| Cell division protein kinase 2 [Q4QC88] | |
|---|---|
| Systematic Name | LmjF.21.1080 [Leishmania major] |
| Gene Name | CRK1 |
| Molecular Weight | 34461 Da |
| Protein Sequence Size | 301 |
| Function | |
| Charge | 0.5 |
| Isoelectric Point | 6.6292 pH |
| Description | Cell division protein kinase 2 (Cdc2-related kinase) (EC 2.7.1.-). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.1.- |
| Sequence | >tr|Q4QC88|Q4QC88_LEIMA Cell division protein kinase 2 (Cdc2-related kinase) (EC 2.7.1.-) - Leishmania major. TSRYERQEKIGEGTYGVVYKARDTSTSATVALKRIRLDSEEEGVPCTAIREISLLKELRH ENIVKLLDVCHSEHRLTIVFEYLDLDLKKYLDRENGNLDAATIQHFMRDLLRGVAFCHQR SVLHRDLKPQNLLISREKELKLGDFGLGRSFAIPVRKFTNEVVTLWYRPPDVLLGSMQYG PPVDVWSVGCIFSEMATGTPLFAGKNDADQLMRIFRFLGTPNNRVWPSMNQYPNSNNMLS QPEFLQNFEPEWSNVLGSVPGYEKLGCAGVDLLEKLLRYEPSERITAADALNHPYFSLQF |
| DNA Sequence | >LmjF21.1080 |CRK1||cell division protein kinase 2|Leishmania major|chr 21|||Manual ATGACCAGCC GGTACGAGCG GCAGGAGAAG ATCGGCGAGG GCACCTACGG CGTGGTGTACAAGGCCCGAG ACACGTCCAC TTCCGCGACG GTCGCGTTGA AGCGCATTCG GCTTGACTCGGAGGAGGAGG GCGTGCCGTG TACCGCCATT CGCGAGATTT CGCTGCTGAA GGAGCTGCGACATGAGAACA TCGTGAAGCT GCTGGACGTG TGCCACAGCG AGCACCGTCT GACGATCGTCTTCGAGTATT TAGACCTAGA CTTGAAGAAG TATCTCGACC GCGAGAACGG CAACCTCGATGCGGCGACAA TTCAGCACTT TATGCGCGAC CTGCTGCGCG GCGTCGCCTT CTGCCACCAGCGCAGTGTCC TGCATCGCGA CCTGAAGCCG CAGAATCTTC TCATCTCGCG CGAGAAAGAGCTGAAGCTAG GCGACTTCGG TCTCGGTCGT TCCTTCGCCA TCCCAGTGCG CAAATTCACGAACGAGGTGG TGACGCTGTG GTACCGACCG CCCGACGTTC TGCTCGGCTC GATGCAGTACGGTCCGCCGG TGGACGTGTG GTCTGTGGGG TGCATCTTCT CCGAGATGGC CACCGGGACGCCGCTCTTCG CCGGGAAGAA CGATGCCGAC CAGCTCATGC GGATCTTCCG CTTCCTAGGCACACCGAACA ACCGGGTTTG GCCCTCCATG AACCAGTACC CGAACTCGAA CAACATGCTGTCGCAGCCGG AGTTTTTGCA GAACTTCGAG CCGGAATGGA GCAACGTGCT CGGCTCCGTGCCTGGGTACG AGAAGCTTGG TTGTGCTGGT GTCGATCTGC TAGAAAAGTT GCTACGCTACGAGCCGTCGG AGCGCATTAC GGCGGCAGAC GCGTTGAATC ACCCGTACTT TAGCCTCCAGTTTTAG |
| Cell division protein kinase 2 Q4QC88] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity |
| Biochemical Pathway | cell cycle; protein amino acid phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K02090 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | cyclin-dependent kinase 5 [Homo sapiens] | 53 | 1e-83 | 306 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YBR160w cyclin-dependent protein kinase | Saccharomyces cerevisiae | 50% | 5e-79 | 288 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00100 | Protein kinases signatures and profile | 11-34; | PS00107 | |
| PDOC00100 | Protein kinases signatures and profile | 123-135; | PS00108 | |
| PDOC00100 | Protein kinases signatures and profile | 46.336 | 5-297 | PS50011 |
| Acylation | N-myristoylation site | 44-49; 97-102; 114-119; 147-152; 190-195; 220-225; 258-263; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 157-160; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 3-6; 40-43; 241-244; 287-290; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 2-4; 283-285; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 10-16; | PS00007 | |
| Cell division protein kinase 2 [Q4QC88] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1v0oB | |
| Percent Identity | 54% | |
| Target Region | 1-301 | |
| Template Region | 3-275 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 127 | Sidechain |
| LYS | 129 | Sidechain |
| THR | 165 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE- 5'-SULFONIC ACID | 342.326 | C16 H10 N2 O5 S | O=S(=O)(O)c1cc\2c(cc1)NC(=O)C/2=C4\C(=O)c3ccccc3N4 | 1v0o | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/90560/Q4QC88.pdb 2.0 301 = residues | | = | *| Ramachandran plot: 89.0% core 10.2% allow 0.4% gener 0.4% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 299) = | +| Chi1-chi2 plots: 2 labelled residues (out of 193) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 5 | *| Bond len/angle: 5.5 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.06 Covalent: -0.16 Overall: = -0.02 | | = | | M/c bond lengths: 98.9% within limits 1.1% highlighted = | | M/c bond angles: 92.9% within limits 7.1% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |