| Adaptor complex AP-1 medium subunit, putative [Q4QBN3] | |
|---|---|
| Systematic Name | LmjF.22.1140 [Leishmania major] |
| Gene Name | LMJF_22_1140 |
| Molecular Weight | 49095 Da |
| Protein Sequence Size | 433 |
| Function | |
| Charge | 1.5 |
| Isoelectric Point | 6.8 pH |
| Description | Adaptor complex AP-1 medium subunit, putative (Mu-adaptin 1, putative). |
| Subcellular Location | AP-1 adaptor complex; clathrin vesicle coat[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QBN3|Q4QBN3_LEIMA Adaptor complex AP-1 medium subunit, putative (Mu-adaptin 1, putative) - Leishmania major ASVLYILDSKGSPLIYRSYRGDVSQDVPSVFQQRVIDEEESRITPVFEEQGHTYTFVREN DVYLLMVSTINACSLQQVAFLRRCVSVFNAYFKTVTQETVRDNFVIIYELLDEMCDFGFP QFTEEKALREHILQSTFLTRILGNKTTLAQSELPAAVTGAAGSTPWRLPRNYKYSNNQVF LDVIEQVDMLASQAGETLSSEIVGTVKMQSRLSGMPTCTVGVNDKILFDRTGRSGSTVEM EDITFHQCVKLNQFESERVISFVPPDGEFTLLSYRLNERIQQPVKVSCIFTRHGTTRVKV QCTLQTKYRASLTANEMEVYIPIPSDADCPQSNSQTGHLQYAPQMNALIWNLGKIAGNRH CSCSAEFHLPSIRSSDMKDLSKMPVKVRFVIPYFAASGFQVRYVKVSEKSNYVATPWVRY VTQSGVYEIRTD |
| DNA Sequence | >LmjF22.1140 |||adaptor complex AP-1 medium subunit, putative|Leishmania major|chr 22|||Manual ATGGCGTCGG TGCTGTACAT CTTGGACTCG AAAGGGAGTC CCCTCATCTA CCGCAGCTACCGCGGCGATG TCTCGCAAGA CGTCCCGAGC GTCTTTCAGC AGCGCGTCAT CGACGAAGAAGAGAGCCGCA TCACCCCCGT CTTCGAGGAG CAGGGCCACA CCTACACCTT CGTGCGCGAGAACGACGTAT ATTTGCTCAT GGTGAGCACT ATCAACGCAT GCTCCCTGCA GCAGGTCGCCTTTCTGCGCC GGTGCGTATC CGTCTTCAAC GCCTATTTCA AGACGGTGAC GCAGGAAACGGTGCGGGACA ACTTCGTCAT CATTTACGAG CTGCTCGATG AGATGTGCGA CTTCGGCTTCCCGCAGTTCA CGGAGGAGAA AGCACTGCGG GAGCACATAC TGCAGAGCAC CTTTCTCACCAGGATCTTGG GCAACAAGAC GACGCTCGCG CAGAGCGAGC TGCCGGCGGC CGTGACGGGAGCCGCCGGGT CGACGCCGTG GCGCTTGCCG CGCAACTACA AGTACTCAAA CAACCAAGTGTTTCTGGACG TGATCGAGCA GGTCGACATG CTCGCGAGCC AAGCCGGCGA GACGCTCTCGAGCGAGATTG TCGGCACTGT CAAGATGCAG AGCCGTCTTT CTGGGATGCC CACCTGCACCGTCGGCGTCA ACGACAAGAT TCTCTTCGAC CGAACCGGCC GCAGCGGCAG CACGGTAGAGATGGAGGACA TTACCTTCCA CCAGTGCGTG AAGCTGAACC AGTTCGAAAG CGAGCGCGTCATTTCCTTTG TGCCACCGGA CGGCGAGTTC ACGCTGCTCT CCTACAGGCT CAACGAGCGCATTCAGCAAC CAGTGAAGGT GAGCTGCATC TTCACGCGCC ACGGCACCAC ACGAGTGAAGGTGCAGTGCA CACTGCAGAC CAAGTACCGC GCGAGCCTCA CGGCGAACGA GATGGAGGTGTACATCCCGA TTCCGTCCGA CGCCGATTGC CCTCAGTCAA ACAGCCAGAC AGGTCACCTGCAGTACGCGC CGCAGATGAA TGCGCTTATC TGGAACCTCG GCAAGATCGC CGGCAACCGGCACTGCTCGT GCAGCGCGGA GTTCCACCTG CCCAGCATCC GCAGTAGCGA CATGAAAGACCTGTCGAAGA TGCCGGTGAA GGTGCGATTT GTCATCCCCT ACTTCGCCGC CTCCGGCTTCCAGGTGCGCT ACGTGAAGGT ATCGGAGAAG TCGAACTACG TGGCAACACC CTGGGTGCGGTACGTCACGC AGAGCGGCGT CTACGAGATT CGAACAGACT GA |
| Adaptor complex AP-1 medium subunit, putative Q4QBN3] | |
|---|---|
| Metabolite Information | |
| Molecular Function | clathrin binding |
| Biochemical Pathway | intracellular protein transport; protein targeting; transport; vesicle targeting |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | adaptor-related protein complex 1, mu 1 subunit [Homo sapiens] | 43 | 1e-105 | 380 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| serS seryl-tRNA synthetase | Mycobacterium tuberculosis H37Rv | 41% | 0.6 | 29.6 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 21-23; | PS00016 | |
| PDOC51072 | Mu homology domain (MHD) profile | 82.222 | 174-432 | PS51072 |
| Acylation | N-myristoylation site | 144-149; 160-165; 215-220; 358-363; | PS00008 | |
| Glycosylation | N-glycosylation site | 145-148; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 100-103; 237-240; 314-317; 326-329; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 19-21; 100-102; 206-208; 232-234; 257-259; 274-276; 296-298; 372-374; 408-410; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 406-413; | PS00007 | |
| Adaptor complex AP-1 medium subunit, putative [Q4QBN3] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1w63V | |
| Percent Identity | 43% | |
| Target Region | 1-434 | |
| Template Region | 2-388 | |
| Domain Information | ||
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| Domains | Start | End |
| Active Site Information | ||
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| Residue | Active Site Number | Functional Part |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
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| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/174951/Q4QBN3.pdb 2.0 433 = residues | | = | *| Ramachandran plot: 85.5% core 12.5% allow 1.5% gener 0.5% = disall | | = | *| All Ramachandrans: 23 labelled residues (out of 431) = | *| Chi1-chi2 plots: 9 labelled residues (out of 249) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 13 | *| Bond len/angle: 11.0 Morris et al class: 1 = 1 3 | +| 1 cis-peptides = | | G-factors Dihedrals: -0.21 Covalent: -0.46 Overall: = -0.29 | | = | | M/c bond lengths: 97.8% within limits 2.2% highlighted = | *| M/c bond angles: 88.5% within limits 11.5% highlighted 3 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |