| Peroxidoxin [Q4QBH2] | |
|---|---|
| Systematic Name | LmjF.23.0040 [Leishmania major] |
| Gene Name | LMJF_23_0040 |
| Molecular Weight | 25342 Da |
| Protein Sequence Size | 226 |
| Function | |
| Charge | 1 |
| Isoelectric Point | 6.9342 pH |
| Description | Peroxidoxin (Tryparedoxin peroxidase) (EC 1.11.1.-). |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | 1.11.1.- |
| Sequence | >tr|Q4QBH2|Q4QBH2_LEIMA Peroxidoxin (Tryparedoxin peroxidase) (EC 1.11.1.-) - Leishmania major LRRLSTSSFLKRAQFRGFAATSPLLNLDYQMYRTATVREAAPQFSGQAVVNGAIKDINMN DYKGKYIVLFFYPMDFTFVCPTEIIAFSDRHADFEKLNTQVVAVSCDSVYSHLAWVNTPR KKGGLGEMHIPVLADKSMEIARDYGVLIEESGIALRGLFIIDKKGILRHSTINDLPVGRN VDEALRVLEAFQYADENGDAIPCGWKPGQPTLDTTKAAEFFEKNM |
| DNA Sequence | >LmjF23.0040 |||peroxidoxin|Leishmania major|chr 23|||Manual ATGCTCCGCC GTCTTTCCAC TAGCTCCTTC CTGAAGCGCG CGCAGTTTCG CGGGTTCGCGGCTACGTCGC CGCTTTTGAA CCTGGACTAT CAGATGTACC GTACAGCGAC CGTCCGTGAAGCTGCGCCAC AGTTTTCCGG CCAGGCTGTC GTGAATGGTG CAATTAAGGA TATAAACATGAACGACTACA AGGGCAAGTA CATTGTGCTG TTTTTCTATC CGATGGACTT CACCTTCGTTTGCCCGACCG AGATCATTGC GTTTTCGGAT CGCCACGCCG ACTTCGAGAA GCTGAACACGCAGGTTGTTG CGGTGTCGTG CGATTCGGTG TACTCTCACC TGGCGTGGGT GAACACGCCACGCAAAAAGG GTGGCCTCGG TGAAATGCAC ATCCCGGTAC TGGCGGACAA ATCGATGGAAATCGCTCGTG ACTACGGTGT GCTGATCGAA GAATCCGGTA TCGCTCTTCG AGGACTCTTTATCATCGACA AGAAGGGCAT CCTGCGCCAC TCGACGATCA ATGACCTTCC TGTGGGTCGCAACGTGGACG AGGCACTGCG CGTGTTGGAG GCTTTCCAGT ACGCAGACGA GAACGGAGACGCGATCCCGT GCGGATGGAA GCCTGGACAG CCCACGCTGG ACACCACAAA GGCAGCCGAGTTTTTCGAGA AGAACATGTG A |
| Peroxidoxin Q4QBH2] | |
|---|---|
| Metabolite Information | |
| Molecular Function | trypanothione-disulfide reductase activity |
| Biochemical Pathway | electron transport |
| Regulatory Pathway | |
| KEGG Pathways | K03386 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | peroxiredoxin 2 isoform a [Homo sapiens] | 59 | 5e-66 | 247 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| MG200 DnaJ domain protein | Mycoplasma genitalium | 44% | 3.7 | 25.8 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 3-6; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 37-40; 172-175; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 37-39; 89-91; 119-121; 215-217; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 187-194; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 187-201; | PS00003 | |
| Peroxidoxin [Q4QBH2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1qmvJ | |
| Percent Identity | 59% | |
| Target Region | 35-228 | |
| Template Region | 195 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/259100/Q4QBH2.pdb 2.0 192 = residues | | = | | Ramachandran plot: 95.2% core 4.8% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 190) = | | Chi1-chi2 plots: 0 labelled residues (out of 115) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.4 Bad contacts: = 1 | *| Bond len/angle: 6.0 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.14 Covalent: -0.13 Overall: = 0.04 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 94.1% within limits 5.9% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |