| Adenylate kinase, putative [Q4QC71] | |
|---|---|
| Systematic Name | LmjF.21.1250 [Leishmania major] |
| Gene Name | LMJF_21_1250 |
| Molecular Weight | 30060 Da |
| Protein Sequence Size | 269 |
| Function | |
| Charge | -2.5 |
| Isoelectric Point | 6 pH |
| Description | Adenylate kinase, putative (EC 2.7.4.3). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.4.3 |
| Sequence | >tr|Q4QC71|Q4QC71_LEIMA Adenylate kinase, putative (EC 2.7.4.3) - Leishmania major. SSNDGLSEDTVMYIKDNNIGQLMEYILRCIITDKPTKPLEYVHELTASPLPPRVVLAGPP ASGKGTQARHICSYYKRAIGKKPVHVSSGDLLRAEVAQGTHLGKIAENFMQRGELVPDSL IISIIRNRLTQEDAVMNGWLLDGFPRTRSQAIALDAAGLCPRIFVVLDTPDDVLFGRVEG RRTDPVTGIIYHLKYNPPPENDTALLERLQHRDDDTREVLGPRLETYHSMVEGLLDYYGS IMYHVDGNRPEAAITKDITEYLQNHNVA |
| DNA Sequence | >LmjF21.1250 |||adenylate kinase, putative|Leishmania major|chr 21|||Manual ATGTCCTCCA ACGACGGCCT CTCCGAGGAC ACGGTCATGT ACATCAAGGA CAACAACATTGGGCAGCTGA TGGAGTACAT CTTGCGTTGC ATCATCACCG ACAAACCAAC CAAGCCGCTCGAATATGTGC ATGAGTTGAC AGCCTCGCCG CTGCCGCCGC GGGTGGTCCT CGCTGGGCCGCCGGCAAGCG GCAAGGGCAC GCAGGCGCGC CACATCTGCT CCTATTACAA GCGCGCGATTGGCAAGAAGC CAGTGCATGT CTCATCGGGC GATCTTCTTC GCGCTGAAGT GGCTCAGGGCACCCACCTGG GCAAGATTGC CGAGAACTTC ATGCAGCGCG GTGAGCTCGT GCCGGATAGCCTCATCATCA GCATTATCCG CAACCGACTG ACGCAGGAGG ACGCGGTGAT GAACGGATGGCTGCTGGACG GCTTCCCGCG CACCCGCTCT CAAGCGATTG CGCTGGACGC CGCAGGCCTGTGCCCCCGCA TCTTTGTGGT CCTCGACACC CCAGATGATG TTTTGTTTGG CCGCGTCGAAGGCCGTCGCA CCGACCCGGT CACCGGCATC ATCTACCACC TCAAGTACAA CCCGCCGCCGGAGAACGACA CGGCGCTGCT CGAGCGGCTG CAGCACCGCG ACGATGACAC CCGCGAGGTGCTTGGCCCTC GTCTGGAGAC ATACCACTCA ATGGTCGAGG GTCTGCTGGA CTACTACGGGTCCATCATGT ATCACGTCGA CGGGAACCGA CCGGAGGCAG CCATCACGAA GGACATTACCGAGTACCTCC AAAACCACAA TGTAGCGTAG |
| Adenylate kinase, putative Q4QC71] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; adenylate kinase activity; nucleotide kinase activity; phosphotransferase activity, phosphate group as acceptor |
| Biochemical Pathway | biological process unknown; nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| Regulatory Pathway | |
| KEGG Pathways | K00939 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | hypothetical protein LOC158067 [Homo sapiens] | 29 | 7e-31 | 131 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| adk Adenylate kinase (EC 2.7.4.3) | Escherichia coli MG1655 | 40% | 4e-38 | 152 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00104 | Adenylate kinase signature | 140-151; | PS00113 | |
| Acylation | N-myristoylation site | 100-105; | PS00008 | |
| Amidation | Amidation site | 80-83; 180-183; | PS00009 | |
| Glycosylation | N-glycosylation site | 202-205; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 2-5; 88-91; 131-134; 170-173; 230-233; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 33-35; 63-65; | PS00005 | |
| Adenylate kinase, putative [Q4QC71] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1zakB | |
| Percent Identity | 48% | |
| Target Region | 50-269 | |
| Template Region | 3-220 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 16 | Sidechain |
| ARG | 133 | Sidechain |
| ARG | 164 | Sidechain |
| ASP | 166 | Sidechain |
| ASP | 167 | Sidechain |
| ARG | 175 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| BIS(ADENOSINE)-5'-PENTAPHOSPHATE | 916.367 | C20 H29 N10 O22 P5 | c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)n5cnc6c5ncnc6N)O)O)O)O)N | 1zak | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1227850/Q4QC71.pdb 2.0 220 = residues | | = | +| Ramachandran plot: 91.9% core 7.6% allow 0.5% gener 0.0% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 218) = | +| Chi1-chi2 plots: 2 labelled residues (out of 131) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.9 Bad contacts: = 1 | *| Bond len/angle: 9.3 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.08 Covalent: -0.09 Overall: = 0.01 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | *| M/c bond angles: 96.1% within limits 3.9% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |