| Proteasome subunit alpha type [Q4QC00] | |
|---|---|
| Systematic Name | LmjF.21.1830 [Leishmania major] |
| Gene Name | LMJF_21_1830 |
| Molecular Weight | 26784 Da |
| Protein Sequence Size | 244 |
| Function | |
| Charge | -5 |
| Isoelectric Point | 5.1777 pH |
| Description | Proteasome subunit alpha type. |
| Subcellular Location | cytosol; nucleus; proteasome core complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4QC00|Q4QC00_LEIMA Proteasome subunit alpha type - Leishmania major FTSKSEYDRGVNTFSPEGRIFQIEYAVEAIKLGSTSLGIRTPKGVVLAAEKRVPSTLVVP SSMSKIMEIDSHIAAVMSGMVADARILVEHARVESQNHRFTYNEPMSVESCTLATCDLSI QFGESGGKRKLMSRPFGVSLLIAGVDEKGPQLWQTDPSGTHTRYDAQAIGGGAEAAQSVF TERYHRNMTLEEGETLAVDILKQVMEDQLSPENIEVAVVRADDGKLHMYTPTEIKAIMSR MPE |
| DNA Sequence | >LmjF21.1830 |||proteasome alpha 5 subunit, putative|Leishmania major|chr 21|||Manual ATGTTCACCT CCAAGTCTGA GTACGACCGC GGCGTGAACA CCTTCAGCCC GGAAGGTCGCATTTTCCAGA TCGAGTATGC TGTGGAGGCC ATCAAACTGG GTAGTACCAG CCTCGGAATCCGCACGCCTA AGGGCGTCGT TCTTGCCGCG GAGAAACGCG TGCCATCGAC CTTGGTCGTTCCGTCCAGCA TGAGTAAGAT TATGGAGATC GACAGCCACA TTGCGGCTGT CATGAGCGGCATGGTTGCAG ATGCGCGCAT CCTTGTCGAG CACGCCCGCG TGGAGTCGCA GAACCACCGCTTCACCTACA ACGAGCCCAT GTCTGTGGAG TCCTGCACGC TAGCGACGTG CGACCTGTCGATCCAGTTTG GTGAGAGCGG TGGAAAGCGC AAGCTCATGT CGCGCCCGTT CGGCGTTTCGTTGCTCATCG CCGGCGTAGA TGAAAAGGGC CCGCAGCTGT GGCAGACAGA CCCCAGCGGCACGCACACGC GCTACGACGC CCAAGCCATT GGTGGCGGTG CCGAGGCGGC GCAGAGTGTCTTCACGGAGC GCTACCACCG AAACATGACA CTGGAAGAGG GCGAGACGCT CGCGGTGGACATTCTGAAGC AGGTGATGGA GGACCAGCTG TCGCCGGAGA ACATAGAGGT GGCCGTAGTGCGGGCCGACG ACGGCAAGCT GCACATGTAC ACACCCACAG AAATCAAAGC AATCATGAGTCGCATGCCGG AGTAA |
| Proteasome subunit alpha type Q4QC00] | |
|---|---|
| Metabolite Information | |
| Molecular Function | threonine endopeptidase activity |
| Biochemical Pathway | ubiquitin-dependent protein catabolism |
| Regulatory Pathway | |
| KEGG Pathways | K02729 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome alpha 5 subunit [Homo sapiens] | 54 | 7e-70 | 260 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YGR253c 20S proteasome subunit (alpha5) | Saccharomyces cerevisiae | 49% | 5e-60 | 224 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00326 | Proteasome A-type subunits signature | 8-30; | PS00388 | |
| Acylation | N-myristoylation site | 45-50; 172-177; 173-178; | PS00008 | |
| Amidation | Amidation site | 127-130; | PS00009 | |
| Glycosylation | N-glycosylation site | 188-191; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 4-7; 6-9; 102-105; 163-166; 190-193; 231-234; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 3-5; 42-44; 182-184; | PS00005 | |
| Proteasome subunit alpha type [Q4QC00] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruS | |
| Percent Identity | 54% | |
| Target Region | 1-244 | |
| Template Region | 8-234 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| SER | 35 | Sidechain, Backbone amide |
| LYS | 66 | Sidechain |
| GLY | 80 | Backbone amide |
| GLY | 172 | Sidechain, Backbone amide (SER 172 in Template) |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/3212881/Q4QC00.pdb 2.0 244 = residues | | = | +| Ramachandran plot: 92.0% core 7.5% allow 0.5% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 242) = | +| Chi1-chi2 plots: 3 labelled residues (out of 135) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.5 Bad contacts: = 0 | *| Bond len/angle: 6.4 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.08 Covalent: -0.13 Overall: = 0.00 | | = | | M/c bond lengths: 99.1% within limits 0.9% highlighted = | | M/c bond angles: 94.2% within limits 5.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |