| Serine/threonine protein phosphatase type 5, putative [Q4QE27] | |
|---|---|
| Systematic Name | LmjF.18.0150 [Leishmania major] |
| Gene Name | LMJF_18_0150 |
| Molecular Weight | 52956 Da |
| Protein Sequence Size | 469 |
| Function | |
| Charge | 2.5 |
| Isoelectric Point | 6.8 pH |
| Description | Serine/threonine protein phosphatase type 5, putative (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4QE27|Q4QE27_LEIMA Serine/threonine protein phosphatase type 5, putative (EC 3.1.3.16) - Leishmania major. EESDRLKQEGNAYFQEKKFQHAVESYSQAIEAHKTPTLLCNRAFAYLKLELPGAALVDAQ EAVEIDPGFVKAYYRKASAHLLLGKFKDAQKEFAAVLKLVPTEKDARQKYDLCEKELKRI RFENAIKSKDCEPVSTTIKLGTIAASYDGPRIENDTITVQFVEAIQEHFRVEKKIDRRDV VFMLLGVLKLFKSYPNFVTVTVPDGEDITVCGDTHGQFYDLLNIFKLNGKPSPTNRYLFN GDFVDRGSYSVENVLTLFAYKLLYPEHVFLSRGNHEGLSMNRVYGFEGEVRAKYSAEVFD LFSEVFNALPTGHIINDEVFVVHGGLYSRDDVTIADLQKPNRFRDIPENGLICESLWADP QPMPGRTPSKRGVDCPSFGPDVTENFLKNNNLKLVVRSHEVKEDGYEVDHNGKCITVFSA PNYCDQMGNKGAFIRFTGGAMKPKYTTFTHVAHPGKRPMQYACGAGLF |
| DNA Sequence | >LmjF18.0150 |||serine/threonine protein phosphatase type 5, putative|Leishmania major|chr 18|||Manual ATGGAGGAGT CCGACCGCCT GAAGCAGGAG GGCAACGCGT ACTTCCAGGA AAAGAAGTTTCAGCACGCGG TAGAGTCGTA CTCGCAGGCC ATTGAGGCGC ACAAGACGCC GACGCTGCTGTGCAACCGCG CCTTTGCCTA CCTGAAGCTG GAGCTGCCTG GAGCGGCACT TGTAGACGCACAAGAGGCGG TCGAGATCGA CCCTGGCTTT GTGAAGGCGT ACTACCGCAA GGCGTCTGCCCACCTGCTGC TTGGCAAGTT TAAGGATGCG CAGAAGGAGT TCGCCGCCGT CCTTAAGCTGGTGCCGACCG AGAAGGATGC CCGACAGAAG TATGACCTGT GCGAAAAGGA GCTCAAGCGCATTCGCTTCG AGAACGCCAT CAAGTCCAAG GACTGCGAGC CGGTATCTAC TACCATCAAGCTCGGTACCA TCGCTGCGTC GTACGATGGG CCACGCATTG AGAACGACAC GATCACGGTGCAGTTCGTGG AGGCGATCCA GGAGCACTTC CGCGTTGAGA AAAAGATAGA CCGCCGCGACGTTGTGTTTA TGCTGCTGGG GGTCTTAAAG CTGTTCAAGT CGTACCCCAA TTTCGTCACAGTCACAGTGC CAGACGGCGA GGACATTACC GTTTGCGGTG ACACGCATGG TCAGTTCTACGACCTGCTCA ACATCTTCAA GCTGAATGGC AAGCCGTCAC CGACAAACCG CTACCTCTTTAACGGCGACT TTGTCGATCG CGGATCCTAC TCGGTGGAAA ACGTGCTTAC CTTGTTCGCGTACAAGCTGC TGTACCCAGA GCACGTCTTC CTCTCCCGCG GCAACCACGA GGGACTCTCGATGAACCGCG TCTACGGTTT TGAGGGAGAG GTGCGGGCCA AGTACTCGGC CGAGGTGTTTGATCTGTTCT CAGAGGTCTT CAATGCCCTC CCGACGGGGC ACATCATCAA CGATGAGGTGTTTGTCGTCC ACGGCGGTCT CTACTCGCGC GACGACGTCA CCATCGCCGA CCTGCAGAAGCCGAATCGGT TCCGAGACAT CCCCGAGAAC GGCCTCATTT GTGAGAGTCT TTGGGCGGACCCACAGCCGA TGCCGGGTCG CACGCCGAGC AAGCGCGGCG TCGACTGCCC ATCTTTCGGCCCTGACGTCA CGGAGAACTT CCTAAAGAAC AATAATTTGA AGCTCGTCGT GCGCTCACACGAGGTGAAAG AGGACGGCTA CGAGGTGGAC CACAACGGCA AGTGCATCAC CGTGTTCAGTGCCCCGAATT ACTGCGACCA GATGGGCAAC AAGGGCGCCT TCATTCGCTT CACGGGCGGTGCGATGAAGC CCAAATACAC CACCTTTACG |
| Serine/threonine protein phosphatase type 5, putative Q4QE27] | |
|---|---|
| Metabolite Information | |
| Molecular Function | hydrolase activity |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K04460 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 5, catalytic subunit [Homo sapiens] | 48 | 1e-131 | 465 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 37% | 4e-54 | 206 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC50005 | TPR repeat profiles | 8.762; 9.027 | 4-37; 70-103 | PS50005 |
| PDOC50005 | TPR repeat profiles | 8.519; 10.136 | 4-37; 61-103 | PS50293 |
| Acylation | N-myristoylation site | 141-146; 273-278; 277-282; 324-329; 428-433; | PS00008 | |
| Amidation | Amidation site | 454-457; | PS00009 | |
| Glycosylation | N-glycosylation site | 154-157; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 75-78; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 102-105; 201-204; 328-331; 333-336; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 4-6; 102-104; 137-139; 234-236; 369-371; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 6-14; | PS00007 | |
| Serine/threonine protein phosphatase type 5, putative [Q4QE27] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1wao4 | |
| Percent Identity | 48% | |
| Target Region | 1-470 | |
| Template Region | 23-466 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 246 | Sidechain |
| ARG | 247 | Sidechain |
| ASN | 275 | Sidechain |
| HIS | 276 | Sidechain |
| ARG | 372 | Sidechain |
| HIS | 400 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 1wao |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/387002/Q4QE27.pdb 2.0 469 = residues | | = | *| Ramachandran plot: 87.1% core 8.0% allow 3.2% gener 1.7% = disall | | = | *| All Ramachandrans: 29 labelled residues (out of 467) = | +| Chi1-chi2 plots: 4 labelled residues (out of 289) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 21 | *| Bond len/angle: 7.8 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.01 Covalent: -0.21 Overall: = -0.07 | | = | *| M/c bond lengths: 98.4% within limits 1.6% highlighted 1 off = graph | | M/c bond angles: 93.5% within limits 6.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |