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Aconitase, putative [Q4QDZ1]
Systematic NameLmjF.18.0510 [Leishmania major]
Gene NameLMJF_18_0510
Molecular Weight97492 Da
Protein Sequence Size896
Function
Charge1
Isoelectric Point6.6285 pH
DescriptionAconitase, putative (EC 4.2.1.3).
Subcellular LocationN.A.[Predict]
E. C. Number 4.2.1.3
Sequence>tr|Q4QDZ1|Q4QDZ1_LEIMA Aconitase, putative (EC 4.2.1.3) - Leishmania major.
FRTGVQLAKKGVSPNPFNAKFLASLQVDGGSAKYYKINEISAKYNNLPFSIRVLLESAVR
NCDEFDVTSKTVESIFDWKDNCTKGIEIPFKPARVVLQDFTGVPCIVDLAAMRDAMKRLG
GDSLRINPQVPVDLVVDHSVQVDCAGVQDAVVQNQSIEMQRNRERFEFLKWGSRAFDNLL
IVPPGSGIVHQVNLEYLARVVFNADGMLYPDSVVGTDSHTTMVNGLGVVGWGVGGIEAEA
GMLGQSLSLVLPQVVGYKFTGKLQEGCTATDLVLTVVRNLRKLGVVGKFVEFYGPGVDAL
SVADRATLANMAPEYGATTGYFPIDNETIEYLKNTNRSAEHVARIESYVKAVGLFRTGNE
QIEYSQHLELDLSTVAPCVAGPKRPQDNVPLTDVSRDFKACMSAKSGFKGFGIPEGEHNK
KVKYTVNGQEATMEHGSVVIAAITSCTNTSNPTVLIAAGLLAQKALEKGLRVPPGIKTSL
SPGSHVVTKYLENAGLQKSLEALGFHTTGYGCMTCIGNSGDIAPEVSKCITDNNFVAAAV
LSGNRNFESRIHPLTAANYLASPPLVVAFALAGRANIDFAKEPIANGVYLRDIWPSNEEI
VAVVNKYVTPDLFKEVYSNITTMNKQWNELQVENGEFYKWDPKSLYIHSPPYFDDMTLDP
PGVKSIENAACLAIFGDSITTDHISPAGNIAKDSPAAKFLMERGVERKDFNTYGSRRGND
EVMVRGTFANTRLGNRLVGDGQTGPYTLYHPTGEKMFIFDAAMNYKAAGVPTVILAGKEY
GSGSSRDWAAKGPFLQGVKAVIAESFERIHRSNLVGMGVIPLQFKEGENAASLGLTGKEC
FSMNFAGELRPRQDIVVKCDNGKTFTTTLRIDTEVEVKYVENGGILNYVLRTKIQ
DNA Sequence>LmjF18.0510 |||aconitase, putative|Leishmania major|chr 18|||Manual
ATGTTCCGCA CTGGCGTGCA GCTGGCCAAG AAGGGCGTTA GCCCAAACCC CTTCAATGCCAAGTTCCTGG CGTCTCTGCA GGTCGACGGC GGCAGCGCCA AGTACTACAA GATCAACGAGATCAGCGCAA AGTACAACAA CCTCCCCTTC TCCATCCGTG TTCTGCTAGA GTCCGCGGTGCGCAACTGCG ATGAGTTCGA TGTGACCTCG AAGACAGTAG AGAGCATCTT TGACTGGAAGGACAACTGCA CGAAGGGAAT CGAGATTCCG TTCAAGCCAG CTCGCGTGGT GCTGCAGGACTTCACCGGCG TACCGTGCAT CGTGGATCTA GCGGCCATGC GTGACGCGAT GAAGCGCCTTGGCGGTGACT CGCTCCGCAT CAACCCACAA GTTCCCGTCG ACCTCGTAGT GGACCACTCCGTACAGGTGG ACTGCGCTGG CGTGCAGGAC GCAGTGGTGC AAAACCAGAG CATTGAGATGCAACGCAACC GTGAGCGCTT CGAGTTCCTC AAGTGGGGCT CGAGGGCGTT CGACAACCTTCTGATTGTCC CGCCTGGCTC GGGCATTGTG CATCAGGTGA ACCTTGAGTA CCTCGCTCGCGTCGTGTTTA ACGCGGACGG GATGCTATAC CCGGACTCTG TTGTCGGAAC CGACTCGCACACGACGATGG TCAATGGCCT GGGCGTTGTG GGCTGGGGTG TTGGTGGCAT CGAAGCCGAAGCCGGCATGC TGGGCCAGTC CCTCTCCCTG GTGCTGCCGC AGGTCGTTGG CTACAAGTTCACTGGCAAGC TGCAGGAGGG CTGCACGGCA ACCGATCTCG TGCTTACTGT CGTGAGGAACCTTCGCAAGC TCGGTGTGGT GGGCAAGTTT GTCGAGTTCT ACGGCCCCGG TGTCGACGCGCTCTCAGTCG CTGACCGTGC CACGTTGGCC AACATGGCTC CCGAGTACGG CGCCACTACTGGCTACTTCC CCATCGACAA CGAGACGATC GAATACCTCA AGAACACGAA CCGCTCTGCCGAGCACGTGG CCCGCATTGA GAGCTACGTC AAGGCTGTCG GGCTCTTCCG AACCGGCAACGAGCAGATCG AGTACTCGCA GCACCTGGAG CTTGACCTCT CCACAGTGGC GCCGTGCGTTGCCGGCCCGA AGCGCCCTCA AGACAACGTG CCCCTGACGG ATGTGTCGAG GGACTTCAAGGCCTGCATGT CGGCCAAGTC TGGCTTCAAG GGCTTTGGCA TCCCGGAGGG GGAGCACAATAAGAAGGTCA AGTACACCGT CAACGGCCAG GAGGCGACGA TGGAGCACGG CAGCGTCGTGATCGCGGCTA TCACCTCCTG CACGAACACC TCGAACCCCA CCGTGCTCAT CGCGGCGGGTTTGTTGGCAC AGAAGGCCCT GGAAAAGGGC TTGAGGGTGC CGCCGGGCAT TAAGACATCTCTCTCGCCGG GCTCGCACGT GGTGACCAAG TACCTCGAGA ACGCCGGCCT GCAGAAGAGCCTCGAGGCCC TCGGCTTCCA CACGACAGGT TACGGCTGCA TGACGTGCAT CGGCAACTCGGGTGATATCG CGCCGGAGGT GTCCAAGTGC ATCACAGACA ACAATTTCGT TGCCGCAGCGGTGCTCTCCG GCAACCGCAA CTTTGAGTCT CGCATTCACC CGCTGACGGC CGCCAACTACTTGGCATCGC CGCCGCTCGT CGTCGCCTTC GCGCTCGCCG GACGCGCGAA TATCGACTTCGCCAAGGAGC CGATCGCGAA CGGCGTGTAC CTGCGCGACA TCTGGCCAAG CAACGAGGAAATTGTGGCGG TGGTGAACAA GTACGTGACG CCGGACCTGT TCAAGGAGGT GTACTCCAACATCACGACCA TGAACAAGCA ATGGAACGAG CTTCAGGTGG AGAATGGCGA GTTCTACAAGTGGGACCCCA AGTCGTTATA CATTCACAGC CCGCCGTACT TCGACGACAT GACCCTCGACCCACCCGGTG TGAAGAGCAT CGAGAACGCC GCCTGCCTTG CCATCTTCGG TGACTCCATCACGACGGACC ACATCTCGCC GGCCGGCAAC ATAGCCAAGG ACTCACCGGC AGCGAAGTTTCTCATGGAGC GTGGGGTGGA GCGGAAAGAC TTCAACACGT ACGGCTCGCG CCGCGGAAACGACGAGGTGA TGGTGCGCGG CACCTTCGCC AACACGCGTC TCGGCAACCG CCTTGTCGGCGATGGTCAGA CGGGCCCGTA TACGTTGTAC CACCCGACCG GCGAGAAGAT GTTCATCTTCGACGCGGCCA TGAATTACAA GGCGGCCGGC GTGCCGACGG TCATTCTGGC TGGTAAGGAGTACGGCAGCG GCTCGTCGCG CGATTGGGCG GCCAAGGGCC CGTTCCTGCA GGGTGTGAAGGCCGTCATCG CGGAGAGCTT CGAGCGCATT CACCGCTCGA ACCTGGTCGG CATGGGCGTCATTCCGCTGC AGTTCAAGGA AGGCGAGAAT GCCGCCTCCC TTGGCCTGAC CGGCAAGGAGTGCTTCTCGA TGAACTTCGC CGGGGAGCTG CGCCCGCGCC AGGACATCGT CGTGAAGTGCGACAACGGCA AGACCTTCAC GACGACGCTG CGCATTGATA CCGAGGTGGA GGTGAAGTACGTTGAAAACG GTGGCATCCT CAACTATGTG CTGCGCACCA AGATCCAGTA A
Aconitase, putative Q4QDZ1]
Metabolite Information
Molecular Function
Biochemical Pathway
Regulatory Pathway
KEGG PathwaysK01680
Orthologs
Homologs GI Percent Identity Evalue Score
Homo sapiensaconitase 1 [Homo sapiens]5701019
DEG Information
DEG Protein DEG Organism Percent Identity Evalue Bit Score
acn aconitate hydrataseMycobacterium tuberculosis H37Rv49%0856
Post Translational Modification
PTM Type PTM Sub Type Score Modification Site Prosite ID
PDOC00423Aconitase family signatures439-455; PS00450
PDOC00423Aconitase family signatures505-518; PS01244
AcylationN-myristoylation site5-10; 147-152; 235-240; 245-250; 267-272; 317-322; 354-359; 413-418; 429-434; 476-481; 496-501; 512-517; 715-720; 727-732; 782-787; 884-889; PS00008
GlycosylationN-glycosylation site82-85; 155-158; 327-330; 337-340; 449-452; 620-623; PS00001
PhosphorylationCasein kinase II phosphorylation site75-78; 269-272; 302-305; 358-361; 597-600; 785-788; 837-840; 874-877; PS00006
PhosphorylationProtein kinase C phosphorylation site32-34; 42-44; 51-53; 69-71; 124-126; 261-263; 336-338; 404-406; 716-718; 785-787; 837-839; 869-871; PS00005
PhosphorylationTyrosine kinase phosphorylation site357-365; PS00007
SulfationTyrosine sulfation site358-372; 873-887; PS00003
Aconitase, putative [Q4QDZ1]
Model Information
Template PDB ID2b3yB
Percent Identity57%
Target Region1-896
Template Region2-888
Domain Information
Domains Start End
Active Site Information
Residue Active Site Number Functional Part
ASP138Sidechain
HIS139Sidechain
HIS191Sidechain
ASP218Sidechain
HIS220Sidechain
GLU315Sidechain
SER785Sidechain
Co-Factor
Metal Description
Fe, SBinds 1 4Fe-4S cluster per subunit
Ligands
CAS number Name Mol. Weight Mol. Formula Smile Notation PDB Reference
71-50-1ACETATE ION59.044C2 H3 O2[O-]C(=O)C2b3y
992-98-3FORMIC ACID46.025C H2 O2O=CO2b3y
8013-25-0GLYCEROL92.094C3 H8 O3 OCC(O)CO2b3y
IRON/SULFUR CLUSTER351.64Fe4 S4[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]452b3y
Mutational Information
Residue Feature Description
Modeled Protein Template Structure
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/79266/Q4QDZ1.pdb 2.0 896 = residues | | = | *| Ramachandran plot: 93.6% core 5.7% allow 0.4% gener 0.3% = disall | | = | +| All Ramachandrans: 15 labelled residues (out of 894) = | +| Chi1-chi2 plots: 4 labelled residues (out of 491) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 6.8 Bad contacts: = 7 | *| Bond len/angle: 5.8 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.08 Covalent: -0.11 Overall: = 0.01 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 93.5% within limits 6.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further.
Overlapped Structure Procheck Summary
LeishBase: Leishmania Structural Database