| Protein tyrosine phosphatase-like protein [Q4QEZ7] | |
|---|---|
| Systematic Name | LmjF.16.0230 [Leishmania major] |
| Gene Name | LMJF_16_0230 |
| Molecular Weight | 19376 Da |
| Protein Sequence Size | 175 |
| Function | |
| Charge | 6.5 |
| Isoelectric Point | 8.3 pH |
| Description | Protein tyrosine phosphatase-like protein. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QEZ7|Q4QEZ7_LEIMA Protein tyrosine phosphatase-like protein - Leishmania major. EVNATLIDCCDPQKPSRVLFHFLILDAPSPSNLPTYIKELQHRGVRHLVRVCGPTYDATL VKSRGIDVHSWPFDDGAPPTRAVLDSWLKLLDTELARQQEDPSVPPPTIGVHCVAGLGRA PILVALALVEYGNVSALDAIALIREKRKGAINQTQMHWITKYKRRHQGAGCVIM |
| DNA Sequence | >LmjF16.0230 |||protein tyrosine phosphatase-like protein|Leishmania major|chr 16|||Manual ATGGAGGTGA ACGCTACGCT GATCGACTGC TGCGACCCGC AGAAGCCGTC GAGGGTGCTCTTTCACTTTC TCATCCTCGA CGCGCCGTCC CCCAGCAACC TCCCGACATA CATCAAGGAGCTGCAGCACC GCGGCGTGCG GCACTTGGTG CGGGTATGCG GCCCGACCTA CGACGCCACCCTTGTCAAGA GCAGGGGCAT TGATGTCCAC AGCTGGCCAT TCGACGACGG CGCGCCTCCGACGCGTGCGG TGCTTGACAG CTGGCTGAAG CTGCTCGACA CGGAGCTTGC GCGTCAGCAGGAGGATCCCT CCGTGCCTCC GCCAACCATC GGCGTGCACT GCGTGGCGGG CCTGGGCCGCGCACCAATCT TGGTGGCGCT GGCGCTGGTG GAGTACGGCA ACGTATCTGC ACTAGACGCTATCGCACTGA TCCGCGAGAA GCGCAAGGGT GCAATTAATC AGACACAGAT GCACTGGATCACCAAGTACA AGCGTCGCCA CCAGGGTGCG GGCTGCGTGA TCATGTAG |
| Protein tyrosine phosphatase-like protein Q4QEZ7] | |
|---|---|
| Metabolite Information | |
| Molecular Function | phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity |
| Biochemical Pathway | protein amino acid dephosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K01104 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein tyrosine phosphatase type IVA, member 1 [Homo sapiens] | 48 | 3e-32 | 134 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFR028c dual specificity phosphatase | Saccharomyces cerevisiae | 26% | 0.000002 | 46.2 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00323 | Tyrosine specific protein phosphatases signature and profiles | 15.312 | 86-159 | PS50056 |
| Acylation | N-myristoylation site | 77-82; 133-138; | PS00008 | |
| Glycosylation | N-glycosylation site | 4-7; 134-137; 153-156; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 6-9; 136-139; | PS00006 | |
| Prenylation | Prenyl group binding site (CAAX box) | 172-175; | PS00294 | |
| Protein tyrosine phosphatase-like protein [Q4QEZ7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1zckC | |
| Percent Identity | 48% | |
| Target Region | 13-170 | |
| Template Region | 9-151 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 64 | Sidechain |
| CYS | 102 | Sidechain |
| ARG | 108 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 71-50-1 | ACETIC ACID | 60.052 | C2 H4 O2 | O=C(O)C | 1zck |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/789786/Q4QEZ7.pdb 2.0 158 = residues | | = | +| Ramachandran plot: 91.7% core 7.5% allow 0.8% gener 0.0% = disall | | = | *| All Ramachandrans: 5 labelled residues (out of 156) = | +| Chi1-chi2 plots: 1 labelled residues (out of 91) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.8 Bad contacts: = 3 | *| Bond len/angle: 5.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.04 Covalent: -0.17 Overall: = -0.04 | | = | | M/c bond lengths: 99.1% within limits 0.9% highlighted = | | M/c bond angles: 93.5% within limits 6.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |