| UTP-glucose-1-phosphate uridylyltransferase 2, putative [Q4QDU3] | |
|---|---|
| Systematic Name | LmjF.18.0990 [Leishmania major] |
| Gene Name | UGP |
| Molecular Weight | 54536 Da |
| Protein Sequence Size | 494 |
| Function | |
| Charge | -5 |
| Isoelectric Point | 5.6708 pH |
| Description | UTP-glucose-1-phosphate uridylyltransferase 2, putative (EC 2.7.7.9). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.7.9 |
| Sequence | >tr|Q4QDU3|Q4QDU3_LEIMA UTP-glucose-1-phosphate uridylyltransferase 2, putative (EC 2.7.7.9) - Leishmania major. ENDMKSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPVDSLDAL DSLTIECDNAVLQSTVVLKLNGGLGTGMGLCDAKTLLEVKDGKTFLDFTALQVQYLRQHC SEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFDSEVELMQNQVPKILQDTLEPAAWAEN PAYEWAPPGHGDIYTALYGSGKLQELVEQGYRYMFVSNGDNLGATIDKRVLAYMEKEKID FLMEVCRRTESDKKGGHLARQTVYVKGKDGQPDAEKRVLLLRESAQCPKADMESFQDINK YSFFNTNNLWIRLPVLLETMQEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETAMGAAIA MFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAHY KMMNGFEKLVQHGVPSLVECKRVTVKGLVQFGAGNVLTGTVTIENTDSASAFVIPDGAKL NDTTASPQQSTNK |
| DNA Sequence | >LmjF18.0990 |||UTP-glucose-1-phosphate uridylyltransferase 2, putative|Leishmania major|chr 18|||Manual ATGGAAAACG ACATGAAGTC CCTCAGCGCC GCCGCTCAGG CGTGCGTAAA GAAGATGCGCGACGCCAAGG TGAACGAGGC ATGCATTCGC ACCTTCATCG CACAGCACGT CATGGTCAGTAAAGGCGAGA CAGGGTCCAT TCCCGACTCC GCCATCATGC CGGTCGACTC CCTCGATGCCCTGGACAGCC TCACCATTGA GTGCGACAAC GCTGTCCTGC AGAGTACCGT TGTGCTGAAGCTGAACGGCG GCCTCGGCAC CGGCATGGGG CTGTGCGACG CCAAGACGCT GCTCGAGGTCAAGGATGGCA AGACGTTTCT TGACTTTACA GCGCTTCAGG TACAGTACCT TCGCCAGCACTGCAGCGAGC ACCTGCGCTT TATGTTGATG GACAGCTTCA ACACCTCCGC TAGCACCAAGAGCTTTCTGA AGGCGCGCTA CCCGTGGCTG TACCAGGTCT TTGACTCAGA GGTGGAGCTGATGCAGAATC AGGTGCCCAA AATACTGCAG GACACGCTCG AGCCGGCGGC CTGGGCCGAGAACCCGGCGT ACGAGTGGGC GCCGCCGGGG CACGGTGACA TCTACACCGC TCTGTATGGCTCCGGCAAGC TACAGGAACT CGTCGAGCAG GGCTACCGCT ACATGTTCGT CAGCAACGGGGACAACCTCG GCGCCACCAT CGACAAGCGC GTGCTGGCGT ACATGGAGAA AGAGAAGATCGACTTTCTGA TGGAGGTGTG CCGCCGAACG GAGAGCGACA AGAAAGGCGG TCACCTGGCTCGGCAGACGG TGTATGTGAA GGGCAAGGAC GGTCAACCAG ACGCCGAGAA GAGGGTGCTGCTGCTGCGGG AGTCCGCCCA GTGCCCCAAG GCGGACATGG AAAGCTTCCA GGACATCAACAAGTACTCCT TCTTCAACAC GAACAACCTA TGGATCAGGC TCCCGGTGCT CCTGGAGACGATGCAGGAGC ACGGCGGCAC GCTGCCGCTG CCGGTCATCC GAAACGAGAA GACGGTCGATTCATCTAATT CAGCATCACC CAAGGTGTAT CAACTGGAAA CTGCCATGGG TGCCGCGATCGCCATGTTCG AAAGCGCATC GGCCATTGTC GTGCCGCGCA GCCGCTTCGC GCCAGTGAAGACGTGCGCCG ATCTGCTCGC TCTGCGCTCC GACGCCTACG TCGTGACGGA CGACTTCCGGCTCGTCCTGG ACGATCGCTG CCACGGCCAC CCGCCTGTCG TTGACCTCGA CAGCGCGCACTACAAGATGA TGAATGGCTT TGAGAAGCTC GTGCAACACG GCGTGCCATC GCTGGTGGAATGCAAACGCG TGACGGTGAA GGGGCTGGTT CAGTTCGGTG CTGGCAACGT GCTCACAGGCACGGTCACGA TCGAGAACAC GGACAGCGCC TCGGCGTTTG TGATCCCCGA TGGTGCCAAGCTGAACGACA CAACGGCGTC ACCGCAGCAG TCGACCAACA AGTAG |
| UTP-glucose-1-phosphate uridylyltransferase 2, putative Q4QDU3] | |
|---|---|
| Metabolite Information | |
| Molecular Function | nucleotidyltransferase activity |
| Biochemical Pathway | UDP-glucose metabolism; metabolism |
| Regulatory Pathway | |
| KEGG Pathways | K00963 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | UDP-glucose pyrophosphorylase 2 isoform b [Homo sapiens] | 35 | 1e-63 | 241 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YKL035w UTP--glucose-1-phosphate uridylyltransferase | Saccharomyces cerevisiae | 38% | 5e-71 | 262 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 83-88; 84-89; 86-91; 88-93; 90-95; 256-261; 271-276; 357-362; 455-460; 478-483; | PS00008 | |
| Glycosylation | N-glycosylation site | 134-137; 482-485; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 442-445; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 40-43; 46-49; 96-99; 105-108; 156-159; 218-221; 250-253; 295-298; 320-323; 381-384; 437-440; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 138-140; 201-203; 252-254; 346-348; 445-447; 492-494; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 386-400; | PS00003 | |
| UTP-glucose-1-phosphate uridylyltransferase 2, putative [Q4QDU3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2oegA | |
| Percent Identity | 100% | |
| Target Region | 1-494 | |
| Template Region | 7-482 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 58-98-0 | URIDINE-5'-DIPHOSPHATE-GLUCOSE | 566.302 | C15 H24 N2 O17 P2 | O=P(OC1OC(C(O)C(O)C1O)CO)(O)OP(=O)(O)OCC3OC(N2C=CC(=O)NC2=O)C(O)C3O | 2oeg |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/4048308/Q4QDU3.pdb 2.0 494 = residues | | = | *| Ramachandran plot: 93.4% core 5.9% allow 0.5% gener 0.2% = disall | | = | +| All Ramachandrans: 9 labelled residues (out of 492) = | +| Chi1-chi2 plots: 2 labelled residues (out of 285) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | *| Bond len/angle: 7.7 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.12 Covalent: -0.08 Overall: = 0.04 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 95.6% within limits 4.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |