| Uracil-DNA-glycosylase, putative [Q4QDZ4] | |
|---|---|
| Systematic Name | LmjF.18.0480 [Leishmania major] |
| Gene Name | LMJF_18_0480 |
| Molecular Weight | 22372 Da |
| Protein Sequence Size | 201 |
| Function | |
| Charge | 9 |
| Isoelectric Point | 8.2642 pH |
| Description | Uracil-DNA-glycosylase, putative (EC 3.2.2.3). |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | 3.2.2.-; 3.2.2.3 |
| Sequence | >tr|Q4QDZ4|Q4QDZ4_LEIMA Uracil-DNA-glycosylase, putative (EC 3.2.2.3) - Leishmania major. AKGKVILPPATDIFNAFNSCPFRDLKVVLLGQDPYHDLHQAHGLCFSVLPEVPLPPSLRN IYKELTTDIPGFQAPRHGYLQSWSEQGMLMLNATLTVEAHKANSHSKASGWTAFTDAVIQ HLSQHHPNRLVFLLWGGYAQQKKKLIDASRHIVLESVHPSPLSASRGWFGCHCFSACNEA LQSMGHLPMHWQLPLNASLP |
| DNA Sequence | >LmjF18.0480 |||uracil-DNA-glycosylase, putative|Leishmania major|chr 18|||Manual ATGGCAAAGG GCAAGGTCAT ACTGCCCCCC GCCACGGACA TCTTCAACGC GTTCAACAGCTGTCCATTTC GCGATTTGAA GGTGGTCCTG CTCGGCCAGG ACCCGTACCA CGATCTCCACCAAGCGCATG GGCTCTGCTT CTCCGTCTTG CCCGAAGTTC CGCTTCCGCC GAGCCTTCGTAACATATACA AGGAGCTCAC GACGGACATC CCGGGCTTCC AGGCACCAAG ACACGGTTACCTGCAGAGCT GGTCGGAGCA GGGGATGCTG ATGCTGAACG CGACTCTGAC CGTCGAGGCGCACAAGGCCA ACTCGCACAG CAAAGCCAGT GGCTGGACCG CCTTCACGGA CGCCGTCATCCAGCACCTTT CCCAGCACCA TCCCAACCGG CTCGTGTTTC TGCTCTGGGG TGGCTACGCGCAGCAGAAGA AGAAGCTCAT AGACGCAAGC CGGCACATCG TCCTGGAGAG TGTGCACCCATCACCGTTGA GCGCCAGCCG CGGCTGGTTT GGGTGCCACT GCTTCTCTGC GTGCAACGAGGCGCTGCAGA GCATGGGCCA CCTTCCCATG CATTGGCAAC TGCCATTGAA TGCTTCGCTACCCTGA |
| Uracil-DNA-glycosylase, putative Q4QDZ4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | uracil DNA N-glycosylase activity |
| Biochemical Pathway | DNA repair; base-excision repair |
| Regulatory Pathway | |
| KEGG Pathways | K03648 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | uracil-DNA glycosylase isoform UNG2 [Homo sapiens] | 52 | 8e-52 | 200 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| ung uracil DNA glycosylase | Haemophilus influenzae | 54% | 2e-55 | 209 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00121 | Uracil-DNA glycosylase signature | 27-36; | PS00130 | |
| Acylation | N-myristoylation site | 44-49; | PS00008 | |
| Glycosylation | N-glycosylation site | 93-96; 197-200; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 83-86; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 58-60; | PS00005 | |
| Uracil-DNA-glycosylase, putative [Q4QDZ4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2booA | |
| Percent Identity | 54% | |
| Target Region | 1-201 | |
| Template Region | 17-230 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 34 | Sidechain |
| HIS | 159 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14797-55-8 | NITRATE ION | 62.005 | N O3 | [O-][N+]([O-])=O | 2boo |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2401140/Q4QDZ4.pdb 2.0 201 = residues | | = | +| Ramachandran plot: 90.1% core 9.3% allow 0.6% gener 0.0% = disall | | = | +| All Ramachandrans: 2 labelled residues (out of 199) = | +| Chi1-chi2 plots: 2 labelled residues (out of 117) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.1 Bad contacts: = 0 | *| Bond len/angle: 8.2 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: -0.02 Covalent: -0.26 Overall: = -0.11 | | = | | M/c bond lengths: 97.7% within limits 2.3% highlighted = | | M/c bond angles: 92.4% within limits 7.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |