| Inosine-5'-monophosphate dehydrogenase [Q4QEB3] | |
|---|---|
| Systematic Name | LmjF.17.0725 [Leishmania major] |
| Gene Name | GMPR |
| Molecular Weight | 58851 Da |
| Protein Sequence Size | 553 |
| Function | |
| Charge | 18 |
| Isoelectric Point | 8.9 pH |
| Description | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 1.1.1.205 |
| Sequence | >tr|Q4QEB3|Q4QEB3_LEIMA Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) - Leishmania major. SPPRHRTPSLLPSALPTPHPGSFSLRLRTSARTVFVVYIRIYTHPINSSALPPLCLSWLE MAALGSLPTLPEGLTYDDVLLIPQRSPVRSRKAVNTSTRLSRNIHLKIPIVASNMDTVCE DKTAVTMAREGGIGILHRFCSIEEQCAMVRKVKRAQSFLIEDPRMILPSATKAEALEELN WSGRKGGVSCLMVVDDLTSRRLCGVLTKSDLTFATGSALVETLMTPVSRMVVSTNTAITL EEAREVMRTKRTKNIPLLGPKGELLYLITRSDILKLTGNLNATLDSRGRLIVGAAIGVKK EDHERAAALVDAGADVLVVDIAHGHSDLCIDMVKALKVNPLTNKVDIIAGNIATAEAAQD LIDAGADGLKIGVGPGSICITRLVAGSGVPQLSSVMDCARVAKKHGVPCIADGGIKTAGD ICKAIAAGADTVMLGNMLAGTDEAPGRVLVKDGKKVKIIRGMAGFGANISKAEREQRLDE DVFHDLVPEGVEGSVPCKGPLAPILKQLVGGLRSGISYCGSHSIADMQQRARFVRMSGAG LRESGSHDISKL |
| DNA Sequence | >LmjF17.0725 |||inosine-5'-monophosphate dehydrogenase|Leishmania major|chr 17|||Manual ATGTCTCCGC CTCGGCACCG CACTCCATCT CTCCTCCCCT CTGCTCTCCC TACCCCACACCCCGGGTCTT TCTCTCTTCG TCTTCGCACA AGCGCGCGTA CAGTCTTCGT TGTGTATATACGTATATACA CACATCCCAT CAACTCCTCC GCTCTTCCAC CTTTGTGCCT CTCTTGGTTGGAAATGGCAG CCCTAGGCAG TCTTCCTACC CTCCCCGAGG GACTCACTTA CGATGACGTCCTACTCATTC CGCAGCGCAG CCCTGTGCGC TCTCGCAAGG CTGTCAACAC AAGCACACGCCTCAGCCGCA ACATTCACCT CAAGATACCC ATCGTCGCCA GCAACATGGA CACCGTGTGCGAGGACAAGA CGGCCGTGAC GATGGCGCGC GAAGGCGGCA TTGGCATCCT GCACCGCTTCTGTAGCATTG AGGAACAGTG CGCGATGGTG CGCAAGGTGA AGCGCGCGCA GTCCTTCCTGATTGAAGACC CGCGCATGAT CCTGCCGTCG GCGACAAAGG CAGAGGCTCT CGAGGAGCTGAACTGGTCTG GCCGCAAAGG CGGTGTCAGC TGCCTGATGG TGGTGGACGA CCTCACCAGCCGCCGCCTGT GCGGGGTGCT CACCAAGAGC GACCTTACCT TTGCCACCGG CTCCGCCCTCGTCGAAACCC TCATGACGCC GGTGAGCCGA ATGGTCGTCT CGACCAACAC CGCCATCACCCTGGAGGAGG CTCGCGAGGT CATGCGCACG AAGCGGACCA AAAACATTCC GCTGCTGGGTCCCAAAGGAG AGCTGCTCTA CCTCATCACT CGGTCAGACA TTTTGAAGCT GACTGGCAACCTCAACGCCA CCCTTGACTC GCGTGGCCGC CTCATTGTCG GCGCCGCCAT CGGGGTGAAGAAAGAGGATC ACGAGCGTGC AGCTGCCCTA GTGGATGCCG GCGCGGACGT GCTCGTCGTGGATATCGCGC ACGGCCACAG CGACCTCTGC ATCGACATGG TGAAGGCACT CAAGGTGAACCCGCTCACCA ACAAGGTCGA CATCATCGCC GGCAACATCG CCACAGCGGA GGCCGCGCAGGACCTCATCG ACGCGGGAGC AGATGGCTTG AAGATTGGTG TGGGTCCGGG CAGCATCTGCATTACGCGTC TCGTGGCCGG CTCCGGCGTG CCGCAACTGT CTTCCGTGAT GGACTGTGCTCGCGTGGCGA AGAAGCATGG TGTGCCGTGC ATCGCCGACG GTGGTATCAA GACAGCCGGGGACATCTGCA AGGCGATTGC GGCGGGCGCT GACACGGTGA TGTTGGGCAA CATGCTGGCGGGCACCGACG AGGCCCCCGG CCGCGTTCTT GTAAAGGATG GCAAGAAGGT GAAGATCATTCGCGGCATGG CTGGCTTTGG CGCGAACATC AGCAAGGCGG AGCGCGAACA GCGCCTGGACGAGGACGTCT TCCATGATCT CGTGCCGGAG GGTGTCGAGG GCAGCGTGCC GTGCAAGGGCCCCCTCGCAC CGATTCTCAA GCAGCTTGTC GGTGGGCTGC GCTCCGGCAT CTCGTACTGCGGCTCCCACA GCATTGCCGA TATGCAGCAG CGCGCAAGGT TTGTGCGCAT GTCCGGTGCTGGTTTGCGGG AGAGCGGCAG CCACGATATC TCGAAGCTGT AA |
| Inosine-5'-monophosphate dehydrogenase Q4QEB3] | |
|---|---|
| Metabolite Information | |
| Molecular Function | IMP dehydrogenase activity; catalytic activity |
| Biochemical Pathway | purine ribonucleotide biosynthesis; |
| Regulatory Pathway | |
| KEGG Pathways | K00088 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | inosine monophosphate dehydrogenase 1 isoform a [Homo sapiens] | 33 | 3e-70 | 263 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| guaB inositol-monophosphate dehydrogenase | Bacillus subtilis | 42% | 1e-101 | 364 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00391 | IMP dehydrogenase / GMP reductase signature | 370-382; | PS00487 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 551-553; | PS00342 | |
| Acylation | N-myristoylation site | 66-71; 187-192; 279-284; 294-299; 351-356; 369-374; 373-378; 414-419; 415-420; 436-441; 467-472; 491-496; 494-499; 511-516; 512-517; 516-521; 541-546; | PS00008 | |
| Amidation | Amidation site | 183-186; 453-456; | PS00009 | |
| Glycosylation | N-glycosylation site | 48-51; 96-99; 181-184; 282-285; 469-472; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 58-61; 70-73; 76-79; 114-117; 118-121; 142-145; 172-175; 208-211; 240-243; 270-273; 395-398; 418-421; 471-474; 524-527; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 25-27; 31-33; 91-93; 98-100; 183-185; 199-201; 200-202; 250-252; 343-345; | PS00005 | |
| Inosine-5'-monophosphate dehydrogenase [Q4QEB3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1vrdB | |
| Percent Identity | 44% | |
| Target Region | 71-538 | |
| Template Region | 1-317 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1769058/Q4QEB3.pdb 2.0 468 = residues | | = | +| Ramachandran plot: 92.3% core 6.4% allow 1.2% gener 0.0% = disall | | = | +| All Ramachandrans: 12 labelled residues (out of 466) = | +| Chi1-chi2 plots: 6 labelled residues (out of 249) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.7 Bad contacts: = 19 | *| Bond len/angle: 15.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.03 Covalent: -0.39 Overall: = -0.13 | | = | | M/c bond lengths: 98.3% within limits 1.7% highlighted = | *| M/c bond angles: 92.1% within limits 7.9% highlighted 4 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |