| Proteasome alpha 2 subunit, putative [Q4QC13] | |
|---|---|
| Systematic Name | LmjF.21.1700 [Leishmania major] |
| Gene Name | LMJF_21_1700 |
| Molecular Weight | 25097 Da |
| Protein Sequence Size | 231 |
| Function | |
| Charge | -1.5 |
| Isoelectric Point | 5.7399 pH |
| Description | Proteasome alpha 2 subunit, putative (EC 3.4.25.1). |
| Subcellular Location | proteasome core complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4QC13|Q4QC13_LEIMA Proteasome alpha 2 subunit, putative (EC 3.4.25.1) - Leishmania major SEAFYGLTTFSPSGKLVQIEYATTAAGKGTTALGVKATDGVVIAAKKKAPSTLVDASSIQ KVFILDEHVGCTYSGMGPDCRVLIDSARKNCQQYRLMYNEPIPISQLVRKISALYQEFTQ SGGVRPFGCSLLVAGVDANGYHLYQVDPSGTFWAWKATAIGTGSPDAKAFLEKRYTVDME LEDAVHTALLTLKEGFDGQMTSENTQVGRVVGNRFEVLSVDQLRDYLDQI |
| DNA Sequence | >LmjF21.1700 |||proteasome alpha 2 subunit, putative|Leishmania major|chr 21|||Manual ATGTCTGAGG CATTTTATGG TCTGACAACG TTTAGCCCTT CAGGAAAGCT GGTCCAGATTGAGTATGCGA CGACAGCTGC CGGAAAAGGG ACGACTGCGC TGGGGGTGAA GGCCACCGATGGGGTCGTCA TTGCTGCGAA GAAGAAGGCT CCATCTACCC TCGTGGATGC CTCATCAATCCAGAAGGTCT TCATCTTGGA TGAGCACGTT GGCTGCACCT ACAGCGGCAT GGGCCCAGACTGCCGTGTTC TTATCGACTC AGCTCGGAAG AACTGCCAGC AGTACAGGCT GATGTACAACGAGCCCATTC CGATCAGCCA GCTGGTGCGG AAGATCAGCG CTCTCTATCA GGAATTCACGCAGTCTGGTG GCGTCCGTCC CTTTGGATGT TCTCTTCTGG TCGCTGGGGT GGATGCTAACGGCTACCATT TGTATCAGGT GGACCCTAGC GGCACGTTCT GGGCGTGGAA GGCGACGGCGATCGGCACCG GAAGTCCGGA CGCGAAGGCA TTTCTAGAAA AGCGTTACAC TGTGGACATGGAGCTGGAGG ATGCTGTGCA CACCGCATTG TTGACGCTAA AGGAGGGCTT TGATGGCCAGATGACGTCAG AAAACACTCA GGTCGGCCGT GTTGTAGGAA ACCGTTTCGA AGTCCTGAGCGTCGATCAGC TGCGGGATTA CCTGGACCAG ATTTAG |
| Proteasome alpha 2 subunit, putative Q4QC13] | |
|---|---|
| Metabolite Information | |
| Molecular Function | threonine endopeptidase activity |
| Biochemical Pathway | ubiquitin-dependent protein catabolism |
| Regulatory Pathway | |
| KEGG Pathways | K02726 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome alpha 2 subunit [Homo sapiens] | 52 | 2e-62 | 235 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YML092c 20S proteasome subunit Y7(alpha2) | Saccharomyces cerevisiae | 44% | 3e-52 | 198 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00326 | Proteasome A-type subunits signature | 4-26; | PS00388 | |
| Acylation | N-myristoylation site | 35-40; 41-46; 71-76; 136-141; 151-156; 164-169; 199-204; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 110-113; 174-177; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 53-56; 192-195; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 14-16; 87-89; 192-194; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 169-176; | PS00007 | |
| Proteasome alpha 2 subunit, putative [Q4QC13] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruP | |
| Percent Identity | 52% | |
| Target Region | 1-231 | |
| Template Region | 1-233 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
|
|
|
| Modeled Protein | Template Structure |
|
|
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/250912/Q4QC13.pdb 2.0 231 = residues | | = | *| Ramachandran plot: 90.5% core 8.0% allow 0.5% gener 1.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 229) = | +| Chi1-chi2 plots: 1 labelled residues (out of 123) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | *| Bond len/angle: 5.8 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.01 Covalent: -0.18 Overall: = -0.06 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | | M/c bond angles: 91.9% within limits 8.1% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |