| Histone H3 variant, putative [Q4QDF8] | |
|---|---|
| Systematic Name | LmjF.19.0630 [Leishmania major] |
| Gene Name | LMJF_19_0630 |
| Molecular Weight | 16324 Da |
| Protein Sequence Size | 144 |
| Function | |
| Charge | 22 |
| Isoelectric Point | 11.5081 pH |
| Description | Histone H3 variant, putative. |
| Subcellular Location | nucleosome; nucleus[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QDF8|Q4QDF8_LEIMA Histone H3 variant, putative - Leishmania major. AGITKAAVVASHPKKNVASRKMNKKSRSIAKKEAKAMRADSAGAKSRRWRPGTVALREVR KYQRSTELLIARTPFRRLVKEIMSTFKDTMHMRHSALEAMQDATESYLVSLLCDANLCTI HAKRVTLYPKDLQLALRLRGERT |
| DNA Sequence | >LmjF19.0630 |||histone H3 variant, putative|Leishmania major|chr 19|||Manual ATGGCCGGCA TCACCAAGGC CGCTGTTGTG GCGAGCCACC CGAAGAAGAA TGTGGCCAGCCGCAAGATGA ACAAGAAGAG CCGCTCGATC GCCAAGAAGG AGGCCAAAGC GATGCGCGCCGACTCCGCCG GTGCCAAGAG TCGTCGCTGG CGCCCAGGCA CTGTCGCACT GCGCGAGGTGCGTAAGTACC AGCGCTCGAC GGAGCTGCTC ATCGCGCGTA CCCCGTTCCG CCGCCTCGTGAAGGAGATTA TGTCCACCTT CAAGGACACG ATGCACATGC GCCACTCCGC CCTCGAGGCGATGCAGGATG CGACGGAAAG CTACCTTGTG AGTTTGCTCT GCGACGCGAA TCTGTGCACCATTCATGCCA AACGTGTAAC GCTGTACCCC AAGGACCTGC AGCTAGCATT GCGCCTCCGCGGAGAGCGCA CGTAA |
| Histone H3 variant, putative Q4QDF8] | |
|---|---|
| Metabolite Information | |
| Molecular Function | DNA binding |
| Biochemical Pathway | chromosome organization and biogenesis (sensu Eukaryota); nucleosome assembly |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | hypothetical protein LOC440093 [Homo sapiens] | 54 | 1e-31 | 132 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YKL049c strong similarity to histone H3 | Saccharomyces cerevisiae | 44% | 7e-23 | 100 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00287 | Histone H3 signatures | 75-83; | PS00959 | |
| Acylation | N-myristoylation site | 3-8; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 124-127; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 86-89; 96-99; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 20-22; 47-49; 86-88; | PS00005 | |
| Histone H3 variant, putative [Q4QDF8] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2nzdE | |
| Percent Identity | 55% | |
| Target Region | 47-144 | |
| Template Region | 38-97 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 2nzd |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1287408/Q4QDF8.pdb 2.0 98 = residues | | = | | Ramachandran plot: 98.9% core 1.1% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 96) = | | Chi1-chi2 plots: 0 labelled residues (out of 63) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.1 Bad contacts: = 0 | +| Bond len/angle: 4.1 Morris et al class: 1 = 1 1 | | = | | G-factors Dihedrals: 0.30 Covalent: -0.05 Overall: = 0.17 | | = | | M/c bond lengths: 99.8% within limits 0.2% highlighted = | | M/c bond angles: 95.7% within limits 4.3% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |