| Inosine-5'-monophosphate dehydrogenase [Q4QD53] | |
|---|---|
| Systematic Name | LmjF.19.1560 [Leishmania major] |
| Gene Name | LMJF_19_1560 |
| Molecular Weight | 55547 Da |
| Protein Sequence Size | 514 |
| Function | |
| Charge | 12.5 |
| Isoelectric Point | 8.7944 pH |
| Description | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 1.1.1.205 |
| Sequence | >tr|Q4QD53|Q4QD53_LEIMA Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) - Leishmania major. ATNNANYRIKTIKDGCTAEELFRGDGLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHI PIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPP NTPISNIIRIKEEKGISGILVTENGDPHGKLLGIVCTKDIDYVKNKDTPVSAVMTRREKM TVERAPIQLEEAMDVLNRSRYGYLPIVNENGEVVNLCSRRDAVRARDYPHSTLDKSGRLI CAAATSTRPEDKRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVV TQDQAKNLIDAGADGIRIGMGSGSICITQEVLACGRPQGTAVYKVAQYCASRGVPCTADG GLRQVGDICKALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKE SGKRYLSENEVIQVAQGVSGNVVDKGSAAKLIAYVSKGLQQAAQDIGEISFDAIREKMYA GQVLFNRRSPTAQGEGGVHSLHSYEKKLFAAKM |
| DNA Sequence | >LmjF19.1560 |||inosine-5'-monophosphate dehydrogenase|Leishmania major|chr 19|||Manual ATGGCGACCA ACAACGCGAA CTACCGCATC AAGACCATCA AGGATGGCTG CACCGCCGAGGAGCTGTTCC GGGGCGATGG ACTGACATAC AACGACTTCA TTATTCTGCC GGGCTTCATCGACTTTGGTG CTGCCGATGT GAACATCTCC GGCCAGTTCA CGAAGCGCAT CCGCCTCCACATCCCGATCG TGTCGTCGCC GATGGACACC ATTACGGAGA ACGAGATGGC GAAGACAATGGCACTCATGG GCGGCGTCGG TGTGCTGCAC AACAACTGCA CGGTGGAGCG GCAAGTGGAGATGGTGAAGT CGGTGAAGGC GTACCGCAAC GGATTCATCT CCAAGCCCAA GTCGGTGCCGCCGAACACCC CCATCAGCAA CATCATCCGC ATCAAGGAGG AGAAGGGCAT CAGCGGCATTCTCGTGACGG AGAACGGCGA CCCGCACGGC AAGCTGCTTG GCATCGTGTG CACGAAGGATATCGACTACG TAAAGAACAA GGACACGCCG GTATCGGCGG TTATGACGCG ACGCGAGAAGATGACGGTGG AGCGTGCGCC GATCCAGCTG GAAGAGGCAA TGGACGTGCT GAACCGCAGCCGCTACGGCT ACCTGCCCAT CGTGAACGAG AACGGCGAGG TTGTCAATCT CTGCTCCCGTCGCGATGCTG TCCGCGCGCG TGACTACCCG CACAGCACAC TGGACAAAAG CGGTCGACTCATCTGTGCTG CTGCAACCTC AACGCGCCCG GAGGACAAGC GGCGAGTGGC AGCTCTGGCGGATGTCGGCG TTGATGTTCT GGTTCTGGAC AGCTCTCAGG GCAACACGAT CTACCAGATCGCCTTCATTA AGTGGGTCAA GTCGACCTAT CCGCACCTCG AGGTGGTGGC AGGCAATGTGGTGACGCAAG ATCAGGCAAA GAACCTCATC GATGCCGGCG CGGACGGTAT TCGCATCGGCATGGGCAGCG GCAGCATCTG CATCACGCAG GAGGTTCTAG CTTGCGGTCG TCCTCAGGGTACGGCGGTGT ACAAGGTGGC GCAGTACTGC GCGTCCCGCG GCGTTCCGTG CACTGCTGACGGTGGGCTTC GCCAGGTCGG CGACATCTGC AAGGCGCTTG CCATCGGTGC CAACTGCGCGATGCTTGGCG GCATGTTGAG TGGCACAACT GAGACGCCTG GCGAGTACTT CTTCAAGGGCGGCGTGCGCC TGAAGGTGTA CCGCGGCATG GGTAGCCTGG AGGCGATGAG CCAGGGCAAGGAGTCCGGCA AGCGCTACCT CTCCGAAAAC GAGGTGATAC AGGTTGCACA GGGCGTCTCTGGCAACGTCG TGGATAAGGG TTCTGCCGCG AAGCTAATCG CCTACGTCTC GAAAGGGCTCCAGCAGGCGG CGCAGGACAT CGGCGAGATC AGCTTCGACG CGATTCGCGA GAAGATGTACGCCGGCCAGG TGCTTTTCAA CCGCCGCTCC CCCACGGCCC AGGGCGAGGG TGGCGTGCACTCGCTTCACA GCTACGAGAA GAAGCTGTTT GCAGCCAAGA TGTAG |
| Inosine-5'-monophosphate dehydrogenase Q4QD53] | |
|---|---|
| Metabolite Information | |
| Molecular Function | IMP dehydrogenase activity; catalytic activity |
| Biochemical Pathway | GMP biosynthesis |
| Regulatory Pathway | |
| KEGG Pathways | K00088 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | inosine monophosphate dehydrogenase 1 isoform a [Homo sapiens] | 52 | 1e-149 | 524 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| guaB inositol-monophosphate dehydrogenase | Bacillus subtilis | 33% | 5e-76 | 279 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 24-26 | PS00016 | |
| PDOC00391 | IMP dehydrogenase / GMP reductase signature | 317-329; | PS00487 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 512-514; | PS00342 | |
| Acylation | N-myristoylation site | 27-32; 87-92; 139-144; 154-159; 298-303; 316-321; 320-325; 354-359; 376-381; 383-388; 384-389; 411-416; 438-443; 459-464; 497-502; | PS00008 | |
| Amidation | Amidation site | 422-425; | PS00009 | |
| Glycosylation | N-glycosylation site | 48-51; 92-95; 198-201; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 12-15; 18-21; 29-32; 66-69; 70-73; 72-75; 176-179; 219-222; 232-235; 248-251; 392-395; 428-431; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 12-14; 54-56; 104-106; 176-178; 219-221; 237-239; 247-249; 422-424; | PS00005 | |
| Inosine-5'-monophosphate dehydrogenase [Q4QD53] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1jcnB | |
| Percent Identity | 51% | |
| Target Region | 1-514 | |
| Template Region | 10-395 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE | 367.66 | C10 H13 Cl N4 O7 P | Clc1c2ncn(c2nc[nH+]1)C3OC(C(O)C3O)COP(=O)(O)O | 1jcn | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2125088/Q4QD53.pdb 2.0 514 = residues | | = | *| Ramachandran plot: 90.0% core 8.1% allow 0.9% gener 0.9% = disall | | = | *| All Ramachandrans: 19 labelled residues (out of 512) = | +| Chi1-chi2 plots: 1 labelled residues (out of 283) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.5 Bad contacts: = 11 | *| Bond len/angle: 10.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.01 Covalent: -0.38 Overall: = -0.15 | | = | *| M/c bond lengths: 98.6% within limits 1.4% highlighted 2 off = graph | *| M/c bond angles: 90.3% within limits 9.7% highlighted 3 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |