| Proteasome subunit alpha type [Q4QFV4] | |
|---|---|
| Systematic Name | LmjF.14.0310 [Leishmania major] |
| Gene Name | LMJF_14_0310 |
| Molecular Weight | 32139 Da |
| Protein Sequence Size | 285 |
| Function | |
| Charge | -6.5 |
| Isoelectric Point | 5.3 pH |
| Description | Proteasome subunit alpha type. |
| Subcellular Location | proteasome core complex (sensu Eukaryota); proteasome core complex, alpha-subunit complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4QFV4|Q4QFV4_LEIMA Proteasome subunit alpha type - Leishmania major. SHRYDSRTTTFSPEGRLYQVEYAVEAIQQAGTVIGVCTKDGVVLAGEKMVPHPLFDSENM QDKNISGEKMYKIAEHIGCSVAGVTSDAYALLNYARLSALRHQYTFQEPIAIEDLCRILC DEKQLYTQYGGVRPYGVSFLLVGWDRYYGYQLYSTEPSGDYSAWSAYAIGQNDQVAHSLL KKDWHENMTLEDGMLLALRVLGKTMDTAKIDLGRVEVAVMRKVPASNVDQLLEPFKHHPK TAPQFQILAPSELKPHAERADQAREAEEQAEAERQRQQEQALES |
| DNA Sequence | >LmjF14.0310 |||proteasome alpha 3 subunit, putative|Leishmania major|chr 14|||Manual ATGTCTCACC GGTACGACTC CCGCACCACC ACCTTCTCCC CTGAGGGTCG CCTCTACCAGGTGGAGTACG CCGTGGAGGC GATTCAGCAG GCCGGCACCG TCATCGGCGT ATGCACGAAAGACGGCGTCG TGCTGGCGGG TGAGAAGATG GTGCCGCACC CGCTCTTTGA TAGCGAAAACATGCAAGACA AGAACATCAG CGGGGAAAAG ATGTACAAGA TCGCTGAGCA CATCGGCTGCAGCGTGGCGG GTGTGACGTC TGATGCGTAC GCCTTGCTGA ACTACGCTAG GCTTTCGGCACTGCGCCACC AGTACACCTT CCAGGAGCCG ATAGCGATCG AGGATCTCTG CCGCATCCTGTGTGACGAGA AGCAGCTCTA CACGCAGTAC GGCGGTGTGC GCCCCTACGG TGTCTCCTTCCTGCTTGTTG GATGGGACCG CTATTATGGT TATCAGCTCT ACTCCACCGA GCCGAGTGGCGACTACAGCG CCTGGAGCGC GTACGCGATC GGACAGAACG ACCAAGTGGC GCACTCACTCTTGAAGAAGG ACTGGCACGA GAACATGACG CTAGAGGACG GCATGCTGCT GGCGCTGCGGGTGCTGGGCA AGACGATGGA CACGGCAAAG ATCGACCTCG GCCGGGTGGA GGTGGCGGTGATGCGCAAAG TGCCCGCTTC GAACGTTGAT CAGCTGCTCG AGCCGTTCAA ACACCACCCCAAGACGGCGC CTCAGTTTCA GATTCTCGCC CCTAGTGAAC TGAAGCCGCA CGCCGAACGCGCCGACCAGG CCAGGGAGGC GGAGGAGCAG GCCGAGGCGG AGCGCCAGCG CCAGCAGGAGCAGGCTCTGG AGTCGTAA |
| Proteasome subunit alpha type Q4QFV4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | threonine endopeptidase activity |
| Biochemical Pathway | ubiquitin-dependent protein catabolism |
| Regulatory Pathway | |
| KEGG Pathways | K02728 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome alpha 4 subunit [Homo sapiens] | 49 | 2e-62 | 236 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YGR253c 20S proteasome subunit (alpha5) | Saccharomyces cerevisiae | 38% | 3e-41 | 162 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 198-205; | PS00017 | |
| PDOC00326 | Proteasome A-type subunits signature | 5-27; | PS00388 | |
| Acylation | N-myristoylation site | 32-37; 42-47; 79-84; 194-199; | PS00008 | |
| Glycosylation | N-glycosylation site | 65-68; 188-191; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 106-109; 190-193; 227-230; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 2-4; 208-210; | PS00005 | |
| Proteasome subunit alpha type [Q4QFV4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruQ | |
| Percent Identity | 49% | |
| Target Region | 1-286 | |
| Template Region | 2-250 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1065820/Q4QFV4.pdb 2.0 285 = residues | | = | *| Ramachandran plot: 90.9% core 8.7% allow 0.0% gener 0.4% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 283) = | | Chi1-chi2 plots: 0 labelled residues (out of 174) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 1 | *| Bond len/angle: 5.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.11 Covalent: -0.17 Overall: = 0.01 | | = | | M/c bond lengths: 98.7% within limits 1.3% highlighted = | | M/c bond angles: 94.2% within limits 5.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |