| Protein tyrosine phosphatase-likie protein [Q4QEZ5] | |
|---|---|
| Systematic Name | LmjF.16.0250 [Leishmania major] |
| Gene Name | LMJF_16_0250 |
| Molecular Weight | 19535 Da |
| Protein Sequence Size | 176 |
| Function | |
| Charge | 4 |
| Isoelectric Point | 7.7 pH |
| Description | Protein tyrosine phosphatase-likie protein. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QEZ5|Q4QEZ5_LEIMA Protein tyrosine phosphatase-likie protein - Leishmania major. DINGTIVDCKRNGTDEVIFRFLILDAPSPSSLPTYVKLLQRQNVHHLVRACGPTYNAELV EKNGIQVHGWTFDDGAPPTRVVIDSWLDLLSLEAGKTPPETIAVHCVAGLGRAPILVALA LVEYGNMAPLDAVGYVRERRKGAINQVQLNWLMRYRPRHHQASDRSLVCTNCVIL |
| DNA Sequence | >LmjF16.0250 |||protein tyrosine phosphatase-likie protein|Leishmania major|chr 16|||Manual ATGGACATCA ACGGCACCAT TGTGGACTGC AAGCGCAACG GCACTGACGA GGTCATTTTCCGCTTCCTCA TCCTTGACGC ACCGAGCCCG AGCAGCCTGC CCACCTACGT GAAGCTCCTGCAGCGGCAAA ATGTGCACCA CCTCGTCCGC GCCTGCGGCC CTACCTACAA CGCCGAGCTGGTGGAAAAGA ACGGCATCCA GGTGCATGGG TGGACCTTCG ACGACGGAGC GCCGCCAACGCGGGTGGTGA TTGACAGTTG GCTCGACCTG CTATCTCTGG AGGCCGGCAA GACGCCGCCGGAGACTATCG CGGTCCATTG CGTGGCGGGT CTGGGACGGG CACCGATCTT GGTTGCACTGGCACTGGTGG AGTACGGCAA CATGGCTCCG CTGGACGCCG TGGGCTATGT TCGAGAGCGGCGGAAGGGTG CCATCAACCA GGTGCAGCTG AACTGGCTCA TGCGATACAG GCCGCGCCATCACCAGGCGA GTGATCGTTC TCTTGTCTGT ACCAACTGCG TCATCCTGTG A |
| Protein tyrosine phosphatase-likie protein Q4QEZ5] | |
|---|---|
| Metabolite Information | |
| Molecular Function | phosphoprotein phosphatase activity |
| Biochemical Pathway | protein amino acid dephosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K01104 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein tyrosine phosphatase type IVA, member 1 [Homo sapiens] | 49 | 1e-33 | 139 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFR028c dual specificity phosphatase | Saccharomyces cerevisiae | 30% | 0.00000009 | 50.4 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00323 | Tyrosine specific protein phosphatases signature and profiles | 13.97 | 85-152 | PS50056 |
| Acylation | N-myristoylation site | 76-81; | PS00008 | |
| Glycosylation | N-glycosylation site | 4-7; 13-16; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 6-9; 72-75; 86-89; 98-101; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 164-166; | PS00005 | |
| Prenylation | Prenyl group binding site (CAAX box) | 173-176; | PS00294 | |
| Protein tyrosine phosphatase-likie protein [Q4QEZ5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1zckC | |
| Percent Identity | 49% | |
| Target Region | 12-163 | |
| Template Region | 9-151 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 64 | Sidechain |
| CYS | 96 | Sidechain |
| ARG | 102 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 71-50-1 | ACETIC ACID | 60.052 | C2 H4 O2 | O=C(O)C | 1zck |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1599306/Q4QEZ5.pdb 2.0 152 = residues | | = | +| Ramachandran plot: 92.2% core 7.0% allow 0.8% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 150) = | | Chi1-chi2 plots: 0 labelled residues (out of 89) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.7 Bad contacts: = 4 | *| Bond len/angle: 5.7 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.07 Covalent: -0.16 Overall: = -0.02 | | = | | M/c bond lengths: 98.5% within limits 1.5% highlighted = | | M/c bond angles: 93.6% within limits 6.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |