| Ecotin, putative [Q4QFD4] | |
|---|---|
| Systematic Name | LmjF.15.0510 [Leishmania major] |
| Gene Name | LmjF15.0510 |
| Molecular Weight | 17847 Da |
| Protein Sequence Size | 158 |
| Function | |
| Charge | 7 |
| Isoelectric Point | 10.4 pH |
| Description | Ecotin, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QFD4|Q4QFD4_LEIMA Ecotin, putative - Leishmania major. PAGMSDAAGKTLADFKAPYPEPTSQQRRYVIFLDPKGDSKELNDYKVELIPGRVEKVDGT NVYRMGGNIEERTIDGWGYPYYIVTLTTMSGTLMMPLGDAALKRPRFVAMNTKNLYRYNS RLPIVVYMPKDGELRYRIWTVKSTGSGTAKSTKAREM |
| DNA Sequence | >LmjF15.0510 |||ecotin, putative|Leishmania major|chr 15|||Manual ATGCCCGCAG GGATGTCCGA CGCCGCTGGA AAGACACTCG CCGACTTCAA GGCGCCGTACCCGGAGCCGA CGTCGCAGCA GCGCCGATAC GTGATCTTCC TCGACCCCAA GGGCGACAGCAAGGAGCTGA ACGACTACAA GGTGGAGCTG ATCCCTGGCC GTGTCGAAAA GGTGGATGGCACCAATGTAT ACCGCATGGG CGGCAACATC GAGGAGAGGA CTATCGATGG CTGGGGCTACCCCTACTACA TCGTGACACT GACGACGATG TCGGGGACGC TGATGATGCC CCTCGGCGATGCAGCGCTCA AGAGGCCGCG TTTTGTGGCG ATGAACACGA AAAACCTCTA CCGCTACAACAGCCGGCTGC CCATCGTGGT GTACATGCCG AAGGACGGTG AGCTGCGCTA CCGCATCTGGACCGTCAAGA GCACAGGCAG CGGCACGGCC AAGAGCACCA AGGCAAGGGA GATGTGA |
| Ecotin, putative Q4QFD4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | serine-type endopeptidase inhibitor activity |
| Biochemical Pathway | regulation of proteolysis |
| Regulatory Pathway | |
| KEGG Pathways | K08276 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | aquarius [Homo sapiens] | 28 | 1.9 | 29 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YNR016c acetyl-CoA carboxylase | Saccharomyces cerevisiae | 52% | 0.93 | 26.9 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 4-9; 146-151; 148-153; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 12-15; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 141-143; 149-151; 152-154; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 73-80; 131-137; | PS00007 | |
| Ecotin, putative [Q4QFD4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1ezuB | |
| Percent Identity | 40% | |
| Target Region | 10-159 | |
| Template Region | 203-342 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 1ezu |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2991690/Q4QFD4.pdb 2.0 149 = residues | | = | +| Ramachandran plot: 88.0% core 10.4% allow 1.6% gener 0.0% = disall | | = | *| All Ramachandrans: 5 labelled residues (out of 147) = | | Chi1-chi2 plots: 0 labelled residues (out of 89) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.1 Bad contacts: = 3 | +| Bond len/angle: 4.5 Morris et al class: 1 = 1 3 | | = | | G-factors Dihedrals: 0.07 Covalent: -0.19 Overall: = -0.03 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 93.9% within limits 6.1% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |