| Calcineurin B subunit, putative [Q4QC21] | |
|---|---|
| Systematic Name | LmjF.21.1630 [Leishmania major] |
| Gene Name | LMJF_21_1630 |
| Molecular Weight | 19660 Da |
| Protein Sequence Size | 175 |
| Function | |
| Charge | -8.5 |
| Isoelectric Point | 4.3769 pH |
| Description | Calcineurin B subunit, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QC21|Q4QC21_LEIMA Calcineurin B subunit, putative - Leishmania major NEIPLTAEELQNIRESTALTDAQVQRLYKSFSKLNKDKSGKITRAEFNSIPALASNPLVD RVLAVMDTDGDSTVDFGDFVRALAVLSSATSKEDKLRFTFKMYDVDGDGRISNKDLFQML SIMVGVNLSQMQLQQIVDKTFIEADVDRDGYITFEEFQALAVNSDFGDRLNLHF |
| DNA Sequence | >LmjF21.1630 |||calcineurin B subunit, putative|Leishmania major|chr 21|||Manual ATGAACGAGA TTCCACTCAC AGCGGAGGAG CTGCAGAACA TCCGCGAGTC CACGGCGCTCACGGACGCGC AAGTGCAGCG GCTGTACAAG AGCTTTTCCA AGCTGAACAA GGACAAGTCTGGCAAGATCA CTCGGGCGGA GTTCAACTCG ATCCCTGCAC TAGCCTCCAA CCCACTCGTCGACAGAGTGC TGGCGGTGAT GGACACGGAC GGCGACTCCA CAGTAGACTT TGGGGACTTTGTGCGGGCAC TGGCGGTGCT CTCCTCGGCG ACCTCGAAGG AGGATAAGTT GCGGTTCACGTTCAAGATGT ACGACGTCGA CGGTGATGGC CGCATAAGCA ACAAGGACCT CTTTCAAATGCTCAGCATCA TGGTTGGGGT GAACCTCTCC CAGATGCAGC TGCAGCAGAT TGTGGACAAGACATTCATCG AAGCGGACGT TGATCGGGAC GGCTACATTA CGTTTGAGGA GTTTCAGGCGCTGGCCGTAA ACAGCGACTT TGGCGATCGG CTGAACCTGC ATTTTTAG |
| Calcineurin B subunit, putative Q4QC21] | |
|---|---|
| Metabolite Information | |
| Molecular Function | calcium ion binding |
| Biochemical Pathway | biological process unknown |
| Regulatory Pathway | |
| KEGG Pathways | K06268 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 3, regulatory subunit B, alpha isoform 1 [Homo sapiens] | 50 | 3e-36 | 147 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YDR373w regulator of phosphatidylinositol-4-OH kinase protein | Saccharomyces cerevisiae | 27% | 0.0000000000001 | 69.7 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 105-117; 146-158; | PS00018 | |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 9.855; 9.018; 13.816; 12.589 | 23-58; 60-90; 92-127; 133-168 | PS50222 |
| Acylation | N-myristoylation site | 126-131; | PS00008 | |
| Glycosylation | N-glycosylation site | 128-131; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 7-10; 44-47; 69-72; 73-76; 91-94; 92-95; 113-116; 141-144; 154-157; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 40-42; 91-93; 100-102; 113-115; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 145-159; | PS00003 | |
| Calcineurin B subunit, putative [Q4QC21] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2p6bD | |
| Percent Identity | 50% | |
| Target Region | 21-175 | |
| Template Region | 15-153 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 2p6b |
| FE (III) ION | 55.845 | Fe | [Fe+3] | 2p6b | |
| 14265-44-2 | PHOSPHATE ION | 94.971 | O4 P | [O-]P([O-])([O-])=O | 2p6b |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 2p6b |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/927416/Q4QC21.pdb 2.0 155 = residues | | = | | Ramachandran plot: 91.6% core 8.4% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 153) = | | Chi1-chi2 plots: 0 labelled residues (out of 100) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.5 Bad contacts: = 3 | +| Bond len/angle: 4.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.23 Covalent: -0.03 Overall: = 0.13 | | = | | M/c bond lengths:100.0% within limits 0.0% highlighted = | | M/c bond angles: 96.2% within limits 3.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |