| Serine/threonine kinase-like protein, putative [Q4QDX7] | |
|---|---|
| Systematic Name | LmjF.18.0640 [Leishmania major] |
| Gene Name | LMJF_18_0640 |
| Molecular Weight | 31059 Da |
| Protein Sequence Size | 271 |
| Function | |
| Charge | 7 |
| Isoelectric Point | 9.1 pH |
| Description | Serine/threonine kinase-like protein, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QDX7|Q4QDX7_LEIMA Serine/threonine kinase-like protein, putative - Leishmania major. DPSVMVGQYTLGKQIGSGNFSKVRLGTDPQGRTWAIKIVDKRRLKKENMEDQMLREVAIM RSLRQQNVVKLQEVLQSSNHYYLVLELVTGGELFDKIVAAKRFDEPTARRYFHQLIAGMY YCHSKGFAHRDLKPENLLLDANGTLKISDFGLSNLQQDVLLQTICGTPNYVAPEVLMERG YNGLSADIWSCGVVLYVMLAGRLPFEDRNMNVLLGKIERGDYQMIRHISDPAKDLVARML TVDPRKRISMEDVINHPWFQIDWNPRLLST |
| DNA Sequence | >LmjF18.0640 |||serine/threonine kinase-like protein, putative|Leishmania major|chr 18|||Manual ATGGACCCAT CTGTCATGGT GGGCCAGTAC ACGCTGGGCA AGCAGATCGG CTCCGGCAACTTCTCGAAGG TGCGACTGGG CACCGATCCG CAAGGCCGCA CATGGGCCAT CAAGATCGTGGACAAGCGCC GCCTAAAGAA GGAGAACATG GAAGACCAGA TGCTCCGCGA AGTCGCCATCATGCGCAGTC TGCGCCAGCA GAACGTGGTG AAACTCCAGG AGGTGCTCCA GTCCTCTAACCATTACTACC TAGTCCTCGA GCTGGTCACA GGCGGCGAGC TGTTTGACAA AATTGTAGCCGCCAAGCGCT TCGACGAGCC CACAGCGCGT CGGTACTTCC ACCAGCTCAT CGCGGGCATGTACTACTGTC ACTCGAAGGG CTTCGCCCAC CGCGACCTGA AGCCGGAGAA CCTGTTGCTCGACGCGAACG GCACACTGAA GATTTCCGAC TTTGGACTCA GCAACCTCCA GCAGGATGTGCTGCTGCAGA CCATCTGCGG CACGCCAAAC TACGTTGCGC CGGAGGTGCT CATGGAGCGCGGCTACAACG GACTCTCGGC GGACATCTGG AGCTGCGGTG TGGTGCTGTA CGTGATGCTGGCAGGACGTC TGCCCTTCGA GGATCGGAAC ATGAACGTTC TTCTTGGCAA GATCGAGCGTGGCGACTATC AAATGATCCG TCACATCAGC GACCCTGCCA AGGACCTCGT CGCGCGCATGCTGACCGTCG ACCCGCGCAA GCGCATCTCA ATGGAGGATG TCATCAACCA CCCTTGGTTCCAGATTGACT GGAATCCGAG GCTACTCTCC ACGTAA |
| Serine/threonine kinase-like protein, putative Q4QDX7] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity |
| Biochemical Pathway | protein amino acid phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K00908 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | BR serine/threonine kinase 1 [Homo sapiens] | 43 | 1e-58 | 223 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YMR001c involved in regulation of DNA replication | Saccharomyces cerevisiae | 34% | 2e-43 | 170 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 220-222; | PS00016 | |
| PDOC00100 | Protein kinases signatures and profile | 16-38; | PS00107 | |
| PDOC00100 | Protein kinases signatures and profile | 128-140; | PS00108 | |
| PDOC00100 | Protein kinases signatures and profile | 51.806 | 10-260 | PS50011 |
| Acylation | N-myristoylation site | 119-124; | PS00008 | |
| Glycosylation | N-glycosylation site | 20-23; 143-146; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 247-250; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 90-93; 250-253; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 63-65; 108-110; 145-147; | PS00005 | |
| Serine/threonine kinase-like protein, putative [Q4QDX7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2eueB | |
| Percent Identity | 43% | |
| Target Region | 1-269 | |
| Template Region | 48-239 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 132 | Sidechain |
| LYS | 134 | Sidechain |
| ASN | 137 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/314128/Q4QDX7.pdb 2.0 269 = residues | | = | +| Ramachandran plot: 93.2% core 4.6% allow 2.1% gener 0.0% = disall | | = | *| All Ramachandrans: 11 labelled residues (out of 267) = | +| Chi1-chi2 plots: 3 labelled residues (out of 180) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.0 Bad contacts: = 10 | *| Bond len/angle: 14.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.04 Covalent: -0.37 Overall: = -0.11 | | = | *| M/c bond lengths: 98.4% within limits 1.6% highlighted 3 off = graph | *| M/c bond angles: 92.5% within limits 7.5% highlighted 4 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |