| Phosphoglucomutase, putative [Q4QCF1] | |
|---|---|
| Systematic Name | LmjF.21.0640 [Leishmania major] |
| Gene Name | LMJF_21_0640 |
| Molecular Weight | 63896 Da |
| Protein Sequence Size | 589 |
| Function | |
| Charge | -4.5 |
| Isoelectric Point | 6 pH |
| Description | Phosphoglucomutase, putative (EC 5.4.2.2). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 5.4.2.2 |
| Sequence | >tr|Q4QCF1|Q4QCF1_LEIMA Phosphoglucomutase, putative (EC 5.4.2.2) - Leishmania major. EVTTTAYKDQKPGTSGLRKKVTVFQQPNYTANFVQSTFNALHRQGAVPDVLVVGGDGRYY TSEAVQVILKVSAANGVRCVWVGQHGLLSTPAVSTMVRRRRDADGRKATGAFILTASHNP GGPDADFGIKYNSENGGPAPEKLTSQIYEETVKITHIKMAPTLPEVDIHTLGTYTFDDYN FQVEVVDSLADYAAYMQEVFDFEAIRALVQRLDFKVHVDSLHGVSGPYVDRIFHEGLGVP KTSLFRTNVLPDFGGCHPDPNLTYAADLVHVMGLLPDGNANPAMKHISTVPSFGVAFDGD ADRNMILGCRFFVNPSDSLAVLAANADCVPFFTQSSSSGLKAVARSMPTSGAVDRVAAAH DFALFEVPTGWKFFGNLMDSKDLYGGKDFNPLLCGEESFGTGSNHIREKDGIWASLFWLS VIAKRNAPGTPLVGVQQIVEEHWATYGRNYYSRYDYEDVSAEAAKAVMDTVENTVVDDVP NLNGVACKTIDNFSYTDPIDGSVSTKQGVRVLFEDGSRFVLRLSGTGSSGATIRLYLEQY MDSATVKSHLAEKTLPTASTALKALIGVALQVSKMESLTGRKTPTVIT |
| DNA Sequence | >LmjF21.0640 |||phosphoglucomutase, putative|Leishmania major|chr 21|||Manual ATGGAGGTGA CAACGACAGC GTACAAGGAC CAGAAGCCGG GCACATCGGG GCTGCGCAAGAAGGTCACAG TGTTTCAGCA GCCGAACTAC ACAGCGAACT TTGTGCAGAG CACCTTCAACGCTCTGCATC GCCAAGGCGC CGTGCCAGAT GTGCTCGTCG TGGGAGGCGA TGGACGCTACTACACTTCCG AGGCGGTGCA GGTGATCCTG AAGGTCTCCG CCGCGAATGG GGTGCGGTGTGTGTGGGTGG GTCAGCACGG GCTTCTCTCG ACGCCGGCCG TTTCAACAAT GGTGCGTCGTCGCCGTGACG CGGACGGGCG CAAGGCGACC GGTGCTTTTA TCTTGACGGC CAGCCACAATCCCGGTGGCC CGGACGCCGA CTTTGGCATC AAGTACAACT CTGAGAACGG CGGCCCGGCCCCAGAGAAGC TGACGTCCCA GATCTACGAG GAGACGGTCA AGATTACGCA CATCAAGATGGCCCCGACGC TGCCGGAGGT GGACATCCAC ACCCTTGGTA CCTACACCTT TGACGACTACAACTTCCAGG TGGAGGTGGT TGACAGCTTG GCTGACTACG CTGCGTACAT GCAGGAGGTGTTCGACTTCG AGGCCATCAG GGCACTCGTG CAGCGCCTCG ACTTCAAGGT CCACGTGGACAGCCTTCACG GCGTCAGCGG CCCATACGTT GACCGCATCT TTCACGAGGG CCTTGGTGTGCCCAAGACCT CCCTATTCCG CACGAACGTC CTGCCCGACT TTGGCGGCTG CCACCCCGATCCGAATCTCA CGTACGCGGC CGACTTGGTG CATGTGATGG GGCTGCTGCC GGACGGCAACGCGAACCCCG CGATGAAGCA CATCAGCACA GTGCCCAGCT TCGGTGTCGC GTTTGATGGGGATGCGGACC GCAACATGAT CCTCGGCTGC CGCTTCTTCG TGAACCCGTC CGACTCACTTGCCGTGCTGG CTGCCAACGC CGACTGCGTG CCCTTCTTCA CCCAAAGCAG TAGCTCCGGGCTCAAGGCCG TGGCGCGGTC GATGCCGACG AGCGGTGCGG TCGACCGCGT CGCTGCGGCACACGACTTCG CGCTCTTCGA GGTCCCTACG GGGTGGAAGT TCTTTGGCAA CCTCATGGACAGCAAGGACC TCTACGGGGG CAAGGACTTC AACCCTCTGC TCTGCGGCGA GGAGAGCTTCGGCACGGGCA GCAATCACAT CCGTGAGAAG GACGGTATCT GGGCGTCGCT CTTCTGGCTGTCGGTGATCG CGAAGCGCAA CGCTCCTGGC ACCCCGCTGG TCGGCGTCCA GCAGATTGTGGAGGAGCACT GGGCGACGTA TGGCCGCAAT TACTACAGCC GATACGACTA CGAGGACGTTTCCGCCGAGG CCGCGAAGGC CGTCATGGAC ACGGTCGAGA ATACAGTGGT GGACGACGTGCCGAATCTCA ACGGAGTCGC GTGCAAGACG ATCGACAACT TCAGCTACAC TGATCCTATCGATGGCTCCG TCTCGACGAA GCAGGGCGTG CGTGTGCTCT TCGAGGACGG GTCGCGCTTCGTGCTGCGGC TGAGCGGCAC CGGCTCCTCT GGCGCCACCA TCCGGCTCTA CCTGGAGCAGTATATGGACT CAGCCACGGT GAAGTCGCAC TTGGCGGAGA AGACGCTGCC AACTGCGAGCACCGCGCTGA AGGCTCTCAT TGGAGTTGCA CTGCAGGTGT CCAAGATGGA ATCTCTGACTGGCCGCAAGA CACCGACGGT GATCACATAA |
| Phosphoglucomutase, putative Q4QCF1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | intramolecular transferase activity, phosphotransferases |
| Biochemical Pathway | carbohydrate metabolism |
| Regulatory Pathway | |
| KEGG Pathways | K01835 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | phosphoglucomutase 1 [Homo sapiens] | 49 | 1e-153 | 537 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| SA2279 hypothetical protein, similar to phosphomannomutase | Staphylococcus aureus | 23% | 0.0000002 | 51.6 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00589 | Phosphoglucomutase and phosphomannomutase phosphoserine signature | 112-121; | PS00710 | |
| Acylation | N-myristoylation site | 122-127; 129-134; 239-244; 401-406; 412-417; 502-507; 526-531; 528-533; | PS00008 | |
| Amidation | Amidation site | 105-108; 580-583; | PS00009 | |
| Glycosylation | N-glycosylation site | 29-32; 262-265; 493-496; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 20-23; 107-110; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 163-166; 176-179; 189-192; 453-456; 475-478; 495-498; 574-577; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 152-154; 505-507; 533-535; 546-548; 580-582; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 489-496; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 173-187; 448-462; 450-464; 489-503; | PS00003 | |
| Phosphoglucomutase, putative [Q4QCF1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 3pmgB | |
| Percent Identity | 49% | |
| Target Region | 1-604 | |
| Template Region | 1-560 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 3pmg |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2284440/Q4QCF1.pdb 2.0 589 = residues | | = | +| Ramachandran plot: 89.2% core 10.4% allow 0.4% gener 0.0% = disall | | = | +| All Ramachandrans: 14 labelled residues (out of 587) = | +| Chi1-chi2 plots: 5 labelled residues (out of 306) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.1 Bad contacts: = 13 | *| Bond len/angle: 12.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.02 Covalent: -0.28 Overall: = -0.11 | | = | *| M/c bond lengths: 98.9% within limits 1.1% highlighted 2 off = graph | *| M/c bond angles: 92.3% within limits 7.7% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |