| Farnesyl pyrophosphate synthase, putative [Q4QBL1] | |
|---|---|
| Systematic Name | LmjF.22.1360 [Leishmania major] |
| Gene Name | FPPS |
| Molecular Weight | 40967 Da |
| Protein Sequence Size | 362 |
| Function | |
| Charge | -5.5 |
| Isoelectric Point | 5.6045 pH |
| Description | Farnesyl pyrophosphate synthase, putative (EC 2.5.1.10). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.5.1.10 |
| Sequence | >tr|Q4QBL1|Q4QBL1_LEIMA Farnesyl pyrophosphate synthase, putative (EC 2.5.1.10) - Leishmania major AHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEA MAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTA QVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLD AKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMV MGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTD PAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQ K |
| DNA Sequence | >LmjF22.1360 |||farnesyl pyrophosphate synthase, putative|Leishmania major|chr 22|||Manual ATGGCGCACA TGGAACGCTT CCAGAAGGTG TACGAGGAGG TTCAGGAGTT CCTACTCGGCGATGCGGAGA AGCGCTTCGA AATGGATGTC CACCGCAAGG GCTACCTGAA GTCTATGATGGACACTACGT GCCTCGGCGG CAAGTACAAC CGAGGTCTCT GCGTCGTGGA CGTGGCGGAGGCGATGGCGA AGGATACGCA GATGGATGCG GCTGCGATGG AGCGCGTTCT GCACGACGCGTGTGTGTGCG GCTGGATGAT CGAGATGCTG CAGGCCCACT TCCTTGTGGA GGACGACATCATGGACCACA GCAAGACTCG CCGCGGCAAG CCGTGCTGGT ACCTGCACCC CGGCGTGACCGCGCAGGTGG CCATCAATGA CGGTCTCATT CTGCTGGCCT GGGCGACGCA GATGGCACTGCACTACTTCG CCGACCGCCC GTTCCTCGCC GAGGTGCTGC GTGTTTTCCA CGACGTCGATCTCACTACCA CGATTGGTCA GCTGTACGAC GTCACGTCGA TGGTGGACTC AGCGAAGCTGGACGCCAAAG TGGCGCACGC CAACACGACG GACTACGTCG AGTACACACC CTTTAACCACCGCCGCATCG TTGTGTACAA GACCGCCTAC TACACCTACT GGCTGCCGCT GGTGATGGGCCTTCTGGTGA GCGGGACACT GGAGAAAGTG GACAAGAAGG CGACGCACAA GGTGGCCATGGTGATGGGCG AGTACTTTCA GGTGCAGGAC GACGTGATGG ACTGCTTCAC CCCGCCCGAGAAGCTTGGCA AAATCGGCAC CGACATTGAA GACGCCAAGT GCTCGTGGCT CGCTGTCACCTTCCTGACGA CCGCCCCGGC CGAGAAGGTC GCGGAGTTCA AGGCCAACTA CGGCTCCACTGATCCGGCCG CGGTCGCCGT TATCAAGCAG CTTTACACCG AGCAGAACCT GCTCGCCCGCTTCGAGGAGT ACGAGAAGGC CGTTGTGGCG GAGGTCGAGC AGCTCATCGC TGCGCTGGAGGCGCAGAATG CCGCCTTCGC GGCTAGCGTG AAGGTGCTTT GGAGCAAGAC TTACAAGCGCCAAAAGTAA |
| Farnesyl pyrophosphate synthase, putative Q4QBL1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | geranyltranstransferase activity |
| Biochemical Pathway | farnesyl diphosphate biosynthesis; isoprenoid biosynthesis |
| Regulatory Pathway | |
| KEGG Pathways | K00787 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | farnesyl diphosphate synthase [Homo sapiens] | 39 | 7e-51 | 198 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YJL167w farnesyl-pyrophosphate synthetase | Saccharomyces cerevisiae | 33% | 2e-53 | 203 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00407 | Polyprenyl synthetases signatures | 242-254; | PS00444 | |
| PDOC00407 | Polyprenyl synthetases signatures | 95-109; | PS00723 | |
| Acylation | N-myristoylation site | 46-51; 220-225; | PS00008 | |
| Glycosylation | N-glycosylation site | 188-191; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 232-235; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 38-41; 66-69; 173-176; 257-260; 267-270; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 106-108; 177-179; 235-237; 349-351; 357-359; | PS00005 | |
| Farnesyl pyrophosphate synthase, putative [Q4QBL1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ogdB | |
| Percent Identity | 60% | |
| Target Region | 1-362 | |
| Template Region | 1-359 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ARG | 107 | Sidechain |
| PHE | 246 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 71-50-1 | ACETATE ION | 59.044 | C2 H3 O2 | [O-]C(=O)C | 2ogd |
| 60-24-2 | BETA-MERCAPTOETHANOL | 78.133 | C2 H6 O S | OCCS | 2ogd |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2ogd |
| (4S)-2-METHYL-2,4-PENTANEDIOL | 118.174 | C6 H14 O2 | OC(C)CC(O)(C)C | 2ogd | |
| 2-(DIMETHYL-LAMBDA~4~-SULFANYL)-1-HYDROXYETHANE- 1,1-DIYL]BIS(PHOSPHONIC ACID) | 268.162 | C4 H14 O7 P2 S | O=P(O)(O)C(O)(P(=O)(O)O)CS(C)C | 2ogd | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2273232/Q4QBL1.pdb 2.0 360 = residues | | = | | Ramachandran plot: 96.7% core 3.3% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 358) = | +| Chi1-chi2 plots: 1 labelled residues (out of 215) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 4.5 Bad contacts: = 2 | +| Bond len/angle: 4.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.27 Covalent: 0.00 Overall: = 0.17 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 96.3% within limits 3.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |