| Methionine aminopeptidase 2, putative [Q4QCC5] | |
|---|---|
| Systematic Name | LmjF.21.0840 [Leishmania major] |
| Gene Name | LMJF_21_0840 |
| Molecular Weight | 51231 Da |
| Protein Sequence Size | 465 |
| Function | |
| Charge | 4.5 |
| Isoelectric Point | 6.9978 pH |
| Description | Methionine aminopeptidase 2, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.4.11.18 |
| Sequence | >tr|Q4QCC5|Q4QCC5_LEIMA Methionine aminopeptidase 2, putative - Leishmania major. PPKISAKSKQQPKQQGGNKKGKGSNDDGDDFDAMLAAAVNASKADAAKNHSNNHQGKRSS NGYGAAPVSRSLAADEPVVPSSANHPENPYPKTADGYPRQTWPEPTVPVSKQFAAGQFPA GEIVDHPGEMNNFRRSSEEKRALARASEQQVQEMREAAEVHRQVRTWAQSWIKPGLSLML MTDRIEKKLNELIGKDGILRGQAFPTGCSLNHVAAHYTPNTGDEKVVLTYDDVMKVDFGT HINGRIIDCAWTVAFNPMFDPLLQAVKEATYEGIKQAGIDVRLGDIGAAIEEVMESHEVE INGKVHQVKSIRNLSGHNIAPYIIHSGKSVPIVKGGEQAKMEEGEVFAIETFGSTGRGFV NEDLECSHYMMQPGAEVMQLRSEKAQQLLKHIHKSYSTLAFCRKWLDRDGFDRHLMNLNR LVDEGAVNKYPPLVDVKGSFTAQYEHTIYLGPTAKEILSKGSDY |
| DNA Sequence | >LmjF23.1650 |||hypothetical protein|Leishmania major|chr 23|||Manual ATGCCGTCGT GGGTGTGCCT AGAGTGCGAG TACGGGAACG AAGAGGGAGA TACGGCCTGCGCAGCATGCG AGGCGGACCG CCCTACTGCA TGTCAGGCCG TCGCCGCGGC GGATGACGATGACGCATACG CGCACATTCA CGTTGGTGTA GTCGTGGAGT GCGAAGATGC GCCCAACACGAAACTGAAGC GCCTGAAGGT TAACGTGGGC CAGGGAGAGC CGATACCCGT TGTGACGGCGGCAACCAATG TGAAACAGGG TGACCACGTC GTCGTGGCCT GCGTCGGGGC CGAGGTCAAGGGCGAGACAG TAACCAAAAC CACAGTCAAG GGGTTCCCTT CGCAGGGGAT GCTGTGCGACGCGGGCATGC TGGGGTGGGT CGGCGGTGGC GCAGGTGCGG CTGTGACGTT GCCGGAGTCCTTTGCTGCGG GTGCGCGTCC GCCGAGCAGC CGCCCGCGCG GTAACGCTGC GTGA |
| Methionine aminopeptidase 2, putative Q4QCC5] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01265 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | methionyl aminopeptidase 2 [Homo sapiens] | 56 | 1e-118 | 423 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| map Methionine aminopeptidase | Streptococcus pneumoniae | 25% | 7e-16 | 79.3 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00575 | Methionine aminopeptidase signatures | 233-249; | PS01202 | |
| Acylation | N-myristoylation site | 18-23; 117-122; 198-203; 208-213; 240-245; 274-279; 336-341; 439-444; | PS00008 | |
| Amidation | Amidation site | 56-59; | PS00009 | |
| Glycosylation | N-glycosylation site | 41-44; 50-53; 314-317; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 58-61; 135-138; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 25-28; 43-46; 102-105; 137-140; 222-225; 230-233; 454-457; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 6-8; 183-185; 311-313; 327-329; 356-358; 383-385; 454-456; | PS00005 | |
| Methionine aminopeptidase 2, putative [Q4QCC5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1b6aA | |
| Percent Identity | 56% | |
| Target Region | 100-465 | |
| Template Region | 110-355 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 230 | Sidechain |
| GLU | 252 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Cobalt | Binds 2 cobalt ions per subunit |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 22541-53-3 | COBALT (II) ION | 58.933 | Co | [Co+2] | 1b6a |
| CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)- 5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL- 2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6- YL ESTER | 401.882 | C19 H28 Cl N O6 | ClCC(=O)NC(=O)OC3CCC1(OC1)C(C2(OC2C/C=C(/C)C)C)C3OC | 1b6a | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1782050/Q4QCC5.pdb 2.0 366 = residues | | = | +| Ramachandran plot: 93.4% core 5.7% allow 0.9% gener 0.0% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 364) = | | Chi1-chi2 plots: 0 labelled residues (out of 224) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.6 Bad contacts: = 3 | *| Bond len/angle: 9.8 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.08 Covalent: -0.24 Overall: = -0.04 | | = | *| M/c bond lengths: 98.2% within limits 1.8% highlighted 2 off = graph | *| M/c bond angles: 93.3% within limits 6.7% highlighted 2 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |