| Nonspecific nucleoside hydrolase [Q4QDN1] | |
|---|---|
| Systematic Name | LmjF.18.1580 [Leishmania major] |
| Gene Name | NH |
| Molecular Weight | 34282 Da |
| Protein Sequence Size | 314 |
| Function | |
| Charge | -2 |
| Isoelectric Point | 6.1767 pH |
| Description | Nonspecific nucleoside hydrolase. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QDN1|Q4QDN1_LEIMA Nonspecific nucleoside hydrolase - Leishmania major. PRKIILDCDPGIDDAVAIFLAHGNPEIELLAITTVVGNQSLEKVTQNARLVADVAGIVGV PVAAGCTKPLVRGVRNASHIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTI TLVPTGGLTNIAMAVRLEPRIVDRVKEVVLMGGGYHTGNASPVAEFNVFIDPEAAHIVFN ESWNVTMVGLDLTHQALATPAVQKRVREVGTKPAAFMLQILDFYTKVYEKEHDTYGKVHD PCAVAYVIDPTVMTTERVPVDIELNGALTTGMTVADFRYPRPKNCRTQVAVKLDFDKFWC LVIDALERIGDPQ |
| DNA Sequence | >LmjF18.1580 |NH||nonspecific nucleoside hydrolase|Leishmania major|chr 18|||Manual ATGCCGCGCA AGATTATTCT CGACTGTGAT CCCGGGATCG ATGATGCCGT GGCCATCTTTCTCGCCCACG GCAACCCGGA GATCGAGCTG CTGGCCATTA CGACGGTGGT GGGCAACCAGAGCCTGGAGA AGGTGACCCA GAACGCGCGG CTGGTAGCTG ACGTAGCTGG CATCGTTGGTGTGCCCGTCG CGGCTGGCTG CACCAAGCCC CTCGTACGCG GTGTGCGGAA TGCCTCTCATATTCACGGCG AAACCGGCAT GGGTAATGTC TCCTACCCAC CAGAGTTCAA GACAAAGTTGGACGGCCGCC ATGCAGTGCA GCTGATCATC GACCTTATCA TGTCGCACGA GCCCAAGACGATCACGCTTG TGCCTACGGG TGGACTGACG AACATTGCGA TGGCTGTCCG TCTTGAGCCGCGCATCGTGG ACCGTGTGAA GGAGGTGGTT CTGATGGGTG GCGGCTACCA TACTGGTAATGCTTCCCCTG TCGCGGAGTT CAACGTCTTC ATCGACCCGG AGGCGGCGCA CATTGTGTTCAACGAGAGCT GGAACGTAAC AATGGTGGGA CTGGACCTGA CGCACCAGGC CCTCGCCACGCCGGCGGTCC AGAAGCGGGT GAGGGAGGTG GGCACGAAGC CGGCTGCCTT CATGCTGCAGATTTTGGACT TTTACACGAA GGTGTACGAA AAGGAGCACG ACACGTACGG GAAGGTGCACGATCCGTGCG CTGTGGCGTA CGTGATTGAC CCCACCGTGA TGACGACGGA GCGAGTGCCTGTGGACATCG AGCTCAATGG GGCACTGACG ACTGGGATGA CGGTCGCGGA CTTCCGCTACCCGCGGCCAA AGAACTGCCG CACGCAGGTG GCTGTGAAGC TGGACTTCGA CAAGTTTTGGTGCCTCGTGA TTGACGCACT CGAGCGCATC GGCGATCCTC AGTGA |
| Nonspecific nucleoside hydrolase Q4QDN1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K10213 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | PREDICTED: hypothetical protein LOC359845 [Homo sapiens] | 37 | 2.7 | 30 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| hpt hypoxanthine phosphoribosyltransferase | Mycoplasma genitalium | 26% | 2.6 | 26.9 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00960 | Inosine-uridine preferring nucleoside hydrolase family signature | 8-18; | PS01247 | |
| Acylation | N-myristoylation site | 12-17; 60-65; 74-79; 127-132; 154-159; 190-195; 211-216; 267-272; 272-277; | PS00008 | |
| Glycosylation | N-glycosylation site | 39-42; 77-80; 89-92; 181-184; 185-188; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 98-101; 274-277; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 256-258; | PS00005 | |
| Nonspecific nucleoside hydrolase [Q4QDN1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1ezrD | |
| Percent Identity | 94% | |
| Target Region | 1-314 | |
| Template Region | 2-312 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 10 | Sidechain |
| ASN | 168 | Sidechain |
| HIS | 240 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 1ezr |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1305720/Q4QDN1.pdb 2.0 314 = residues | | = | | Ramachandran plot: 92.2% core 7.8% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 312) = | +| Chi1-chi2 plots: 1 labelled residues (out of 170) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.2 Bad contacts: = 1 | *| Bond len/angle: 5.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.05 Covalent: -0.13 Overall: = -0.02 | | = | | M/c bond lengths: 98.8% within limits 1.2% highlighted = | | M/c bond angles: 93.7% within limits 6.3% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |