGCGCCTCAGCT ACATTGAGCC CCTCATCGAC ACCGTCGACC CGGAGCAGAT CATCACCGACATTGTCCCTT TCTTCTCCTT CGACATCAAC GAGGTGACGG AGGCAGAGTT GTCTTTCACGAGAACCTTCA CACTGGAGGC GAAGAAGGGC GACTTTGTGC ACGCCATCTC AGTCCACTTCGACACCCCAT TCTACGCAGG CCATGATCCA GTGGTGCTGA ACACGTCACC AATGGTGTCGCCCACGCACT GGCGGCAGAC GGTGCTCTAC ATCTTCCATC CGCTGATCAT GAAGCGGGGCGAGAAGGCGA ACTTCACGAT GAAGTGTGTG CCGAACCCGG GAAATCCGCG GGACCTTGACATTTCTCTGC GCATCGACTT TGATGGTGAG CTGCAGGCGT GCCACTACGA CCAAGACTTCCGCCTCCGGT AA |
| Arginine N-methyltransferase-like protein Q4QGG2] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00599 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | HMT1 hnRNP methyltransferase-like 2 isoform 1 [Homo sapiens] | 51 | 2e-88 | 322 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| prmA ribosomal protein L11 methyltransferase | Haemophilus influenzae | 32% | 0.0000006 | 49.3 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 69-74; 89-94; 193-198; | PS00008 | |
| Glycosylation | N-glycosylation site | 304-307; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 200-203; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 3-6; 203-206; 233-236; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 3-5; 306-308; 322-324; | PS00005 | |
| Arginine N-methyltransferase-like protein [Q4QGG2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1oriA | |
| Percent Identity | 51% | |
| Target Region | 29-343 | |
| Template Region | 38-316 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLU | 106 | Sidechain |
| GLU | 115 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| S-ADENOSYL-L-HOMOCYSTEINE | 384.411 | C14 H20 N6 O5 S | O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 1ori | |
| UNKNOWN | 103.12 | C4 H9 N O2 | O=C(O)C(N)CC | 1ori | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/3724335/Q4QGG2.pdb 2.0 315 = residues | | = | *| Ramachandran plot: 91.8% core 7.4% allow 0.4% gener 0.4% = disall | | = | +| All Ramachandrans: 7 labelled residues (out of 313) = | +| Chi1-chi2 plots: 4 labelled residues (out of 205) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 1 | *| Bond len/angle: 5.9 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: -0.03 Covalent: -0.18 Overall: = -0.08 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 92.5% within limits 7.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |